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Protein
Submitted name:

Transmembrane protease serine 11A

Gene

TMPRSS11A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei194Charge relay systemUniRule annotation1
Active sitei239Charge relay systemUniRule annotation1
Active sitei335Charge relay systemUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Transmembrane protease serine 11AImported
Gene namesi
Name:TMPRSS11AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000187054.14
HGNCiHGNC:27954 TMPRSS11A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 38HelicalSequence analysisAdd BLAST27

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000187054

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PeptideAtlasiH0YAL9
PRIDEiH0YAL9

Expressioni

Gene expression databases

BgeeiENSG00000187054 Expressed in 31 organ(s), highest expression level in ectocervix
ExpressionAtlasiH0YAL9 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH0YAL9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 144SEAInterPro annotationAdd BLAST120
Domaini154 – 384Peptidase S1InterPro annotationAdd BLAST231

Sequence similaritiesi

Belongs to the peptidase S1 family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

GeneTreeiENSGT00920000148977

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
Gene3Di3.30.70.960, 1 hit
InterProiView protein in InterPro
IPR017329 Pept_S1A_HAT/DESC1
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR000082 SEA_dom
IPR036364 SEA_dom_sf
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF01390 SEA, 1 hit
PF00089 Trypsin, 1 hit
PIRSFiPIRSF037941 TMPRSS11ABCDE, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
SSF82671 SSF82671, 1 hit
PROSITEiView protein in PROSITE
PS50024 SEA, 1 hit
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

H0YAL9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
GFGTRSRNLK PWMIAVLIVL SLTVVAVTIG LLVHFLVFDP QINNNFGQSN
60 70 80 90 100
TYQLKDLRET TENLVDEIFI DSAWKKNYIK NQVVRLTPEE DGVKVDVIMV
110 120 130 140 150
FQFPSTEQRA VREKKIQSIL NQKIRNLRAL PINASSVQVN GCGKRVVPLN
160 170 180 190 200
VNRIASGVIA PKAAWPWQAS LQYDNIHQCG ATLISNTWLV TAAHCFQKYK
210 220 230 240 250
NPHQWTVSFG TKINPPLMKR NVRRFIIHEK YRSAAREYDI AVVQVSSRVT
260 270 280 290 300
FSDDIRQICL PEASASFQPN LTVHITGFGA LYYGGESQND LREARVKIIS
310 320 330 340 350
DDVCKQPQVY GNDIKPGMFC AGYMEGIYDA CRGDSGGPLV TRDLKDTWYL
360 370 380
IGIVSWGDNC GQKDKPGVYT QVTYYRNWIA SKTGI
Length:385
Mass (Da):43,413
Last modified:February 22, 2012 - v1
Checksum:i3616E2436016341D
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6ZMR5TM11A_HUMAN
Transmembrane protease serine 11A
TMPRSS11A ECRG1, HATL1, HESP
421Annotation score:
A0A0A0MR82A0A0A0MR82_HUMAN
Transmembrane protease serine
TMPRSS11A
421Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC096653 Genomic DNA No translation available.
AC096727 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000513536; ENSP00000427621; ENSG00000187054
UCSCiuc062xac.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC096653 Genomic DNA No translation available.
AC096727 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH0YAL9
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiH0YAL9
PRIDEiH0YAL9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000513536; ENSP00000427621; ENSG00000187054
UCSCiuc062xac.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000187054.14
HGNCiHGNC:27954 TMPRSS11A
OpenTargetsiENSG00000187054
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00920000148977

Miscellaneous databases

ChiTaRSiTMPRSS11A human

Gene expression databases

BgeeiENSG00000187054 Expressed in 31 organ(s), highest expression level in ectocervix
ExpressionAtlasiH0YAL9 baseline and differential

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
Gene3Di3.30.70.960, 1 hit
InterProiView protein in InterPro
IPR017329 Pept_S1A_HAT/DESC1
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR000082 SEA_dom
IPR036364 SEA_dom_sf
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF01390 SEA, 1 hit
PF00089 Trypsin, 1 hit
PIRSFiPIRSF037941 TMPRSS11ABCDE, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
SSF82671 SSF82671, 1 hit
PROSITEiView protein in PROSITE
PS50024 SEA, 1 hit
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH0YAL9_HUMAN
AccessioniPrimary (citable) accession number: H0YAL9
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: September 12, 2018
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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