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Protein
Submitted name:

Vacuolar protein sorting-associated protein 37A

Gene

VPS37A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Keywordsi

Biological processProtein transportPROSITE-ProRule annotation, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Vacuolar protein sorting-associated protein 37AImported
Gene namesi
Name:VPS37AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000155975.9
HGNCiHGNC:24928 VPS37A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000155975

PTM / Processingi

Proteomic databases

MaxQBiH0YBN0
PeptideAtlasiH0YBN0
PRIDEiH0YBN0

Expressioni

Gene expression databases

BgeeiENSG00000155975 Expressed in 199 organ(s), highest expression level in corpus callosum
ExpressionAtlasiH0YBN0 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH0YBN0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini81 – 170VPS37 C-terminalInterPro annotationAdd BLAST90

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili35 – 55Sequence analysisAdd BLAST21
Coiled coili100 – 120Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG3270 Eukaryota
ENOG4111UJN LUCA
GeneTreeiENSGT00530000063123

Family and domain databases

Gene3Di1.10.287.660, 1 hit
InterProiView protein in InterPro
IPR037202 ESCRT_assembly_dom
IPR029012 Helix_hairpin_bin_sf
IPR009851 Mod_r
IPR037859 Vps37
PANTHERiPTHR13678 PTHR13678, 1 hit
PfamiView protein in Pfam
PF07200 Mod_r, 1 hit
SUPFAMiSSF140111 SSF140111, 1 hit
PROSITEiView protein in PROSITE
PS51314 VPS37_C, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

H0YBN0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
PDAFPELSEL SVSQLTDMNE QEEVLLEQFL TLPQLKQIIT DKDDLVKSIE
60 70 80 90 100
ELARKNLLLE PSLEAKRQTV LDKYELLTQM KSTFEKKMQR QHELSESCSA
110 120 130 140 150
SALQARLKVA AHEAEEESDN IAEDFLEGKM EIDDFLSSFM EKRTICHCRR
160 170
AKEEKLQQAI AMHSQFHAPL
Length:170
Mass (Da):19,607
Last modified:February 22, 2012 - v1
Checksum:i088E23913D6E48B2
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8NEZ2VP37A_HUMAN
Vacuolar protein sorting-associated...
VPS37A HCRP1
397Annotation score:
E5RG91E5RG91_HUMAN
Vacuolar protein sorting-associated...
VPS37A
317Annotation score:
E5RHB8E5RHB8_HUMAN
Vacuolar protein sorting-associated...
VPS37A
76Annotation score:
E5RJX6E5RJX6_HUMAN
Vacuolar protein sorting-associated...
VPS37A
116Annotation score:
E5RJ10E5RJ10_HUMAN
Vacuolar protein sorting-associated...
VPS37A
53Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091050 Genomic DNA No translation available.
AC124074 Genomic DNA No translation available.
AC142097 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000521976; ENSP00000429858; ENSG00000155975
UCSCiuc064knh.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091050 Genomic DNA No translation available.
AC124074 Genomic DNA No translation available.
AC142097 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH0YBN0
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiH0YBN0
PeptideAtlasiH0YBN0
PRIDEiH0YBN0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000521976; ENSP00000429858; ENSG00000155975
UCSCiuc064knh.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000155975.9
HGNCiHGNC:24928 VPS37A
OpenTargetsiENSG00000155975
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3270 Eukaryota
ENOG4111UJN LUCA
GeneTreeiENSGT00530000063123

Miscellaneous databases

ChiTaRSiVPS37A human

Gene expression databases

BgeeiENSG00000155975 Expressed in 199 organ(s), highest expression level in corpus callosum
ExpressionAtlasiH0YBN0 baseline and differential

Family and domain databases

Gene3Di1.10.287.660, 1 hit
InterProiView protein in InterPro
IPR037202 ESCRT_assembly_dom
IPR029012 Helix_hairpin_bin_sf
IPR009851 Mod_r
IPR037859 Vps37
PANTHERiPTHR13678 PTHR13678, 1 hit
PfamiView protein in Pfam
PF07200 Mod_r, 1 hit
SUPFAMiSSF140111 SSF140111, 1 hit
PROSITEiView protein in PROSITE
PS51314 VPS37_C, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH0YBN0_HUMAN
AccessioniPrimary (citable) accession number: H0YBN0
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: September 12, 2018
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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