UniProtKB - H0YC99 (H0YC99_HUMAN)
Protein
Submitted name:
Latent-transforming growth factor beta-binding protein 3
Gene
LTBP3
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- calcium ion binding Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Latent-transforming growth factor beta-binding protein 3Imported |
Gene namesi | Name:LTBP3Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000168056.14 |
HGNCi | HGNC:6716, LTBP3 |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix ARBA annotation
Keywords - Cellular componenti
Extracellular matrixARBA annotation, SecretedPTM / Processingi
Keywords - PTMi
Disulfide bondARBA annotationProteomic databases
MaxQBi | H0YC99 |
PeptideAtlasi | H0YC99 |
PRIDEi | H0YC99 |
ProteomicsDBi | 36992 |
Expressioni
Gene expression databases
Bgeei | ENSG00000168056, Expressed in descending thoracic aorta and 235 other tissues |
ExpressionAtlasi | H0YC99, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 54 – 106 | TBInterPro annotationAdd BLAST | 53 | |
Domaini | 225 – 266 | EGF-likeInterPro annotationAdd BLAST | 42 | |
Domaini | 267 – 304 | EGF-likeInterPro annotationAdd BLAST | 38 | |
Domaini | 311 – 353 | EGF-likeInterPro annotationAdd BLAST | 43 | |
Domaini | 395 – 435 | EGF-likeInterPro annotationAdd BLAST | 41 | |
Domaini | 436 – 476 | EGF-likeInterPro annotationAdd BLAST | 41 | |
Domaini | 477 – 516 | EGF-likeInterPro annotationAdd BLAST | 40 | |
Domaini | 517 – 559 | EGF-likeInterPro annotationAdd BLAST | 43 | |
Domaini | 568 – 622 | TBInterPro annotationAdd BLAST | 55 | |
Domaini | 644 – 686 | EGF-likeInterPro annotationAdd BLAST | 43 | |
Domaini | 687 – 727 | EGF-likeInterPro annotationAdd BLAST | 41 | |
Domaini | 740 – 790 | TBInterPro annotationAdd BLAST | 51 | |
Domaini | 858 – 898 | EGF-likeInterPro annotationAdd BLAST | 41 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 126 – 208 | DisorderedSequence analysisAdd BLAST | 83 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 138 – 152 | Pro-richSequence analysisAdd BLAST | 15 | |
Compositional biasi | 168 – 185 | PolarSequence analysisAdd BLAST | 18 |
Keywords - Domaini
EGF-like domainPROSITE-ProRule annotationARBA annotation, SignalARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000160285 |
HOGENOMi | CLU_346686_0_0_1 |
Family and domain databases
Gene3Di | 3.90.290.10, 3 hits |
InterProi | View protein in InterPro IPR026823, cEGF IPR001881, EGF-like_Ca-bd_dom IPR013032, EGF-like_CS IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR009030, Growth_fac_rcpt_cys_sf IPR017878, TB_dom IPR036773, TB_dom_sf |
Pfami | View protein in Pfam PF12662, cEGF, 2 hits PF07645, EGF_CA, 7 hits PF12661, hEGF, 1 hit PF00683, TB, 3 hits |
SMARTi | View protein in SMART SM00181, EGF, 12 hits SM00179, EGF_CA, 12 hits |
SUPFAMi | SSF57184, SSF57184, 3 hits SSF57581, SSF57581, 3 hits |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 9 hits PS01186, EGF_2, 6 hits PS50026, EGF_3, 10 hits PS01187, EGF_CA, 4 hits PS51364, TB, 3 hits |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All
H0YC99-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
XFAPVICKRT CLKGQCRDSC QQGSNMTLIG ENGHSTDTLT GSGFRVADKP
60 70 80 90 100
EEKSLCFRLV SPEHQCQHPL TTRLTRQLCC CSVGKAWGAR CQRCPTDGTA
110 120 130 140 150
AFKEICPAGK GYHILTSHQT LTIQGESDFS LFLHPDGPPK PQQLPESPSQ
160 170 180 190 200
APPPEDTEEE RGVTTDSPVS EERSVQQSHP TATTTPARPY PELISRPSPP
210 220 230 240 250
TMRWFLPDLP PSRSAVEIAP TQVTETDECR LNQNICGHGE CVPGPPDYSC
260 270 280 290 300
HCNPGYRSHP QHRYCVDVNE CEAEPCGPGR GICMNTGGSY NCHCNRGYRL
310 320 330 340 350
HVGAGGRSCV DLNECAKPHL CGDGGFCINF PGHYKCNCYP GYRLKASRPP
360 370 380 390 400
VCEDIDECRD PSSCPDGKCE NKPGSFKCIA CQPGYRSQGG GACRDVNECA
410 420 430 440 450
EGSPCSPGWC ENLPGSFRCT CAQGYAPAPD GRSCLDVDEC EAGDVCDNGI
460 470 480 490 500
CSNTPGSFQC QCLSGYHLSR DRSHCEDIDE CDFPAACIGG DCINTNGSYR
510 520 530 540 550
CLCPQGHRLV GGRKCQDIDE CSQDPSLCLP HGACKNLQGS YVCVCDEGFT
560 570 580 590 600
PTQDQHGCEE VEQPHHKKEC YLNFDDTVFC DSVLATNVTQ QECCCSLGAG
610 620 630 640 650
WGDHCEIYPC PVYSSAEFHS LCPDGKGYTQ DNNIVNYGIP AHRDIDECML
660 670 680 690 700
FGSEICKEGK CVNTQPGYEC YCKQGFYYDG NLLECVDVDE CLDESNCRNG
710 720 730 740 750
VCENTRGGYR CACTPPAEYS PAQRQCLSPE EMERAPERRD VCWSQRGEDG
760 770 780 790 800
MCAGPLAGPA LTFDDCCCRQ GRGWGAQCRP CPPRGAGSHC PTSQSESNSF
810 820 830 840 850
WDTSPLLLGK PPRDEDSSEE DSDECRCVSG RCVPRPGGAV CECPGGFQLD
860 870 880 890 900
ASRARCVDID ECRELNQRGL LCKSERCVNT SGSFRCVCKA GFARSRPHGA
CVPQRRR
Computationally mapped potential isoform sequencesi
There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9NS15 | LTBP3_HUMAN | Latent-transforming growth factor b... | LTBP3 | 1,303 | Annotation score: | ||
E9PKW1 | E9PKW1_HUMAN | Latent-transforming growth factor b... | LTBP3 | 1,136 | Annotation score: | ||
E9PJR2 | E9PJR2_HUMAN | Latent-transforming growth factor b... | LTBP3 | 733 | Annotation score: | ||
E9PQR0 | E9PQR0_HUMAN | Latent-transforming growth factor b... | LTBP3 | 259 | Annotation score: | ||
E9PPT7 | E9PPT7_HUMAN | Latent-transforming growth factor b... | LTBP3 | 221 | Annotation score: | ||
E9PR84 | E9PR84_HUMAN | Latent-transforming growth factor b... | LTBP3 | 306 | Annotation score: | ||
H0YCQ2 | H0YCQ2_HUMAN | Latent-transforming growth factor b... | LTBP3 | 140 | Annotation score: | ||
E9PR75 | E9PR75_HUMAN | Latent-transforming growth factor b... | LTBP3 | 123 | Annotation score: | ||
H0YE75 | H0YE75_HUMAN | Latent-transforming growth factor b... | LTBP3 | 69 | Annotation score: | ||
E9PRF2 | E9PRF2_HUMAN | Latent-transforming growth factor b... | LTBP3 | 116 | Annotation score: | ||
There is more potential isoformShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP000769 Genomic DNA No translation available. AP001362 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000526927; ENSP00000431219; ENSG00000168056 |
UCSCi | uc058dlf.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP000769 Genomic DNA No translation available. AP001362 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
Proteomic databases
MaxQBi | H0YC99 |
PeptideAtlasi | H0YC99 |
PRIDEi | H0YC99 |
ProteomicsDBi | 36992 |
Protocols and materials databases
Antibodypediai | 70903, 6 antibodies |
Genome annotation databases
Ensembli | ENST00000526927; ENSP00000431219; ENSG00000168056 |
UCSCi | uc058dlf.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000168056.14 |
HGNCi | HGNC:6716, LTBP3 |
OpenTargetsi | ENSG00000168056 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000160285 |
HOGENOMi | CLU_346686_0_0_1 |
Miscellaneous databases
ChiTaRSi | LTBP3, human |
Gene expression databases
Bgeei | ENSG00000168056, Expressed in descending thoracic aorta and 235 other tissues |
ExpressionAtlasi | H0YC99, baseline and differential |
Family and domain databases
Gene3Di | 3.90.290.10, 3 hits |
InterProi | View protein in InterPro IPR026823, cEGF IPR001881, EGF-like_Ca-bd_dom IPR013032, EGF-like_CS IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR009030, Growth_fac_rcpt_cys_sf IPR017878, TB_dom IPR036773, TB_dom_sf |
Pfami | View protein in Pfam PF12662, cEGF, 2 hits PF07645, EGF_CA, 7 hits PF12661, hEGF, 1 hit PF00683, TB, 3 hits |
SMARTi | View protein in SMART SM00181, EGF, 12 hits SM00179, EGF_CA, 12 hits |
SUPFAMi | SSF57184, SSF57184, 3 hits SSF57581, SSF57581, 3 hits |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 9 hits PS01186, EGF_2, 6 hits PS50026, EGF_3, 10 hits PS01187, EGF_CA, 4 hits PS51364, TB, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H0YC99_HUMAN | |
Accessioni | H0YC99Primary (citable) accession number: H0YC99 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 22, 2012 |
Last sequence update: | February 22, 2012 | |
Last modified: | December 2, 2020 | |
This is version 60 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |