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Protein
Submitted name:

Trifunctional enzyme subunit alpha, mitochondrial

Gene

HADHA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Trifunctional enzyme subunit alpha, mitochondrialImported
Gene namesi
Name:HADHAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000084754.10
HGNCiHGNC:4801 HADHA

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000084754

PTM / Processingi

Proteomic databases

MaxQBiH0YFD6
PeptideAtlasiH0YFD6
PRIDEiH0YFD6

Expressioni

Gene expression databases

BgeeiENSG00000084754
ExpressionAtlasiH0YFD6 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH0YFD6
SMRiH0YFD6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini364 – 5413HCDH_NInterPro annotationAdd BLAST178
Domaini544 – 6393HCDHInterPro annotationAdd BLAST96

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili113 – 133Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the enoyl-CoA hydratase/isomerase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

GeneTreeiENSGT00880000137923

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR006180 3-OHacyl-CoA_DH_CS
IPR006176 3-OHacyl-CoA_DH_NAD-bd
IPR006108 3HC_DH_C
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR029045 ClpP/crotonase-like_dom_sf
IPR018376 Enoyl-CoA_hyd/isom_CS
IPR001753 Enoyl-CoA_hydra/iso
IPR012803 Fa_ox_alpha_mit
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF00725 3HCDH, 1 hit
PF02737 3HCDH_N, 1 hit
PF00378 ECH_1, 1 hit
SUPFAMiSSF48179 SSF48179, 2 hits
SSF51735 SSF51735, 1 hit
SSF52096 SSF52096, 1 hit
TIGRFAMsiTIGR02441 fa_ox_alpha_mit, 1 hit
PROSITEiView protein in PROSITE
PS00067 3HCDH, 1 hit
PS00166 ENOYL_COA_HYDRATASE, 1 hit

Sequencei

Sequence statusi: Complete.

H0YFD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVACRAIGIL SRFSAFRILR SRGYICRNFT GSSALLTRTH INYGVKGDVA
60 70 80 90 100
VVRINSPNSK VNTLSKELHS EFSEVMNEIW ASDQIRSAVL ISSKPGCFIA
110 120 130 140 150
GADINMLAAC KTLQEVTQLS QEAQRIVEKL EKSTKPIVAA INGSCLGGGL
160 170 180 190 200
EVAISCQYRI ATKDRKTVLG TPEVLLGALP GAGGTQRLPK MVGVPAALDM
210 220 230 240 250
MLTGRSIRAD RAKKMGLVDQ LVEPLGPGLK PPEERTIEYL EEVAITFAKG
260 270 280 290 300
LADKKISPKR DKGLVEKLTA YAMTIPFVRQ QVYKKVEEKV RKQTKGLYPA
310 320 330 340 350
PLKIIDVVKT GIEQGSDAGY LCESQKFGEL VMTKESKALM GLYHGQVLCK
360 370 380 390 400
KNKFGAPQKD VKHLAILGAG LMGAGIAQVS VDKGLKTILK DATLTALDRG
410 420 430 440 450
QQQVFKGLND KVKKKALTSF ERDSIFSNLT GQLDYQGFEK ADMVIEAVFE
460 470 480 490 500
DLSLKHRVLK EVEAVIPDHC IFASNTSALP ISEIAAVSKR PEKVIGMHYF
510 520 530 540 550
SPVDKMQLLE IITTEKTSKD TSASAVAVGL KQGKVIIVVK DGPGFYTTRC
560 570 580 590 600
LAPMMSEVIR ILQEGVDPKK LDSLTTSFGF PVGAATLVDE VGVDVAKHVA
610 620 630 640 650
EDLGKVFGER FGGGNPELLT QMVSKGFLGR KSGKGFYIYQ EGVKRKDLNS
660 670 680 690 700
DMDSILASLK LPPKSEVSSD EDIQFRLVTR FVNEAVMCLQ EGILATPAEG
710 720 730 740 750
DIGAVFGLGF PPCLGGWSRR LGRKLTLAWS PCCVSFNEVL FLYSGPFRFV
760 770 780 790
DLYGAQKIVD RLKKYEAAYG KQFTPCQLLA DHANSPNKKF YQ
Length:792
Mass (Da):86,372
Last modified:June 20, 2018 - v2
Checksum:iAB90E6D953A42E16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010896 Genomic DNA No translation available.
AC011742 Genomic DNA No translation available.
KF510807 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000492433; ENSP00000438039; ENSG00000084754
UCSCiuc061hgx.1 human

Similar proteinsi

Entry informationi

Entry nameiH0YFD6_HUMAN
AccessioniPrimary (citable) accession number: H0YFD6
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: June 20, 2018
Last modified: July 18, 2018
This is version 41 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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