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UniProtKB - H0YD17 (H0YD17_HUMAN)
Protein
CD44 antigen
Gene
CD44
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- hyaluronic acid binding Source: InterPro
GO - Biological processi
- cell adhesion Source: UniProtKB-KW
Keywordsi
Biological process | Cell adhesionARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: CD44 antigenARBA annotationAlternative name(s): Extracellular matrix receptor IIIARBA annotation GP90 lymphocyte homing/adhesion receptorARBA annotation HUTCH-IARBA annotation Hermes antigenARBA annotation Hyaluronate receptorARBA annotation Phagocytic glycoprotein 1ARBA annotation Phagocytic glycoprotein IARBA annotation |
Gene namesi | Name:CD44 |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1681, CD44 |
VEuPathDBi | HostDB:ENSG00000026508 |
Subcellular locationi
Other locations
- microvillus ARBA annotation
Plasma Membrane
- plasma membrane Source: UniProtKB-KW
Other locations
- integral component of membrane Source: InterPro
- microvillus Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membraneARBA annotation, Cell projectionARBA annotation, MembranePTM / Processingi
Keywords - PTMi
PhosphoproteinARBA annotationProteomic databases
PeptideAtlasi | H0YD17 |
PRIDEi | H0YD17 |
ProteomicsDBi | 37248 |
PTM databases
SwissPalmi | H0YD17 |
Expressioni
Gene expression databases
Bgeei | ENSG00000026508, Expressed in parotid gland and 242 other tissues |
ExpressionAtlasi | H0YD17, baseline and differential |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 57 | LinkInterPro annotationAdd BLAST | 57 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 93 – 123 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 201 – 229 | DisorderedSequence analysisAdd BLAST | 29 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 104 – 123 | Polar residuesSequence analysisAdd BLAST | 20 |
Phylogenomic databases
GeneTreei | ENSGT00530000063822 |
HOGENOMi | CLU_1217156_0_0_1 |
Family and domain databases
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR016186, C-type_lectin-like/link_sf IPR001231, CD44_antigen IPR043210, CD44_antigen-like IPR016187, CTDL_fold IPR000538, Link_dom |
PANTHERi | PTHR10225, PTHR10225, 1 hit PTHR10225:SF6, PTHR10225:SF6, 1 hit |
Pfami | View protein in Pfam PF00193, Xlink, 1 hit |
PRINTSi | PR00658, CD44 PR01265, LINKMODULE |
SMARTi | View protein in SMART SM00445, LINK, 1 hit |
SUPFAMi | SSF56436, SSF56436, 1 hit |
PROSITEi | View protein in PROSITE PS50963, LINK_2, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 19 potential isoforms that are computationally mapped.Show allAlign All
H0YD17-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
XQMEKALSIG FETCRYGFIE GHVVIPRIHP NSICAANNTG VYILTSNTSQ
60 70 80 90 100
YDTYCFNASA PPEEDCTSVT DLPNAFDGPI TITIVNRDGT RYVQKGEYRT
110 120 130 140 150
NPEDIYPSNP TDDDVSSGSS SERSSTSGGY IFYTFSTVHP IPDEDSPWIT
160 170 180 190 200
DSTDRIPATI STTPRAFDHT KQNQDWTQWN PSHSNPEVLL QTTTRMTDVD
210 220
RNGTTAYEGN WNPEAHPPLI HHEHHEEEE
Computationally mapped potential isoform sequencesi
There are 19 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP16070 | CD44_HUMAN | CD44 antigen | CD44 LHR, MDU2, MDU3, MIC4 | 742 | Annotation score: | ||
H0Y5E4 | H0Y5E4_HUMAN | CD44 antigen | CD44 | 294 | Annotation score: | ||
H0YCV9 | H0YCV9_HUMAN | CD44 antigen | CD44 | 277 | Annotation score: | ||
H0Y2P0 | H0Y2P0_HUMAN | CD44 antigen | CD44 | 287 | Annotation score: | ||
H0YD13 | H0YD13_HUMAN | CD44 antigen | CD44 | 206 | Annotation score: | ||
H0YDX6 | H0YDX6_HUMAN | CD44 antigen | CD44 | 183 | Annotation score: | ||
H0YDW7 | H0YDW7_HUMAN | CD44 antigen | CD44 | 240 | Annotation score: | ||
E9PKC6 | E9PKC6_HUMAN | CD44 antigen | CD44 | 78 | Annotation score: | ||
Q86UZ1 | Q86UZ1_HUMAN | CD44 antigen | CD44 | 80 | Annotation score: | ||
H0YD90 | H0YD90_HUMAN | Extracellular matrix receptor III | CD44 | 195 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | 1 | ||
Non-terminal residuei | 229 | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL133330 Genomic DNA No translation available. AL136989 Genomic DNA No translation available. AL356215 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000528455.5; ENSP00000432718.1; ENSG00000026508.21 |
UCSCi | uc058aiu.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL133330 Genomic DNA No translation available. AL136989 Genomic DNA No translation available. AL356215 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
PTM databases
SwissPalmi | H0YD17 |
Proteomic databases
PeptideAtlasi | H0YD17 |
PRIDEi | H0YD17 |
ProteomicsDBi | 37248 |
Protocols and materials databases
Antibodypediai | 804, 5420 antibodies from 58 providers |
Genome annotation databases
Ensembli | ENST00000528455.5; ENSP00000432718.1; ENSG00000026508.21 |
UCSCi | uc058aiu.1, human |
Organism-specific databases
HGNCi | HGNC:1681, CD44 |
OpenTargetsi | ENSG00000026508 |
VEuPathDBi | HostDB:ENSG00000026508 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00530000063822 |
HOGENOMi | CLU_1217156_0_0_1 |
Miscellaneous databases
ChiTaRSi | CD44, human |
Gene expression databases
Bgeei | ENSG00000026508, Expressed in parotid gland and 242 other tissues |
ExpressionAtlasi | H0YD17, baseline and differential |
Family and domain databases
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR016186, C-type_lectin-like/link_sf IPR001231, CD44_antigen IPR043210, CD44_antigen-like IPR016187, CTDL_fold IPR000538, Link_dom |
PANTHERi | PTHR10225, PTHR10225, 1 hit PTHR10225:SF6, PTHR10225:SF6, 1 hit |
Pfami | View protein in Pfam PF00193, Xlink, 1 hit |
PRINTSi | PR00658, CD44 PR01265, LINKMODULE |
SMARTi | View protein in SMART SM00445, LINK, 1 hit |
SUPFAMi | SSF56436, SSF56436, 1 hit |
PROSITEi | View protein in PROSITE PS50963, LINK_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | H0YD17_HUMAN | |
Accessioni | H0YD17Primary (citable) accession number: H0YD17 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 22, 2012 |
Last sequence update: | October 5, 2016 | |
Last modified: | May 25, 2022 | |
This is version 67 of the entry and version 8 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |