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Protein
Submitted name:

Seizure protein 6 homolog

Gene

SEZ6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Seizure protein 6 homologImported
Gene namesi
Name:SEZ6Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000063015.19
HGNCiHGNC:15955 SEZ6

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei852 – 874HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000063015

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi342 ↔ 369PROSITE-ProRule annotation
Disulfide bondi664 ↔ 691PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PeptideAtlasiH0YF95
PRIDEiH0YF95

Expressioni

Gene expression databases

BgeeiENSG00000063015 Expressed in 107 organ(s), highest expression level in cerebellar vermis
ExpressionAtlasiH0YF95 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH0YF95
SMRiH0YF95
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini281 – 340SushiInterPro annotationAdd BLAST60
Domaini342 – 453CUBInterPro annotationAdd BLAST112
Domaini456 – 517SushiInterPro annotationAdd BLAST62
Domaini519 – 630CUBInterPro annotationAdd BLAST112
Domaini634 – 693SushiInterPro annotationAdd BLAST60
Domaini695 – 758SushiInterPro annotationAdd BLAST64
Domaini762 – 823SushiInterPro annotationAdd BLAST62

Keywords - Domaini

SushiPROSITE-ProRule annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IS3V Eukaryota
ENOG410YA6K LUCA
GeneTreeiENSGT00760000118803

Family and domain databases

CDDicd00033 CCP, 5 hits
cd00041 CUB, 2 hits
Gene3Di2.60.120.290, 2 hits
InterProiView protein in InterPro
IPR000859 CUB_dom
IPR035914 Sperma_CUB_dom_sf
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00431 CUB, 2 hits
PF00084 Sushi, 5 hits
SMARTiView protein in SMART
SM00032 CCP, 5 hits
SM00042 CUB, 2 hits
SUPFAMiSSF49854 SSF49854, 3 hits
SSF57535 SSF57535, 5 hits
PROSITEiView protein in PROSITE
PS01180 CUB, 2 hits
PS50923 SUSHI, 5 hits

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

H0YF95-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
EFLQEGLEKG DEELRPALPF QPDPPAPFTP SPLPRLANQD SRPVFTSPTP
60 70 80 90 100
AMAAVPTQPQ SKEGPWSPES ESPMLRITAP LPPGPSMAVP TLGPGEIAST
110 120 130 140 150
TPPSRAWTPT QEGPGDMGRP WVAEVVSQGA GIGIQGTITS STASGDDEET
160 170 180 190 200
TTTTTIITTT ITTVQTPGPC SWNFSGPEGS LDSPTDLSSP TDVGLDCFFY
210 220 230 240 250
ISVYPGYGVE IKVQNISLRE GETVTVEGLG GPDPLPLANQ SFLLRGQVIR
260 270 280 290 300
SPTHQAALRF QSLPPPAGPG TFHFHYQAYL LSCHFPRRPA YGDVTVTSLH
310 320 330 340 350
PGGSARFHCA TGYQLKGARH LTCLNATQPF WDSKEPVCIA ACGGVIRNAT
360 370 380 390 400
TGRIVSPGFP GNYSNNLTCH WLLEAPEGQR LHLHFEKVSL AEDDDRLIIR
410 420 430 440 450
NGDNVEAPPV YDSYEVEYLP IEGLLSSGKH FFVELSTDSS GAAAGMALRY
460 470 480 490 500
EAFQQGHCYE PFVKYGNFSS STPTYPVGTT VEFSCDPGYT LEQGSIIIEC
510 520 530 540 550
VDPHDPQWNE TEPACRAVCS GEITDSAGVV LSPNWPEPYG RGQDCIWGVH
560 570 580 590 600
VEEDKRIMLD IRVLRIGPGD VLTFYDGDDL TARVLGQYSG PRSHFKLFTS
610 620 630 640 650
MADVTIQFQS DPGTSVLGYQ QGFVIHFFEV PRNDTCPELP EIPNGWKSPS
660 670 680 690 700
QPELVHGTVV TYQCYPGYQV VGSSVLMCQW DLTWSEDLPS CQRVTSCHDP
710 720 730 740 750
GDVEHSRRLI SSPKFPVGAT VQYICDQGFV LMGSSILTCH DRQAGSPKWS
760 770 780 790 800
DRAPKCLLEQ LKPCHGLSAP ENGARSPEKQ LHPAGATIHF SCAPGYVLKG
810 820 830 840 850
QASIKCVPGH PSHWSDPPPI CRAASLDGFY NSRSLDVAKA PAASSTLDAA
860 870 880 890 900
HIAAAIFLPL VAMVLLVGGV YFYFSRLQGK SSLQLPRPRP RPYNRITIES
910
AFDNPTYETG ETREYEVSI
Length:919
Mass (Da):99,684
Last modified:January 9, 2013 - v2
Checksum:i1AB35EE44E8E5B9D
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q53EL9SEZ6_HUMAN
Seizure protein 6 homolog
SEZ6
994Annotation score:
C9JFF1C9JFF1_HUMAN
Seizure protein 6 homolog
SEZ6
994Annotation score:
A0A0A0MSU7A0A0A0MSU7_HUMAN
Seizure protein 6 homolog
SEZ6
980Annotation score:
H0YFX0H0YFX0_HUMAN
Seizure protein 6 homolog
SEZ6
454Annotation score:
H0YGK0H0YGK0_HUMAN
Seizure protein 6 homolog
SEZ6
131Annotation score:
H0YFT6H0YFT6_HUMAN
Seizure protein 6 homolog
SEZ6
101Annotation score:
K7ELJ4K7ELJ4_HUMAN
Seizure protein 6 homolog
SEZ6
56Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC024267 Genomic DNA No translation available.
AC024619 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000540632; ENSP00000437650; ENSG00000063015
UCSCiuc060dhf.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC024267 Genomic DNA No translation available.
AC024619 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH0YF95
SMRiH0YF95
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiH0YF95
PRIDEiH0YF95

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000540632; ENSP00000437650; ENSG00000063015
UCSCiuc060dhf.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000063015.19
HGNCiHGNC:15955 SEZ6
OpenTargetsiENSG00000063015
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IS3V Eukaryota
ENOG410YA6K LUCA
GeneTreeiENSGT00760000118803

Miscellaneous databases

ChiTaRSiSEZ6 human

Gene expression databases

BgeeiENSG00000063015 Expressed in 107 organ(s), highest expression level in cerebellar vermis
ExpressionAtlasiH0YF95 baseline and differential

Family and domain databases

CDDicd00033 CCP, 5 hits
cd00041 CUB, 2 hits
Gene3Di2.60.120.290, 2 hits
InterProiView protein in InterPro
IPR000859 CUB_dom
IPR035914 Sperma_CUB_dom_sf
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00431 CUB, 2 hits
PF00084 Sushi, 5 hits
SMARTiView protein in SMART
SM00032 CCP, 5 hits
SM00042 CUB, 2 hits
SUPFAMiSSF49854 SSF49854, 3 hits
SSF57535 SSF57535, 5 hits
PROSITEiView protein in PROSITE
PS01180 CUB, 2 hits
PS50923 SUSHI, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiH0YF95_HUMAN
AccessioniPrimary (citable) accession number: H0YF95
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: January 9, 2013
Last modified: September 12, 2018
This is version 48 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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