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Protein
Submitted name:

Non-receptor tyrosine-protein kinase TYK2

Gene

TYK2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Non-receptor tyrosine-protein kinase TYK2Imported
Gene namesi
Name:TYK2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105397.13
HGNCiHGNC:12440 TYK2

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000105397

PTM / Processingi

Proteomic databases

PeptideAtlasiH0YE41
PRIDEiH0YE41

Expressioni

Gene expression databases

BgeeiENSG00000105397 Expressed in 226 organ(s), highest expression level in spleen
ExpressionAtlasiH0YE41 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH0YE41
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG0197 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00900000140909

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.iShow all

H0YE41-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XIRQHSALTR LRLRNVFRRF LRDFQPGRLS QQMVMVKYLA TLERLAPRFG
60 70 80 90 100
TERVPVCHLR LLAQAEGEPC YIRDSGVAPT DPGPESAAGP PTHEVLVTGT
110 120 130 140 150
GGIQWWPVEE EVNKEEELSL PSRAAALSFV SLVDGYFRLT ADSSHYLCHE
160 170 180 190
VAPPRLVMSI RDGIHGPLLE PFVQAKLRPE DGLYLIHWST SHPY
Length:194
Mass (Da):21,872
Last modified:October 5, 2016 - v8
Checksum:iF60BF37EB624808C
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P29597TYK2_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
1,187Annotation score:
E9PPF2E9PPF2_HUMAN
Tyrosine-protein kinase
TYK2
921Annotation score:
E9PM19E9PM19_HUMAN
Tyrosine-protein kinase
TYK2
1,002Annotation score:
K7EJR6K7EJR6_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
142Annotation score:
K7EM33K7EM33_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
135Annotation score:
E9PQL2E9PQL2_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
118Annotation score:
H0YE24H0YE24_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
64Annotation score:
H0YCT7H0YCT7_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
82Annotation score:
E9PQE9E9PQE9_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
134Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei194Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011557 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000525220; ENSP00000434931; ENSG00000105397
UCSCiuc060thw.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011557 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH0YE41
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiH0YE41
PRIDEiH0YE41

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000525220; ENSP00000434931; ENSG00000105397
UCSCiuc060thw.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000105397.13
HGNCiHGNC:12440 TYK2
OpenTargetsiENSG00000105397
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0197 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00900000140909

Miscellaneous databases

ChiTaRSiTYK2 human

Gene expression databases

BgeeiENSG00000105397 Expressed in 226 organ(s), highest expression level in spleen
ExpressionAtlasiH0YE41 baseline and differential

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiH0YE41_HUMAN
AccessioniPrimary (citable) accession number: H0YE41
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: October 5, 2016
Last modified: September 12, 2018
This is version 43 of the entry and version 8 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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