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Protein
Submitted name:

Rho guanine nucleotide exchange factor 10

Gene

ARHGEF10

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Rho guanine nucleotide exchange factor 10Imported
Gene namesi
Name:ARHGEF10Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000104728.15
HGNCiHGNC:14103 ARHGEF10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000104728

PTM / Processingi

Proteomic databases

EPDiH0YAN8
MaxQBiH0YAN8
PRIDEiH0YAN8

Expressioni

Gene expression databases

BgeeiENSG00000104728 Expressed in 227 organ(s), highest expression level in tibial nerve
ExpressionAtlasiH0YAN8 baseline and differential

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 256DHInterPro annotationAdd BLAST188

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili239 – 270Sequence analysisAdd BLAST32

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG3522 Eukaryota
ENOG410ZJK1 LUCA
GeneTreeiENSGT00670000097546

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR030632 ARHGEF10
IPR039919 ARHGEF10/ARHGEF17
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR12877 PTHR12877, 2 hits
PTHR12877:SF14 PTHR12877:SF14, 2 hits
PfamiView protein in Pfam
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

H0YAN8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
AKDGTKDGLE RTRAAVKRGR SFIRTKSLIA QDHRSSLEEE QNLFIDVDCK
60 70 80 90 100
HPEAILTPMP EGLSQQQVVR RYILGSVVDS EKNYVDALKR ILEQYEKPLS
110 120 130 140 150
EMEPKVLSER KLKTVFYRVK EILQCHSLFQ IALASRVSEW DSVEMIGDVF
160 170 180 190 200
VASFSKSMVL DAYSEYVNNF STAVAVLKKT CATKPAFLEF LKQEQEASPD
210 220 230 240 250
RTTLYSLMMK PIQRFPQFIL LLQDMLKNTS KGHPDRLPLQ MALTELETLA
260 270 280 290 300
EKLNERKRDA DQRCEVKQIA KAINERYLNK LLSSGSRYLI RSDDMIETVY
310 320 330 340 350
NDRGEIVKTK ERRVFMLNDV LMCATVSSRP SHDSRVMSSQ RYLLKWSVPL
360 370 380 390 400
GHVDAIEYGS SAGTGEHSRH LAVHPPESLA VVANAKPNKV YMGPGQLYQD
410 420 430 440 450
LQNLLHDLNV IGQITQLIGN LKGNYQNLNQ SVAHDWTSGL QRLILKKEDE
460 470 480 490 500
IRAADCCRIQ LQLPGKQDKS GRPTFFTAVF NTFTPAIKES WVNSLQMAKL
510 520 530 540 550
ALEEENHMGW FCVEDDGNHI KKEKHPLLVG HMPVMVAKQQ EFKIGSCTHQ
560 570 580 590 600
MGQIAIVSFQ NSTPKVIECF NVESRILCML YVPVEEKRRE PGAPPDPETP
610 620 630 640 650
AVRASDVPTI CVGTEEGSIS IYKSSQGSKK VRLQHFFTPE KSTVMSLACT
660 670 680 690 700
SQSLYAGLVN GAVASYARAP DGSWDSEPQK VIKLGVLPVR SLLMMEDTLW
710 720 730 740 750
AASGGQVFII SVETHAVEGQ LEAHQEEGMV ISHMAVSGVG IWIAFTSGST
760 770 780 790 800
LRLFHTETLK HLQDINIATP VHNMLPGHQR LSVTSLLVCH GLLMVGTSLG
810 820 830 840 850
VLVALPVPRL QGIPKVTGRG MVSYHAHNSP VKFIVLATAL HEKDKDKSRD
860 870 880 890 900
SLAPGPEPQD EDQKDALPSG GAGSSLSQGD PDAAIWLGDS LGSMTQKSDL
910 920 930 940 950
SSSSGSLSLS HGSSSLEHRS EDSTIYDLLK DPVSLRSKAR RAKKAKASSA
960 970 980
LVVCGGQGHR RVHRKARQPH QEELAPTVMV WQIPLLNI
Length:988
Mass (Da):109,653
Last modified:February 22, 2012 - v1
Checksum:i2DF412EC6A8A4938
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O15013ARHGA_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF10 KIAA0294
1,369Annotation score:
E9PB39E9PB39_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF10
380Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC019257 Genomic DNA No translation available.
KF458656 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000522435; ENSP00000427768; ENSG00000104728
ENST00000634038; ENSP00000488344; ENSG00000274726
UCSCiuc064jye.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC019257 Genomic DNA No translation available.
KF458656 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiH0YAN8
MaxQBiH0YAN8
PRIDEiH0YAN8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000522435; ENSP00000427768; ENSG00000104728
ENST00000634038; ENSP00000488344; ENSG00000274726
UCSCiuc064jye.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000104728.15
HGNCiHGNC:14103 ARHGEF10
OpenTargetsiENSG00000104728
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3522 Eukaryota
ENOG410ZJK1 LUCA
GeneTreeiENSGT00670000097546

Miscellaneous databases

ChiTaRSiARHGEF10 human

Gene expression databases

BgeeiENSG00000104728 Expressed in 227 organ(s), highest expression level in tibial nerve
ExpressionAtlasiH0YAN8 baseline and differential

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR030632 ARHGEF10
IPR039919 ARHGEF10/ARHGEF17
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR12877 PTHR12877, 2 hits
PTHR12877:SF14 PTHR12877:SF14, 2 hits
PfamiView protein in Pfam
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH0YAN8_HUMAN
AccessioniPrimary (citable) accession number: H0YAN8
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: November 7, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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