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Protein
Submitted name:

Cytoplasmic dynein 2 heavy chain 1

Gene

DYNC2H1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Cytoplasmic dynein 2 heavy chain 1Imported
Gene namesi
Name:DYNC2H1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000187240.13
HGNCiHGNC:2962 DYNC2H1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000187240

PTM / Processingi

Proteomic databases

MaxQBiH0YDE0
PeptideAtlasiH0YDE0
PRIDEiH0YDE0

Expressioni

Gene expression databases

BgeeiENSG00000187240 Expressed in 178 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiH0YDE0 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH0YDE0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 351Dynein_heavyInterPro annotationAdd BLAST343

Phylogenomic databases

eggNOGiKOG3595 Eukaryota
COG5245 LUCA
GeneTreeiENSGT00910000144015

Family and domain databases

InterProiView protein in InterPro
IPR026983 DHC_fam
IPR026815 DYNC2H1
IPR004273 Dynein_heavy_dom
PANTHERiPTHR10676 PTHR10676, 1 hit
PTHR10676:SF352 PTHR10676:SF352, 1 hit
PfamiView protein in Pfam
PF03028 Dynein_heavy, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

H0YDE0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
QKIRDQLPSW IDQERSWAVA TLKIALPSLY QTLCFEDAAL WRTYYNNSMC
60 70 80 90 100
EQEFPSILAK KVSLFQQILV VQALRPDRLQ SAMALFACKT LGLKEVSPLP
110 120 130 140 150
LNLKRLYKET LEIEPILIII SPGADPSQEL QELANAERSG ECYHQVAMGQ
160 170 180 190 200
GQADLAIQML KECARNGDWL CLKNLHLVVS WLPVLEKELN TLQPKDTFRL
210 220 230 240 250
WLTAEVHPNF TPILLQSSLK ITYESPPGLK KNLMRTYESW TPEQISKKDN
260 270 280 290 300
THRAHALFSL AWFHAACQER RNYIPQGWTK FYEFSLSDLR AGYNIIDRLF
310 320 330 340 350
DGAKDVQWEF VHGLLENAIY GGRIDNYFDL RVLQSYLKQF FNSSVIDVFN
360 370
QRNKKSIFPY SVSLPQSCSI LVGLSCCH
Length:378
Mass (Da):43,528
Last modified:February 22, 2012 - v1
Checksum:i381DACD10F352DAA
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8NCM8DYHC2_HUMAN
Cytoplasmic dynein 2 heavy chain 1
DYNC2H1 DHC1B, DHC2, DNCH2, DYH1B, KIAA1997
4,307Annotation score:
H0YEX1H0YEX1_HUMAN
Cytoplasmic dynein 2 heavy chain 1
DYNC2H1
224Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000817 Genomic DNA No translation available.
AP001486 Genomic DNA No translation available.
AP002961 Genomic DNA No translation available.
AP003382 Genomic DNA No translation available.
KF455481 Genomic DNA No translation available.
KF455487 Genomic DNA No translation available.
KF511110 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000528670; ENSP00000433451; ENSG00000187240
UCSCiuc058gww.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000817 Genomic DNA No translation available.
AP001486 Genomic DNA No translation available.
AP002961 Genomic DNA No translation available.
AP003382 Genomic DNA No translation available.
KF455481 Genomic DNA No translation available.
KF455487 Genomic DNA No translation available.
KF511110 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH0YDE0
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiH0YDE0
PeptideAtlasiH0YDE0
PRIDEiH0YDE0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000528670; ENSP00000433451; ENSG00000187240
UCSCiuc058gww.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000187240.13
HGNCiHGNC:2962 DYNC2H1
OpenTargetsiENSG00000187240
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3595 Eukaryota
COG5245 LUCA
GeneTreeiENSGT00910000144015

Miscellaneous databases

ChiTaRSiDYNC2H1 human

Gene expression databases

BgeeiENSG00000187240 Expressed in 178 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiH0YDE0 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR026983 DHC_fam
IPR026815 DYNC2H1
IPR004273 Dynein_heavy_dom
PANTHERiPTHR10676 PTHR10676, 1 hit
PTHR10676:SF352 PTHR10676:SF352, 1 hit
PfamiView protein in Pfam
PF03028 Dynein_heavy, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH0YDE0_HUMAN
AccessioniPrimary (citable) accession number: H0YDE0
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: September 12, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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