UniProtKB - H0YCN5 (H0YCN5_HUMAN)
Protein
Submitted name:
Phospholipid-transporting ATPase ABCA7
Gene
ABCA7
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 272 – 279 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATPase-coupled transmembrane transporter activity Source: InterPro
- ATP binding Source: UniProtKB-UniRule
Keywordsi
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Submitted name: Phospholipid-transporting ATPase ABCA7Imported |
Gene namesi | Name:ABCA7Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:37, ABCA7 |
VEuPathDBi | HostDB:ENSG00000064687.12 |
Subcellular locationi
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 41 – 68 | HelicalSequence analysisAdd BLAST | 28 | |
Transmembranei | 80 – 105 | HelicalSequence analysisAdd BLAST | 26 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000064687, Expressed in adenohypophysis and 192 other tissues |
ExpressionAtlasi | H0YCN5, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 238 – 470 | ABC transporterInterPro annotationAdd BLAST | 233 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 549 – 591 | DisorderedSequence analysisAdd BLAST | 43 |
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000161439 |
HOGENOMi | CLU_000604_19_5_1 |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like IPR026082, ABCA IPR030369, ABCA7 IPR027417, P-loop_NTPase |
PANTHERi | PTHR19229, PTHR19229, 1 hit PTHR19229:SF49, PTHR19229:SF49, 1 hit |
Pfami | View protein in Pfam PF00005, ABC_tran, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50893, ABC_TRANSPORTER_2, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
H0YCN5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
XSICVVFAMS FVPASFTLVL IEERVTRAKH LQLMGGLSPT LYWLGNFLWD
60 70 80 90 100
MCNYLVPACI VVLIFLAFQQ RAYVAPANLP ALLLLLLLYG TAYVVLTCIN
110 120 130 140 150
LFIGINGSMA TFVLELFSDQ KLQEVSRILK QVFLIFPHFC LGRGLIDMVR
160 170 180 190 200
NQAMADAFER LGDRQFQSPL RWEVVGKNLL AMVIQGPLFL LFTLLLQHRS
210 220 230 240 250
QLLPQPRVRS LPLLGEEDED VARERERVVQ GATQGDVLVL RNLTKVYRGQ
260 270 280 290 300
RMPAVDRLCL GIPPGECFGL LGVNGAGKTS TFRMVTGDTL ASRGEAVLAG
310 320 330 340 350
HSVAREPSAA HLSMGYCPQS DAIFELLTGR EHLELLARLR GVPEAQVAQT
360 370 380 390 400
AGSGLARLGL SWYADRPAGT YSGGNKRKLA TALALVGDPA VVFLDEPTTG
410 420 430 440 450
MDPSARRFLW NSLLAVVREG RSVMLTSHSM EECEALCSRL AIMVNGRFRC
460 470 480 490 500
LGSPQHLKGR FAAGHTLTLR VPAARSQPAA AFVAAEFPGA ELREAHGGRL
510 520 530 540 550
RFQLPPGGRC ALARVFGELA VHGAEHGVED FSVSQTMLEE VFLYFSKDQG
560 570 580 590
KDEDTEEQKE AGVGVDPAPG LQHPKRVSQF LDDPSTAETV L
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8IZY2 | ABCA7_HUMAN | Phospholipid-transporting ATPase AB... | ABCA7 | 2,146 | Annotation score: | ||
A0A6E1ZGS3 | A0A6E1ZGS3_HUMAN | Phospholipid-transporting ATPase AB... | ABCA7 | 533 | Annotation score: | ||
A0A087WZX6 | A0A087WZX6_HUMAN | Phospholipid-transporting ATPase AB... | ABCA7 | 280 | Annotation score: | ||
A0A087WX86 | A0A087WX86_HUMAN | Phospholipid-transporting ATPase AB... | ABCA7 | 96 | Annotation score: | ||
E9PKG5 | E9PKG5_HUMAN | Phospholipid-transporting ATPase AB... | ABCA7 | 136 | Annotation score: | ||
E9PL63 | E9PL63_HUMAN | Phospholipid-transporting ATPase AB... | ABCA7 | 164 | Annotation score: | ||
H0YF58 | H0YF58_HUMAN | Phospholipid-transporting ATPase AB... | ABCA7 | 62 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC011558 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000525073; ENSP00000432031; ENSG00000064687 |
UCSCi | uc060qui.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC011558 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
Proteomic databases
MaxQBi | H0YCN5 |
PeptideAtlasi | H0YCN5 |
ProteomicsDBi | 37122 |
Protocols and materials databases
Antibodypediai | 22516, 169 antibodies |
Genome annotation databases
Ensembli | ENST00000525073; ENSP00000432031; ENSG00000064687 |
UCSCi | uc060qui.1, human |
Organism-specific databases
HGNCi | HGNC:37, ABCA7 |
NIAGADSi | ENSG00000064687 |
OpenTargetsi | ENSG00000064687 |
VEuPathDBi | HostDB:ENSG00000064687.12 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000161439 |
HOGENOMi | CLU_000604_19_5_1 |
Miscellaneous databases
ChiTaRSi | ABCA7, human |
Gene expression databases
Bgeei | ENSG00000064687, Expressed in adenohypophysis and 192 other tissues |
ExpressionAtlasi | H0YCN5, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like IPR026082, ABCA IPR030369, ABCA7 IPR027417, P-loop_NTPase |
PANTHERi | PTHR19229, PTHR19229, 1 hit PTHR19229:SF49, PTHR19229:SF49, 1 hit |
Pfami | View protein in Pfam PF00005, ABC_tran, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50893, ABC_TRANSPORTER_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H0YCN5_HUMAN | |
Accessioni | H0YCN5Primary (citable) accession number: H0YCN5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 22, 2012 |
Last sequence update: | January 9, 2013 | |
Last modified: | February 10, 2021 | |
This is version 57 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |