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UniProtKB - H0YB16 (H0YB16_HUMAN)
Protein
Submitted name:
Focal adhesion kinase 1
Gene
PTK2
Organism
Homo sapiens (Human)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 126 | ATPPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- protein tyrosine kinase activity Source: UniProtKB-KW
GO - Biological processi
- signal complex assembly Source: InterPro
Keywordsi
Molecular function | Kinase, Transferase, Tyrosine-protein kinaseARBA annotation |
Ligand | ATP-bindingPROSITE-ProRule annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Submitted name: Focal adhesion kinase 1 |
Gene namesi | Name:PTK2 |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9611, PTK2 |
VEuPathDBi | HostDB:ENSG00000169398 |
Subcellular locationi
Other locations
- focal adhesion Source: HPA
- intracellular membrane-bounded organelle Source: HPA
PTM / Processingi
Proteomic databases
MaxQBi | H0YB16 |
PeptideAtlasi | H0YB16 |
PRIDEi | H0YB16 |
ProteomicsDBi | 36567 |
Expressioni
Gene expression databases
Bgeei | ENSG00000169398, Expressed in corpus callosum and 241 other tissues |
ExpressionAtlasi | H0YB16, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 94 – 352 | Protein kinaseInterPro annotationAdd BLAST | 259 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 356 – 406 | DisorderedSequence analysisAdd BLAST | 51 | |
Regioni | 511 – 594 | DisorderedSequence analysisAdd BLAST | 84 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 481 – 501 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 538 – 552 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 562 – 594 | Polar residuesSequence analysisAdd BLAST | 33 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000155113 |
HOGENOMi | CLU_002646_2_0_1 |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR036137, Focal_adhe_kin_target_dom_sf IPR005189, Focal_adhesion_kin_target_dom IPR011009, Kinase-like_dom_sf IPR011993, PH-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF03623, Focal_AT, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00219, TyrKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit SSF68993, SSF68993, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 32 potential isoforms that are computationally mapped.Show allAlign All
H0YB16-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
IAENMADLID GYCRLVNGTS QSFIIRPQKE GERALPSIPK LANSEKQGMR
60 70 80 90 100
THAVSVSETD DYAEIIDEED TYTMPSKSYG IDEARDYEIQ RERIELGRCI
110 120 130 140 150
GEGQFGDVHQ GIYMSPENPA LAVAIKTCKN CTSDSVREKF LQEALTMRQF
160 170 180 190 200
DHPHIVKLIG VITENPVWII MELCTLGELR SFLQVRKYSL DLASLILYAY
210 220 230 240 250
QLSTALAYLE SKRFVHRDIA ARNVLVSSND CVKLGDFGLS RYMEDSTYYK
260 270 280 290 300
ASKGKLPIKW MAPESINFRR FTSASDVWMF GVCMWEILMH GVKPFQGVKN
310 320 330 340 350
NDVIGRIENG ERLPMPPNCP PTLYSLMTKC WAYDPSRRPR FTELKAQLST
360 370 380 390 400
ILEEEKAQQE ERMRMESRRQ ATVSWDSGGS DEAPPKPSRP GYPSPRSSEG
410 420 430 440 450
FYPSPQHMVQ TNHYQVSGYP GSHGITAMAG SIYPGQASLL DQTDSWNHRP
460 470 480 490 500
QEIAMWQPNV EDSTVLDLRG IGQVLPTHLM EERLIRQQQE MEEDQRWLEK
510 520 530 540 550
EERFLKPDVR LSRGSIDRED GSLQGPIGNQ HIYQPVGKPD PAAPPKKPPR
560 570 580 590 600
PGAPGHLGSL ASLSSPADSY NEGVKLQPQE ISPPPTANLD RSNDKVYENV
610 620 630 640 650
TGLVKAVIEM SSKIQPAPPE EYVPMVKEVG LALRTLLATV DETIPLLPAS
660 670 680 690 700
THREIEMAQK LLNSDLGELI NKMKLAQQYV MTSLQQEYKK QMLTAAHALA
710 720
VDAKNLLDVI DQARLKMLGQ TRPH
Computationally mapped potential isoform sequencesi
There are 32 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ05397 | FAK1_HUMAN | Focal adhesion kinase 1 | PTK2 FAK, FAK1 | 1,052 | Annotation score: | ||
H0YBP1 | H0YBP1_HUMAN | Non-specific protein-tyrosine kinas... | PTK2 | 1,017 | Annotation score: | ||
E7ESA6 | E7ESA6_HUMAN | Non-specific protein-tyrosine kinas... | PTK2 | 1,096 | Annotation score: | ||
H0YB99 | H0YB99_HUMAN | Non-specific protein-tyrosine kinas... | PTK2 | 319 | Annotation score: | ||
E9PEI4 | E9PEI4_HUMAN | Focal adhesion kinase 1 | PTK2 | 680 | Annotation score: | ||
H0YBZ1 | H0YBZ1_HUMAN | Focal adhesion kinase 1 | PTK2 | 753 | Annotation score: | ||
B4DWJ1 | B4DWJ1_HUMAN | Focal adhesion kinase 1 | PTK2 | 362 | Annotation score: | ||
E5RGA6 | E5RGA6_HUMAN | Focal adhesion kinase 1 | PTK2 | 156 | Annotation score: | ||
E5RJP0 | E5RJP0_HUMAN | Focal adhesion kinase 1 | PTK2 | 122 | Annotation score: | ||
E5RI29 | E5RI29_HUMAN | Focal adhesion kinase 1 | PTK2 | 124 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC067931 Genomic DNA No translation available. AC100860 Genomic DNA No translation available. AC105009 Genomic DNA No translation available. AC105235 Genomic DNA No translation available. KF458878 Genomic DNA No translation available. KF458882 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000523539.5; ENSP00000428492.1; ENSG00000169398.19 |
UCSCi | uc064qqr.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC067931 Genomic DNA No translation available. AC100860 Genomic DNA No translation available. AC105009 Genomic DNA No translation available. AC105235 Genomic DNA No translation available. KF458878 Genomic DNA No translation available. KF458882 Genomic DNA No translation available. |
3D structure databases
SMRi | H0YB16 |
ModBasei | Search... |
Proteomic databases
MaxQBi | H0YB16 |
PeptideAtlasi | H0YB16 |
PRIDEi | H0YB16 |
ProteomicsDBi | 36567 |
Protocols and materials databases
Antibodypediai | 725, 2885 antibodies from 48 providers |
Genome annotation databases
Ensembli | ENST00000523539.5; ENSP00000428492.1; ENSG00000169398.19 |
UCSCi | uc064qqr.1, human |
Organism-specific databases
HGNCi | HGNC:9611, PTK2 |
OpenTargetsi | ENSG00000169398 |
VEuPathDBi | HostDB:ENSG00000169398 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155113 |
HOGENOMi | CLU_002646_2_0_1 |
Miscellaneous databases
ChiTaRSi | PTK2, human |
Gene expression databases
Bgeei | ENSG00000169398, Expressed in corpus callosum and 241 other tissues |
ExpressionAtlasi | H0YB16, baseline and differential |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR036137, Focal_adhe_kin_target_dom_sf IPR005189, Focal_adhesion_kin_target_dom IPR011009, Kinase-like_dom_sf IPR011993, PH-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF03623, Focal_AT, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00219, TyrKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit SSF68993, SSF68993, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | H0YB16_HUMAN | |
Accessioni | H0YB16Primary (citable) accession number: H0YB16 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 22, 2012 |
Last sequence update: | February 22, 2012 | |
Last modified: | May 25, 2022 | |
This is version 77 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |