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Entry version 64 (12 Aug 2020)
Sequence version 1 (22 Feb 2012)
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Protein
Submitted name:

Matrilin-2

Gene

MATN2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Matrilin-2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MATN2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000132561.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6908, MATN2

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000132561

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondARBA annotation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
H0YBJ4

PeptideAtlas

More...
PeptideAtlasi
H0YBJ4

PRoteomics IDEntifications database

More...
PRIDEi
H0YBJ4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
36742

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000132561, Expressed in tibia and 241 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
H0YBJ4, baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 60VWFAInterPro annotationAdd BLAST60
Domaini103 – 143EGF-likeInterPro annotationAdd BLAST41
Domaini144 – 184EGF-likeInterPro annotationAdd BLAST41
Domaini185 – 225EGF-likeInterPro annotationAdd BLAST41
Domaini349 – 389EGF-likeInterPro annotationAdd BLAST41
Domaini438 – 613VWFAInterPro annotationAdd BLAST176

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili689 – 716Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysisARBA annotation, EGF-like domainPROSITE-ProRule annotationARBA annotation, RepeatARBA annotation, SignalARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158008

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.5.30, 1 hit
3.40.50.410, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026823, cEGF
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR009030, Growth_fac_rcpt_cys_sf
IPR030747, Matrilin-2
IPR036337, Matrilin_cc_sf
IPR019466, Matrilin_coiled-coil_trimer
IPR002035, VWF_A
IPR036465, vWFA_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR24020:SF35, PTHR24020:SF35, 6 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12662, cEGF, 1 hit
PF07645, EGF_CA, 1 hit
PF10393, Matrilin_ccoil, 1 hit
PF00092, VWA, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 9 hits
SM00179, EGF_CA, 9 hits
SM01279, Matrilin_ccoil, 1 hit
SM00327, VWA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53300, SSF53300, 2 hits
SSF57184, SSF57184, 3 hits
SSF58002, SSF58002, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010, ASX_HYDROXYL, 4 hits
PS01186, EGF_2, 6 hits
PS50026, EGF_3, 4 hits
PS50234, VWFA, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

H0YBJ4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XAEVAAKARD TGILIFAIGV GQVDFNTLKS IGSEPHEDHV FLVANFSQIE
60 70 80 90 100
TLTSVFQKKL CTAHMCSTLE HNCAHFCINI PGSYVCRCKQ GYILNSDQTT
110 120 130 140 150
CRTVDYCASE NHGCEHECVN ADGSYLCQCH EGFALNPDKK TCTKIDYCAS
160 170 180 190 200
SNHGCQHECV NTDDSYSCHC LKGFTLNPDK KTCRRINYCA LNKPGCEHEC
210 220 230 240 250
VNMEESYYCR CHRGYTLDPN GKTCSRVDHC AQQDHGCEQL CLNTEDSFVC
260 270 280 290 300
QCSEGFLINE DLKTCSRVDY CLLSDHGCEY SCVNMDRSFA CQCPEGHVLR
310 320 330 340 350
SDGKTCAKLD SCALGDHGCE HSCVSSEDSF VCQCFEGYIL REDGKTCRRK
360 370 380 390 400
DVCQAIDHGC EHICVNSDDS YTCECLEGFR LAEDGKRCRR KDVCKSTHHG
410 420 430 440 450
CEHICVNNGN SYICKCSEGF VLAEDGRRCK KCTEGPIDLV FVIDGSKSLG
460 470 480 490 500
EENFEVVKQF VTGIIDSLTI SPKAARVGLL QYSTQVHTEF TLRNFNSAKD
510 520 530 540 550
MKKAVAHMKY MGKGSMTGLA LKHMFERSFT QGEGARPLST RVPRAAIVFT
560 570 580 590 600
DGRAQDDVSE WASKAKANGI TMYAVGVGKA IEEELQEIAS EPTNKHLFYA
610 620 630 640 650
EDFSTMDEIS EKLKKGICEA LEDSDGRQDS PAGELPKTVQ QPTVQHRYLF
660 670 680 690 700
EEDNLLRSTQ KLSHSTKPSG SPLEEKHDQC KCENLIMFQN LANEEVRKLT
710 720
QRLEEMTQRM EALENRLRYR
Length:720
Mass (Da):80,569
Last modified:February 22, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i915370D2E71448D5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O00339MATN2_HUMAN
Matrilin-2
MATN2 UNQ193/PRO219
956Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBM3H0YBM3_HUMAN
Matrilin-2
MATN2
195Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBV5H0YBV5_HUMAN
Matrilin-2
MATN2
181Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBN2H0YBN2_HUMAN
Matrilin-2
MATN2
183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJM4E5RJM4_HUMAN
Matrilin-2
MATN2
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBD5H0YBD5_HUMAN
Matrilin-2
MATN2
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBF2H0YBF2_HUMAN
Matrilin-2
MATN2
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBU5H0YBU5_HUMAN
Matrilin-2
MATN2
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AP002906 Genomic DNA No translation available.
AP003352 Genomic DNA No translation available.
KC877283 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000518154; ENSP00000429622; ENSG00000132561

UCSC genome browser

More...
UCSCi
uc064ovr.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002906 Genomic DNA No translation available.
AP003352 Genomic DNA No translation available.
KC877283 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Proteomic databases

MaxQBiH0YBJ4
PeptideAtlasiH0YBJ4
PRIDEiH0YBJ4
ProteomicsDBi36742

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
26033, 172 antibodies

Genome annotation databases

EnsembliENST00000518154; ENSP00000429622; ENSG00000132561
UCSCiuc064ovr.1, human

Organism-specific databases

EuPathDBiHostDB:ENSG00000132561.13
HGNCiHGNC:6908, MATN2
OpenTargetsiENSG00000132561

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000158008

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MATN2, human

Gene expression databases

BgeeiENSG00000132561, Expressed in tibia and 241 other tissues
ExpressionAtlasiH0YBJ4, baseline and differential

Family and domain databases

Gene3Di1.20.5.30, 1 hit
3.40.50.410, 2 hits
InterProiView protein in InterPro
IPR026823, cEGF
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR009030, Growth_fac_rcpt_cys_sf
IPR030747, Matrilin-2
IPR036337, Matrilin_cc_sf
IPR019466, Matrilin_coiled-coil_trimer
IPR002035, VWF_A
IPR036465, vWFA_dom_sf
PANTHERiPTHR24020:SF35, PTHR24020:SF35, 6 hits
PfamiView protein in Pfam
PF12662, cEGF, 1 hit
PF07645, EGF_CA, 1 hit
PF10393, Matrilin_ccoil, 1 hit
PF00092, VWA, 2 hits
SMARTiView protein in SMART
SM00181, EGF, 9 hits
SM00179, EGF_CA, 9 hits
SM01279, Matrilin_ccoil, 1 hit
SM00327, VWA, 1 hit
SUPFAMiSSF53300, SSF53300, 2 hits
SSF57184, SSF57184, 3 hits
SSF58002, SSF58002, 1 hit
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 4 hits
PS01186, EGF_2, 6 hits
PS50026, EGF_3, 4 hits
PS50234, VWFA, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH0YBJ4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H0YBJ4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: August 12, 2020
This is version 64 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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