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UniProtKB - H0YDD4 (H0YDD4_HUMAN)
Protein
Acetyltransferase component of pyruvate dehydrogenase complex
Gene
DLAT
Organism
Homo sapiens (Human)
Status
Functioni
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
UniRule annotationCatalytic activityi
- (R)-N6-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA = (R)-N6-(S8-acetyldihydrolipoyl)-L-lysyl-[protein] + CoAUniRule annotationARBA annotationEC:2.3.1.12UniRule annotationARBA annotation
Cofactori
(R)-lipoateUniRule annotationNote: Binds 1 lipoyl cofactor covalently.UniRule annotation
GO - Molecular functioni
- dihydrolipoyllysine-residue acetyltransferase activity Source: UniProtKB-UniRule
GO - Biological processi
- pyruvate metabolic process Source: InterPro
Keywordsi
Molecular function | AcyltransferaseUniRule annotation, Transferase |
Names & Taxonomyi
Protein namesi | Recommended name: Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation) |
Gene namesi | Name:DLATImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2896, DLAT |
VEuPathDBi | HostDB:ENSG00000150768 |
Subcellular locationi
Mitochondrion
- Mitochondrion matrix UniRule annotationARBA annotation
Mitochondrion
- mitochondrial matrix Source: UniProtKB-SubCell
- mitochondrion Source: HPA
Other locations
- intracellular membrane-bounded organelle Source: HPA
- pyruvate dehydrogenase complex Source: InterPro
PTM / Processingi
Proteomic databases
MaxQBi | H0YDD4 |
PeptideAtlasi | H0YDD4 |
PRIDEi | H0YDD4 |
ProteomicsDBi | 37357 |
PTM databases
SwissPalmi | H0YDD4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000150768, Expressed in heart and 247 other tissues |
ExpressionAtlasi | H0YDD4, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 91 – 167 | Lipoyl-bindingInterPro annotationAdd BLAST | 77 | |
Domaini | 229 – 266 | Peripheral subunit-binding (PSBD)InterPro annotationAdd BLAST | 38 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 29 – 49 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 185 – 221 | DisorderedSequence analysisAdd BLAST | 37 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 187 – 220 | Pro residuesSequence analysisAdd BLAST | 34 |
Sequence similaritiesi
Keywords - Domaini
LipoylUniRule annotationARBA annotation, Transit peptideARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000154943 |
HOGENOMi | CLU_016733_10_2_1 |
Family and domain databases
Gene3Di | 3.30.559.10, 1 hit 4.10.320.10, 1 hit |
InterProi | View protein in InterPro IPR003016, 2-oxoA_DH_lipoyl-BS IPR001078, 2-oxoacid_DH_actylTfrase IPR000089, Biotin_lipoyl IPR023213, CAT-like_dom_sf IPR045257, E2/Pdx1 IPR036625, E3-bd_dom_sf IPR006257, LAT1 IPR004167, PSBD IPR011053, Single_hybrid_motif |
PANTHERi | PTHR23151, PTHR23151, 1 hit |
Pfami | View protein in Pfam PF00198, 2-oxoacid_dh, 1 hit PF00364, Biotin_lipoyl, 1 hit PF02817, E3_binding, 1 hit |
SUPFAMi | SSF47005, SSF47005, 1 hit SSF51230, SSF51230, 1 hit |
TIGRFAMsi | TIGR01349, PDHac_trf_mito, 1 hit |
PROSITEi | View protein in PROSITE PS50968, BIOTINYL_LIPOYL, 1 hit PS00189, LIPOYL, 1 hit PS51826, PSBD, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 13 potential isoforms that are computationally mapped.Show allAlign All
H0YDD4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWRVCARRAQ NVAPWAGLEA RWTALQEVPG TPRVTSRSGP APARRNSVTT
60 70 80 90 100
GYGGVRALCG WTPSSGATPR NRLLLQLLGS PGRRYYSLPP HQKVPLPSLS
110 120 130 140 150
PTMQAGTIAR WEKKEGDKIN EGDLLAEIET DKATIGFEVQ EEGYLAKILV
160 170 180 190 200
PEGTRDVPLG TPLCIIVEKE ADISAFADYR PTEVTDLKPQ VPPPTPPPVA
210 220 230 240 250
AVPPTPQPLA PTPSAPCPAT PAGPKGRVFV SPLAKKLAVE KGIDLTQVKG
260 270 280 290 300
TGPDGRITKK DIDSFVPSKV APAPAAVVPP TGPGMAPVPT GVFTDIPISN
310 320 330 340 350
IRRVIAQRLM QSKQTIPHYY LSIDVNMGEV LLVRKELNKI LEGRSKISVN
360 370 380 390 400
DFIIKASALA CLKVPEANSS WMDTVIRQNH VVDVSVAVST PAGLITPIVF
410 420 430 440 450
NAHIKGVETI ANDVVSLATK AREGKLQPHE FQGGTFTISN LGMFGIKNFS
460 470 480 490 500
AIINPPQACI LAIGASEDKL VPADNEKGFD VASMMSVTLS CDHRVVDGAV
510 520
GAQWLAEFRK YLEKPITMLL
Computationally mapped potential isoform sequencesi
There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP10515 | ODP2_HUMAN | Dihydrolipoyllysine-residue acetylt... | DLAT DLTA | 647 | Annotation score: | ||
E9PEJ4 | E9PEJ4_HUMAN | Acetyltransferase component of pyru... | DLAT | 542 | Annotation score: | ||
A0A7P0Z4G4 | A0A7P0Z4G4_HUMAN | Acetyltransferase component of pyru... | DLAT | 562 | Annotation score: | ||
A0A7P0T997 | A0A7P0T997_HUMAN | Acetyltransferase component of pyru... | DLAT | 636 | Annotation score: | ||
A0A7P0TA47 | A0A7P0TA47_HUMAN | Acetyltransferase component of pyru... | DLAT | 446 | Annotation score: | ||
A0A7P0TAX2 | A0A7P0TAX2_HUMAN | Acetyltransferase component of pyru... | DLAT | 640 | Annotation score: | ||
A0A7P0TBE2 | A0A7P0TBE2_HUMAN | Acetyltransferase component of pyru... | DLAT | 645 | Annotation score: | ||
A0A7P0TBK2 | A0A7P0TBK2_HUMAN | Acetyltransferase component of pyru... | DLAT | 554 | Annotation score: | ||
A0A7P0TAG1 | A0A7P0TAG1_HUMAN | Dihydrolipoamide acetyltransferase ... | DLAT | 611 | Annotation score: | ||
A0A7P0T9N8 | A0A7P0T9N8_HUMAN | Dihydrolipoyllysine-residue acetylt... | DLAT | 243 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP000907 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000531306; ENSP00000433432; ENSG00000150768 |
UCSCi | uc058hhb.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP000907 Genomic DNA No translation available. |
3D structure databases
SMRi | H0YDD4 |
ModBasei | Search... |
PTM databases
SwissPalmi | H0YDD4 |
Proteomic databases
MaxQBi | H0YDD4 |
PeptideAtlasi | H0YDD4 |
PRIDEi | H0YDD4 |
ProteomicsDBi | 37357 |
Protocols and materials databases
Antibodypediai | 18282, 327 antibodies from 30 providers |
Genome annotation databases
Ensembli | ENST00000531306; ENSP00000433432; ENSG00000150768 |
UCSCi | uc058hhb.1, human |
Organism-specific databases
HGNCi | HGNC:2896, DLAT |
OpenTargetsi | ENSG00000150768 |
VEuPathDBi | HostDB:ENSG00000150768 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000154943 |
HOGENOMi | CLU_016733_10_2_1 |
Miscellaneous databases
ChiTaRSi | DLAT, human |
Gene expression databases
Bgeei | ENSG00000150768, Expressed in heart and 247 other tissues |
ExpressionAtlasi | H0YDD4, baseline and differential |
Family and domain databases
Gene3Di | 3.30.559.10, 1 hit 4.10.320.10, 1 hit |
InterProi | View protein in InterPro IPR003016, 2-oxoA_DH_lipoyl-BS IPR001078, 2-oxoacid_DH_actylTfrase IPR000089, Biotin_lipoyl IPR023213, CAT-like_dom_sf IPR045257, E2/Pdx1 IPR036625, E3-bd_dom_sf IPR006257, LAT1 IPR004167, PSBD IPR011053, Single_hybrid_motif |
PANTHERi | PTHR23151, PTHR23151, 1 hit |
Pfami | View protein in Pfam PF00198, 2-oxoacid_dh, 1 hit PF00364, Biotin_lipoyl, 1 hit PF02817, E3_binding, 1 hit |
SUPFAMi | SSF47005, SSF47005, 1 hit SSF51230, SSF51230, 1 hit |
TIGRFAMsi | TIGR01349, PDHac_trf_mito, 1 hit |
PROSITEi | View protein in PROSITE PS50968, BIOTINYL_LIPOYL, 1 hit PS00189, LIPOYL, 1 hit PS51826, PSBD, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | H0YDD4_HUMAN | |
Accessioni | H0YDD4Primary (citable) accession number: H0YDD4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 22, 2012 |
Last sequence update: | June 2, 2021 | |
Last modified: | January 19, 2022 | |
This is version 69 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |