UniProtKB - H0YBJ0 (H0YBJ0_HUMAN)
Protein
DNA polymerase
Gene
POLB
Organism
Homo sapiens (Human)
Status
Functioni
DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.UniRule annotation
Catalytic activityi
- EC:2.7.7.7UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 3 | Schiff-base intermediate with DNAUniRule annotation | 1 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-UniRule
- DNA-directed DNA polymerase activity Source: UniProtKB-UniRule
- metal ion binding Source: UniProtKB-UniRule
GO - Biological processi
- DNA repair Source: UniProtKB-KW
- DNA replication Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-directed DNA polymeraseUniRule annotation, Nucleotidyltransferase, Transferase |
Biological process | DNA damage, DNA repairUniRule annotation, DNA replicationARBA annotation, DNA synthesisARBA annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:POLBImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000070501.11 |
HGNCi | HGNC:9174, POLB |
Subcellular locationi
Keywords - Cellular componenti
NucleusUniRule annotationPTM / Processingi
Proteomic databases
MaxQBi | H0YBJ0 |
PeptideAtlasi | H0YBJ0 |
PRIDEi | H0YBJ0 |
ProteomicsDBi | 36738 |
Expressioni
Gene expression databases
Bgeei | ENSG00000070501, Expressed in cerebellar hemisphere and 236 other tissues |
ExpressionAtlasi | H0YBJ0, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 236 | POLXcInterPro annotationAdd BLAST | 236 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00940000156918 |
HOGENOMi | CLU_008698_1_1_1 |
Family and domain databases
CDDi | cd00141, NT_POLXc, 1 hit |
Gene3Di | 3.30.210.10, 1 hit 3.30.460.10, 2 hits |
InterProi | View protein in InterPro IPR002054, DNA-dir_DNA_pol_X IPR019843, DNA_pol-X_BS IPR028207, DNA_pol_B_palm_palm IPR018944, DNA_pol_lambd_fingers_domain IPR037160, DNA_Pol_thumb_sf IPR022312, DNA_pol_X IPR002008, DNA_pol_X_beta-like IPR043519, NT_sf IPR029398, PolB_thumb |
Pfami | View protein in Pfam PF14792, DNA_pol_B_palm, 1 hit PF14791, DNA_pol_B_thumb, 1 hit PF10391, DNA_pol_lambd_f, 1 hit |
PRINTSi | PR00869, DNAPOLX PR00870, DNAPOLXBETA |
SMARTi | View protein in SMART SM00483, POLXc, 1 hit |
SUPFAMi | SSF81301, SSF81301, 1 hit |
PROSITEi | View protein in PROSITE PS00522, DNA_POLYMERASE_X, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All
H0YBJ0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
XEKIDEFLAT GKLRKLEKIR QDDTSSSINF LTRVSGIGPS AARKFVDEGI
60 70 80 90 100
KTLEDLRKNE DKLNHHQRIG LKYFGDFEKR IPREEMLQMQ DIVLNEVKKV
110 120 130 140 150
DSEYIATVCG SFRRGAESSG DMDVLLTHPS FTSESTKQGV CQLPSKNDEK
160 170 180 190 200
EYPHRRIDIR LIPKDQYYCG VLYFTGSDIF NKNMRAHALE KGFTINEYTI
210 220 230
RPLGVTGVAG EPLPVDSEKD IFDYIQWKYR EPKDRSE
Computationally mapped potential isoform sequencesi
There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP06746 | DPOLB_HUMAN | DNA polymerase beta | POLB | 335 | Annotation score: | ||
E5RIJ0 | E5RIJ0_HUMAN | DNA polymerase | POLB | 193 | Annotation score: | ||
H0YBX1 | H0YBX1_HUMAN | DNA polymerase | POLB | 239 | Annotation score: | ||
E7EW18 | E7EW18_HUMAN | DNA polymerase beta | POLB | 280 | Annotation score: | ||
E5RJ55 | E5RJ55_HUMAN | DNA polymerase beta | POLB | 51 | Annotation score: | ||
E9PIC6 | E9PIC6_HUMAN | DNA polymerase beta | POLB | 38 | Annotation score: | ||
E5RHZ4 | E5RHZ4_HUMAN | DNA polymerase beta | POLB | 54 | Annotation score: | ||
H0YAV8 | H0YAV8_HUMAN | DNA polymerase beta | POLB | 106 | Annotation score: | ||
E5RG65 | E5RG65_HUMAN | DNA polymerase beta | POLB | 42 | Annotation score: | ||
H0YB29 | H0YB29_HUMAN | DNA polymerase beta | POLB | 29 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC083973 Genomic DNA No translation available. AC107885 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000521290; ENSP00000429597; ENSG00000070501 |
UCSCi | uc064mln.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC083973 Genomic DNA No translation available. AC107885 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
Proteomic databases
MaxQBi | H0YBJ0 |
PeptideAtlasi | H0YBJ0 |
PRIDEi | H0YBJ0 |
ProteomicsDBi | 36738 |
Protocols and materials databases
Antibodypediai | 3175, 388 antibodies |
Genome annotation databases
Ensembli | ENST00000521290; ENSP00000429597; ENSG00000070501 |
UCSCi | uc064mln.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000070501.11 |
HGNCi | HGNC:9174, POLB |
OpenTargetsi | ENSG00000070501 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000156918 |
HOGENOMi | CLU_008698_1_1_1 |
Miscellaneous databases
ChiTaRSi | POLB, human |
Gene expression databases
Bgeei | ENSG00000070501, Expressed in cerebellar hemisphere and 236 other tissues |
ExpressionAtlasi | H0YBJ0, baseline and differential |
Family and domain databases
CDDi | cd00141, NT_POLXc, 1 hit |
Gene3Di | 3.30.210.10, 1 hit 3.30.460.10, 2 hits |
InterProi | View protein in InterPro IPR002054, DNA-dir_DNA_pol_X IPR019843, DNA_pol-X_BS IPR028207, DNA_pol_B_palm_palm IPR018944, DNA_pol_lambd_fingers_domain IPR037160, DNA_Pol_thumb_sf IPR022312, DNA_pol_X IPR002008, DNA_pol_X_beta-like IPR043519, NT_sf IPR029398, PolB_thumb |
Pfami | View protein in Pfam PF14792, DNA_pol_B_palm, 1 hit PF14791, DNA_pol_B_thumb, 1 hit PF10391, DNA_pol_lambd_f, 1 hit |
PRINTSi | PR00869, DNAPOLX PR00870, DNAPOLXBETA |
SMARTi | View protein in SMART SM00483, POLXc, 1 hit |
SUPFAMi | SSF81301, SSF81301, 1 hit |
PROSITEi | View protein in PROSITE PS00522, DNA_POLYMERASE_X, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H0YBJ0_HUMAN | |
Accessioni | H0YBJ0Primary (citable) accession number: H0YBJ0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 22, 2012 |
Last sequence update: | February 22, 2012 | |
Last modified: | December 2, 2020 | |
This is version 54 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |