UniProtKB - H0YDD3 (H0YDD3_HUMAN)
Protein
Alpha-1,3-glucosyltransferase
Gene
ALG8
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
Catalytic activityi
- α-D-Glc-(1→3)-α-D-Man-(1→2)-α-D-Man-(1→2)-α-D-Man-(1→3)-[α-D-Man-(1→2)-α-D-Man-(1→3)-[α-D-Man-(1→2)-α-D-Man-(1→6)]-α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-α-D-GlcNAc-diphosphodolichol + dolichyl β-D-glucosyl phosphate = α-D-Glc-(1→3)-α-D-Glc-(1→3)-α-D-Man-(1→2)-α-D-Man-(1→2)-α-D-Man-(1→3)-[α-D-Man-(1→2)-α-D-Man-(1→3)-[α-D-Man-(1→2)-α-D-Man-(1→6)]-α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-α-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H+ARBA annotationEC:2.4.1.265ARBA annotation
: protein glycosylation Pathwayi
This protein is involved in the pathway protein glycosylation, which is part of Protein modification.UniRule annotationARBA annotationView all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.
GO - Molecular functioni
- dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity Source: UniProtKB-EC
GO - Biological processi
- oligosaccharide-lipid intermediate biosynthetic process Source: InterPro
- protein glycosylation Source: UniProtKB-UniPathway
Keywordsi
Molecular function | GlycosyltransferaseUniRule annotation, Transferase |
Enzyme and pathway databases
UniPathwayi | UPA00378 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ALG8Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000159063.12 |
HGNCi | HGNC:23161, ALG8 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane UniRule annotationARBA annotation; Multi-pass membrane protein UniRule annotationARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 6 – 32 | HelicalUniRule annotationAdd BLAST | 27 | |
Transmembranei | 53 – 77 | HelicalUniRule annotationAdd BLAST | 25 |
Keywords - Cellular componenti
Endoplasmic reticulumUniRule annotationARBA annotation, MembranePTM / Processingi
Proteomic databases
MaxQBi | H0YDD3 |
PeptideAtlasi | H0YDD3 |
PRIDEi | H0YDD3 |
ProteomicsDBi | 37356 |
Expressioni
Gene expression databases
Bgeei | ENSG00000159063, Expressed in right testis and 226 other tissues |
ExpressionAtlasi | H0YDD3, baseline and differential |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000153733 |
HOGENOMi | CLU_022045_0_1_1 |
Family and domain databases
InterProi | View protein in InterPro IPR039487, ALG8 IPR004856, Glyco_trans_ALG6/ALG8 |
PANTHERi | PTHR12413, PTHR12413, 1 hit PTHR12413:SF2, PTHR12413:SF2, 1 hit |
Pfami | View protein in Pfam PF03155, Alg6_Alg8, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 14 potential isoforms that are computationally mapped.Show allAlign All
H0YDD3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
KRHMEGAFLF AVLLHFKHIY LYVAPAYGVY LLRSYCFTAN KPDGSIRWKS
60 70 80 90 100
FSFVRVISLG LVVFLVSALS LGPFLALNQL PQVFSRLFPF KRGLCHAYWA
110 120 130 140 150
PNFWALYNAL DKVLSVIGLK LKFLDPNNIP KASMTSGLVQ QFQHTVLPSV
160 170 180 190 200
TPLATLICTL IAILVQAILL PQPPEYLGIQ PSIFCLWFKP QGPRGFLRCL
210 220
TLCALSSFMF GWHVHEKAIL LAILPM
Computationally mapped potential isoform sequencesi
There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9BVK2 | ALG8_HUMAN | Probable dolichyl pyrophosphate Glc... | ALG8 HUSSY-02 | 526 | Annotation score: | ||
H0YCV0 | H0YCV0_HUMAN | Alpha-1,3-glucosyltransferase | ALG8 | 228 | Annotation score: | ||
H0YD42 | H0YD42_HUMAN | Alpha-1,3-glucosyltransferase | ALG8 | 157 | Annotation score: | ||
H0YDQ1 | H0YDQ1_HUMAN | Alpha-1,3-glucosyltransferase | ALG8 | 87 | Annotation score: | ||
H0YDV4 | H0YDV4_HUMAN | Alpha-1,3-glucosyltransferase | ALG8 | 197 | Annotation score: | ||
E9PK79 | E9PK79_HUMAN | Alpha-1,3-glucosyltransferase | ALG8 | 242 | Annotation score: | ||
E9PKA5 | E9PKA5_HUMAN | Alpha-1,3-glucosyltransferase | ALG8 | 172 | Annotation score: | ||
E9PNE2 | E9PNE2_HUMAN | Alpha-1,3-glucosyltransferase | ALG8 | 236 | Annotation score: | ||
E9PP96 | E9PP96_HUMAN | Alpha-1,3-glucosyltransferase | ALG8 | 282 | Annotation score: | ||
H0YEE0 | H0YEE0_HUMAN | Alpha-1,3-glucosyltransferase | ALG8 | 281 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 | |
Non-terminal residuei | 226 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP002520 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000532440; ENSP00000433429; ENSG00000159063 |
UCSCi | uc058fvw.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP002520 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | H0YDD3 |
PeptideAtlasi | H0YDD3 |
PRIDEi | H0YDD3 |
ProteomicsDBi | 37356 |
Protocols and materials databases
Antibodypediai | 31296, 110 antibodies |
Genome annotation databases
Ensembli | ENST00000532440; ENSP00000433429; ENSG00000159063 |
UCSCi | uc058fvw.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000159063.12 |
HGNCi | HGNC:23161, ALG8 |
OpenTargetsi | ENSG00000159063 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000153733 |
HOGENOMi | CLU_022045_0_1_1 |
Enzyme and pathway databases
UniPathwayi | UPA00378 |
Miscellaneous databases
ChiTaRSi | ALG8, human |
Gene expression databases
Bgeei | ENSG00000159063, Expressed in right testis and 226 other tissues |
ExpressionAtlasi | H0YDD3, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR039487, ALG8 IPR004856, Glyco_trans_ALG6/ALG8 |
PANTHERi | PTHR12413, PTHR12413, 1 hit PTHR12413:SF2, PTHR12413:SF2, 1 hit |
Pfami | View protein in Pfam PF03155, Alg6_Alg8, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H0YDD3_HUMAN | |
Accessioni | H0YDD3Primary (citable) accession number: H0YDD3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 22, 2012 |
Last sequence update: | February 22, 2012 | |
Last modified: | October 7, 2020 | |
This is version 49 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |