UniProtKB - H0YED9 (H0YED9_HUMAN)
Protein
Submitted name:
Wilms tumor protein
Gene
WT1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- RNA binding Source: UniProtKB-KW
GO - Biological processi
- regulation of transcription, DNA-templated Source: InterPro
Keywordsi
Molecular function | DNA-bindingARBA annotation, RNA-bindingARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Wilms tumor proteinImported |
Gene namesi | Name:WT1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12796, WT1 |
VEuPathDBi | HostDB:ENSG00000184937.12 |
Subcellular locationi
Nucleus
- Nucleus speckle ARBA annotation
Other locations
- Cytoplasm ARBA annotation
Cytosol
- cytosol Source: HPA
Nucleus
- nuclear speck Source: UniProtKB-SubCell
- nucleoplasm Source: HPA
Keywords - Cellular componenti
CytoplasmARBA annotation, NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000184937, Expressed in germinal epithelium of ovary and 130 other tissues |
ExpressionAtlasi | H0YED9, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 82 – 111 | C2H2-typeInterPro annotationAdd BLAST | 30 | |
Domaini | 112 – 139 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 143 – 172 | C2H2-typeInterPro annotationAdd BLAST | 30 |
Sequence similaritiesi
Belongs to the EGR C2H2-type zinc-finger protein family.ARBA annotation
Keywords - Domaini
RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationPhylogenomic databases
GeneTreei | ENSGT00940000156734 |
HOGENOMi | CLU_002678_42_27_1 |
Family and domain databases
InterProi | View protein in InterPro IPR017987, Wilms_tumour IPR000976, Wilms_tumour_N IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR23235:SF49, PTHR23235:SF49, 2 hits |
Pfami | View protein in Pfam PF02165, WT1, 1 hit PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
H0YED9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
XLGATLKGVA AGSSSSVKWT EGQSNHSTGY ESDNHTTPIL CGAQYRIHTH
60 70 80 90 100
GVFRGIQDVR RVPGVAPTLV RSASETSEKR PFMCAYPGCN KRYFKLSHLQ
110 120 130 140 150
MHSRKHTGVK PFQCKTCQRK FSRSDHLKTH TRTHTGKTSE KPFSCRWPSC
160 170
QKKFARSDEL VRHHNMHQRN MTKLQLAL
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP19544 | WT1_HUMAN | Wilms tumor protein | WT1 | 449 | Annotation score: | ||
H0Y7K5 | H0Y7K5_HUMAN | Wilms tumor protein | WT1 | 519 | Annotation score: | ||
J3KNN9 | J3KNN9_HUMAN | Wilms tumor protein | WT1 | 502 | Annotation score: | ||
A0A0A0MT54 | A0A0A0MT54_HUMAN | Wilms tumor protein | WT1 | 522 | Annotation score: | ||
A0A1W2PR07 | A0A1W2PR07_HUMAN | Wilms tumor protein | WT1 | 297 | Annotation score: | ||
A0A1W2PQQ0 | A0A1W2PQQ0_HUMAN | Wilms tumor protein | WT1 | 505 | Annotation score: | ||
H0Y3F0 | H0Y3F0_HUMAN | Wilms tumor protein | WT1 | 322 | Annotation score: | ||
A0A494C0I9 | A0A494C0I9_HUMAN | Wilms tumor protein | WT1 | 43 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL049692 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000527882; ENSP00000435624; ENSG00000184937 |
UCSCi | uc058adh.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL049692 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | H0YED9 |
PRIDEi | H0YED9 |
ProteomicsDBi | 37698 |
Protocols and materials databases
Antibodypediai | 3523, 1083 antibodies |
Genome annotation databases
Ensembli | ENST00000527882; ENSP00000435624; ENSG00000184937 |
UCSCi | uc058adh.1, human |
Organism-specific databases
HGNCi | HGNC:12796, WT1 |
OpenTargetsi | ENSG00000184937 |
VEuPathDBi | HostDB:ENSG00000184937.12 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000156734 |
HOGENOMi | CLU_002678_42_27_1 |
Miscellaneous databases
ChiTaRSi | WT1, human |
Gene expression databases
Bgeei | ENSG00000184937, Expressed in germinal epithelium of ovary and 130 other tissues |
ExpressionAtlasi | H0YED9, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR017987, Wilms_tumour IPR000976, Wilms_tumour_N IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR23235:SF49, PTHR23235:SF49, 2 hits |
Pfami | View protein in Pfam PF02165, WT1, 1 hit PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H0YED9_HUMAN | |
Accessioni | H0YED9Primary (citable) accession number: H0YED9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 22, 2012 |
Last sequence update: | February 22, 2012 | |
Last modified: | February 10, 2021 | |
This is version 56 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |