UniProtKB - H0YBG8 (H0YBG8_HUMAN)
Protein
Submitted name:
Disintegrin and metalloproteinase domain-containing protein 28
Gene
ADAM28
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
Names & Taxonomyi
Protein namesi | Submitted name: Disintegrin and metalloproteinase domain-containing protein 28Imported |
Gene namesi | Name:ADAM28Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:206, ADAM28 |
VEuPathDBi | HostDB:ENSG00000042980.12 |
Subcellular locationi
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 295 – 319 | HelicalSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
MembranePTM / Processingi
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 98 ↔ 118 | PROSITE-ProRule annotation | ||
Disulfide bondi | 262 ↔ 272 | PROSITE-ProRule annotation | ||
Disulfide bondi | 280 ↔ 289 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondPROSITE-ProRule annotationARBA annotationProteomic databases
PeptideAtlasi | H0YBG8 |
PRIDEi | H0YBG8 |
ProteomicsDBi | 36717 |
Expressioni
Gene expression databases
Bgeei | ENSG00000042980, Expressed in caput epididymis and 196 other tissues |
ExpressionAtlasi | H0YBG8, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 40 – 126 | DisintegrinInterPro annotationAdd BLAST | 87 | |
Domaini | 258 – 290 | EGF-likeInterPro annotationAdd BLAST | 33 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 325 – 387 | DisorderedSequence analysisAdd BLAST | 63 |
Keywords - Domaini
EGF-like domainPROSITE-ProRule annotation, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000156716 |
HOGENOMi | CLU_716772_0_0_1 |
Family and domain databases
Gene3Di | 4.10.70.10, 1 hit |
InterProi | View protein in InterPro IPR006586, ADAM_Cys-rich IPR018358, Disintegrin_CS IPR001762, Disintegrin_dom IPR036436, Disintegrin_dom_sf IPR000742, EGF-like_dom |
Pfami | View protein in Pfam PF08516, ADAM_CR, 1 hit PF00200, Disintegrin, 1 hit |
PRINTSi | PR00289, DISINTEGRIN |
SMARTi | View protein in SMART SM00608, ACR, 1 hit SM00050, DISIN, 1 hit |
SUPFAMi | SSF57552, SSF57552, 1 hit |
PROSITEi | View protein in PROSITE PS00427, DISINTEGRIN_1, 1 hit PS50214, DISINTEGRIN_2, 1 hit PS01186, EGF_2, 1 hit PS50026, EGF_3, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
H0YBG8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
XFYIPTDFSS CSRLSYDKFF EDKLSNCLFN APLPTDIIST PICGNQLVEM
60 70 80 90 100
GEDCDCGTSE ECTNICCDAK TCKIKATFQC ALGECCEKCQ FKKAGMVCRP
110 120 130 140 150
AKDECDLPEM CNGKSGNCPD DRFQVNGFPC HHGKGHCLMG TCPTLQEQCT
160 170 180 190 200
ELWGPGTEVA DKSCYNRNEG GSKYGYCRRV DDTLIPCKAN DTMCGKLFCQ
210 220 230 240 250
GGSDNLPWKG RIVTFLTCKT FDPEDTSQEI GMVANGTKCG DNKVCINAEC
260 270 280 290 300
VDIEKAYKST NCSSKCKGHA VCDHELQCQC EEGWIPPDCD DSSVVFHFSI
310 320 330 340 350
VVGVLFPMAV IFVVVAMVIR HQSSREKQKK DQRPLSTTGT RPHKQKRKPQ
360 370 380
MVKAVQPQEM SQMKPHVYDL PVEGNEPPAS FDSNPKA
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9UKQ2 | ADA28_HUMAN | Disintegrin and metalloproteinase d... | ADAM28 ADAM23, MDCL | 775 | Annotation score: | ||
H0YBQ8 | H0YBQ8_HUMAN | Disintegrin and metalloproteinase d... | ADAM28 | 174 | Annotation score: | ||
E5RGY1 | E5RGY1_HUMAN | Disintegrin and metalloproteinase d... | ADAM28 | 217 | Annotation score: | ||
E5RJQ1 | E5RJQ1_HUMAN | Disintegrin and metalloproteinase d... | ADAM28 | 58 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC044891 Genomic DNA No translation available. AC120193 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000521629; ENSP00000429484; ENSG00000042980 |
UCSCi | uc064lgl.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC044891 Genomic DNA No translation available. AC120193 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | H0YBG8 |
PRIDEi | H0YBG8 |
ProteomicsDBi | 36717 |
Protocols and materials databases
Antibodypediai | 58742, 201 antibodies |
Genome annotation databases
Ensembli | ENST00000521629; ENSP00000429484; ENSG00000042980 |
UCSCi | uc064lgl.1, human |
Organism-specific databases
HGNCi | HGNC:206, ADAM28 |
OpenTargetsi | ENSG00000042980 |
VEuPathDBi | HostDB:ENSG00000042980.12 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000156716 |
HOGENOMi | CLU_716772_0_0_1 |
Miscellaneous databases
ChiTaRSi | ADAM28, human |
Gene expression databases
Bgeei | ENSG00000042980, Expressed in caput epididymis and 196 other tissues |
ExpressionAtlasi | H0YBG8, baseline and differential |
Family and domain databases
Gene3Di | 4.10.70.10, 1 hit |
InterProi | View protein in InterPro IPR006586, ADAM_Cys-rich IPR018358, Disintegrin_CS IPR001762, Disintegrin_dom IPR036436, Disintegrin_dom_sf IPR000742, EGF-like_dom |
Pfami | View protein in Pfam PF08516, ADAM_CR, 1 hit PF00200, Disintegrin, 1 hit |
PRINTSi | PR00289, DISINTEGRIN |
SMARTi | View protein in SMART SM00608, ACR, 1 hit SM00050, DISIN, 1 hit |
SUPFAMi | SSF57552, SSF57552, 1 hit |
PROSITEi | View protein in PROSITE PS00427, DISINTEGRIN_1, 1 hit PS50214, DISINTEGRIN_2, 1 hit PS01186, EGF_2, 1 hit PS50026, EGF_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H0YBG8_HUMAN | |
Accessioni | H0YBG8Primary (citable) accession number: H0YBG8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 22, 2012 |
Last sequence update: | February 22, 2012 | |
Last modified: | April 7, 2021 | |
This is version 67 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |