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Protein
Submitted name:

Receptor of-activated protein C kinase 1

Gene

RACK1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

SignaLinkiH0YAM7

Names & Taxonomyi

Protein namesi
Submitted name:
Receptor of-activated protein C kinase 1Imported
Gene namesi
Name:RACK1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000204628.11
HGNCiHGNC:4399 RACK1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204628

PTM / Processingi

Proteomic databases

MaxQBiH0YAM7
PeptideAtlasiH0YAM7
PRIDEiH0YAM7

Expressioni

Gene expression databases

BgeeiENSG00000204628 Expressed in 246 organ(s), highest expression level in female gonad
ExpressionAtlasiH0YAM7 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH0YAM7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 136WD_REPEATS_REGIONInterPro annotationAdd BLAST129
Repeati8 – 40WDPROSITE-ProRule annotationAdd BLAST33
Repeati51 – 94WDPROSITE-ProRule annotationAdd BLAST44
Repeati95 – 136WDPROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

WD repeatPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0279 Eukaryota
ENOG410XQGZ LUCA
GeneTreeiENSGT00910000144232

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 4 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 3 hits
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 21 potential isoforms that are computationally mapped.iShow all

H0YAM7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XGTTTRRFVG HTKDVLSVAF SSDNRQIVSG SRDKTIKLWN TLGVCKYTVQ
60 70 80 90 100
DESHSEWVSC VRFSPNSSNP IIVSCGWDKL VKVWNLANCK LKTNHIGHTG
110 120 130 140 150
YLNTVTVSPD GSLCASGGKD GQAMLWDLNE GKHLYTLDGG DIINALCFSP
160 170 180 190 200
NRYWLCAATG PSIKIWDLEG KIIVDELKQE VISTSSKAEP PQCTSLAWSA
210 220 230 240
DGQEYITTTY KLAVEMRAVS YSLPGVVAHA YWRLRWEDLL NCRGLRL
Length:247
Mass (Da):27,416
Last modified:February 22, 2012 - v1
Checksum:iC5D8B49C4318DEAF
GO

Computationally mapped potential isoform sequencesi

There are 21 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P63244RACK1_HUMAN
Receptor of activated protein C kin...
RACK1 GNB2L1, HLC7, PIG21
317Annotation score:
D6RFX4D6RFX4_HUMAN
Receptor of-activated protein C kin...
RACK1
194Annotation score:
D6REE5D6REE5_HUMAN
Receptor of-activated protein C kin...
RACK1
321Annotation score:
D6R9L0D6R9L0_HUMAN
Receptor of-activated protein C kin...
RACK1
300Annotation score:
D6RAC2D6RAC2_HUMAN
Receptor of-activated protein C kin...
RACK1
269Annotation score:
D6R9Z1D6R9Z1_HUMAN
Receptor of-activated protein C kin...
RACK1
236Annotation score:
H0Y8W2H0Y8W2_HUMAN
Receptor of-activated protein C kin...
RACK1
274Annotation score:
J3KPE3J3KPE3_HUMAN
Receptor of-activated protein C kin...
RACK1
273Annotation score:
H0Y8R5H0Y8R5_HUMAN
Receptor of-activated protein C kin...
RACK1
138Annotation score:
D6RHH4D6RHH4_HUMAN
Receptor of-activated protein C kin...
RACK1
233Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008443 Genomic DNA No translation available.
KC877161 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000504128; ENSP00000427677; ENSG00000204628
UCSCiuc063kxh.1 human

Similar proteinsi

Entry informationi

Entry nameiH0YAM7_HUMAN
AccessioniPrimary (citable) accession number: H0YAM7
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: September 12, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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