Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Slit homolog 2 protein

Gene

SLIT2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Slit homolog 2 proteinImported
Gene namesi
Name:SLIT2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000145147.19
HGNCiHGNC:11086 SLIT2

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000145147

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi76 ↔ 85PROSITE-ProRule annotation
Disulfide bondi117 ↔ 126PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

MaxQBiH0Y9Z6
PeptideAtlasiH0Y9Z6
PRIDEiH0Y9Z6

Expressioni

Gene expression databases

BgeeiENSG00000145147 Expressed in 230 organ(s), highest expression level in upper lobe of lung
ExpressionAtlasiH0Y9Z6 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH0Y9Z6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 86EGF-likeInterPro annotationAdd BLAST36
Domaini88 – 127EGF-likeInterPro annotationAdd BLAST40
Domaini129 – 165EGF-likeInterPro annotationAdd BLAST37

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG4237 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00930000150809

Family and domain databases

InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
PfamiView protein in Pfam
PF00008 EGF, 3 hits
PF01463 LRRCT, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 3 hits
SM00179 EGF_CA, 3 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 3 hits
PS01187 EGF_CA, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

H0Y9Z6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XSDWVKSEYK EPGIARCAGP GEMADKLLLT TPSKKFTCQG PVDVNILAKC
60 70 80 90 100
NPCLSNPCKN DGTCNSDPVD FYRCTCPYGF KGQDCDVPIH ACISNPCKHG
110 120 130 140 150
GTCHLKEGEE DGFWCICADG FEGENCEVNV DDCEDNDCEN NSTCVDGINN
160 170 180 190
YTCLCPPEYT GTNNRKYFAF HQYICLKASL ELCYICLVNL FLFDKW
Length:196
Mass (Da):21,801
Last modified:February 22, 2012 - v1
Checksum:iC164C9805BF1E704
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O94813SLIT2_HUMAN
Slit homolog 2 protein
SLIT2 SLIL3
1,529Annotation score:
X6R3P0X6R3P0_HUMAN
Slit homolog 2 protein
SLIT2
1,542Annotation score:
A0A087WYV5A0A087WYV5_HUMAN
Slit homolog 2 protein
SLIT2
1,439Annotation score:
F5H0U4F5H0U4_HUMAN
Slit homolog 2 protein
SLIT2
212Annotation score:
H0Y968H0Y968_HUMAN
Slit homolog 2 protein
SLIT2
82Annotation score:
E9PCX4E9PCX4_HUMAN
Slit homolog 2 protein
SLIT2
146Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC021118 Genomic DNA No translation available.
AC092577 Genomic DNA No translation available.
AC096718 Genomic DNA No translation available.
AC108011 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000509941; ENSP00000425609; ENSG00000145147
UCSCiuc062vmr.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC021118 Genomic DNA No translation available.
AC092577 Genomic DNA No translation available.
AC096718 Genomic DNA No translation available.
AC108011 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH0Y9Z6
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiH0Y9Z6
PeptideAtlasiH0Y9Z6
PRIDEiH0Y9Z6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000509941; ENSP00000425609; ENSG00000145147
UCSCiuc062vmr.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000145147.19
HGNCiHGNC:11086 SLIT2
OpenTargetsiENSG00000145147
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4237 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00930000150809

Miscellaneous databases

ChiTaRSiSLIT2 human

Gene expression databases

BgeeiENSG00000145147 Expressed in 230 organ(s), highest expression level in upper lobe of lung
ExpressionAtlasiH0Y9Z6 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
PfamiView protein in Pfam
PF00008 EGF, 3 hits
PF01463 LRRCT, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 3 hits
SM00179 EGF_CA, 3 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 3 hits
PS01187 EGF_CA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH0Y9Z6_HUMAN
AccessioniPrimary (citable) accession number: H0Y9Z6
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: November 7, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again