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Protein
Submitted name:

Protein furry homolog-like

Gene

FRYL

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Protein furry homolog-likeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FRYLImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000075539.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29127 FRYL

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000075539

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
H0Y9X0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
H0Y9X0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
H0Y9X0

PeptideAtlas

More...
PeptideAtlasi
H0Y9X0

PRoteomics IDEntifications database

More...
PRIDEi
H0Y9X0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000075539 Expressed in 230 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
H0Y9X0 baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
H0Y9X0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini38 – 193MOR2-PAG1_midInterPro annotationAdd BLAST156
Domaini235 – 281MOR2-PAG1_midInterPro annotationAdd BLAST47
Domaini464 – 523MOR2-PAG1_midInterPro annotationAdd BLAST60
Domaini608 – 729MOR2-PAG1_midInterPro annotationAdd BLAST122
Domaini871 – 1123MOR2-PAG1_CInterPro annotationAdd BLAST253

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1825 Eukaryota
ENOG410XSZS LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00610000086058

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR025481 Cell_Morphogen_C
IPR039867 Furry/Tao3/Mor2
IPR029473 MOR2-PAG1_mid

The PANTHER Classification System

More...
PANTHERi
PTHR12295 PTHR12295, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14225 MOR2-PAG1_C, 1 hit
PF14228 MOR2-PAG1_mid, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

H0Y9X0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XGYLYKWLDN ILDSLDKKVH QLGCEAVTLL LELNPDQSNL MYWAVDRCYT
60 70 80 90 100
GSGRVAAGCF KAIANVFQNR DYQCDTVMLL NLILFKAADS SRSIYEVAMQ
110 120 130 140 150
LLQILEPKMF RYAHKLEVQR TDGVLSQLSP LPHLYSVSYY QLSEELARAY
160 170 180 190 200
PELTLAIFSE ISQRIQTAHP AGRQVMLHYL LPWMNNIELV DLKPLPTARR
210 220 230 240 250
HDEDEDDSLK DRELMVTSRR WLRGEGWGSP QATAMVLNNL MYMTAKYGDE
260 270 280 290 300
LAWSEVENVW TTLADGWPKN LKIILHFLIS ICGVNSEPSL LPYVKKVIVY
310 320 330 340 350
LGRDKTMQLL EELVSELQLT DPVSSGVTHM DNPPYYRITS SYKIPSVTSG
360 370 380 390 400
TTSSSNTMVA PTDGNPDNKP IKENIEESYV HLDIYSGLNS HLNRQHHRLE
410 420 430 440 450
SRYSSSSGGS YEEEKSDSMP LYSNWRLKVM EHNQGEPLPF PPAGGCWSPL
460 470 480 490 500
VDYVPETSSP GLPLHRCNIA VILLTDLIID HSVKVEWGSY LHLLLHAIFI
510 520 530 540 550
GFDHCHPEVY EHCKRLLLHL LIVMGPNSNI RTVASVLLRN KEFNEPRVLT
560 570 580 590 600
VKQVAHLDYN FTGINDFIPD YQPSPMTDSG LSSSSTSSSI SLGNNSAAIS
610 620 630 640 650
HLHTTILNEV DISVEQDGKV KTLMEFITSR KRGPLWNHED VSAKNPSIKS
660 670 680 690 700
AEQLTTFLKH VVSVFKQSSS EGIHLEHHLS EVALQTALSC SSRHYAGRSF
710 720 730 740 750
QIFRALKQPL TATTLSDVLS RLVETVGDPG EDAQGFVIEL LLTLESAIDT
760 770 780 790 800
LAETMKHYDL LSALSQTSYH DPIMGNKYAA NRKSTGQLNL STSPINSSSY
810 820 830 840 850
LGYNSNARSN SLRLSLIGDR RGDRRRSNTL DIMDGRINHS SSLARTRSLS
860 870 880 890 900
SLREKGMYDV QSTTEPTNLM ATIFWIAASL LESDYEYEYL LALRLLNKLL
910 920 930 940 950
IHLPLDKSES REKIENVQSK LKWTNFPGLQ QLFLKGFTSA STQEMTVHLL
960 970 980 990 1000
SKLISVSKHT LVDPSQLSGF PLNILCLLPH LIQHFDSPTQ FCKETASRIA
1010 1020 1030 1040 1050
KVCAEEKCPT LVNLAHMMSL YSTHTYSRDC SNWINVVCRY LHDSFSDTTF
1060 1070 1080 1090 1100
NLVTYLAELL EKGLSSMQQS LLQIIYSLLS HIDLSAAPAK QFNLEIIKII
1110 1120 1130 1140 1150
GKYVQSPYWK EALNILKLVV SRSASLVVPS DIPKTYGGDT GSPEISFTKI
1160 1170 1180 1190 1200
FNNVSKELPG KTLDFHFDIS ETPIIGNKYG DQHSAAGRNG KPKVIAVTRS
1210 1220 1230 1240 1250
TSSTSSGSNS NALVPVSWKR PQLSQRRTRE KLMNVLSLCG PESGLPKNPS
1260 1270 1280 1290 1300
VVFSSNEDLE VGDQQTSLIS TTEDINQEEE VAVEDNSSEQ QFGVFKDFDF
1310 1320 1330 1340 1350
LDVELEDAEG ESMDNFNWGV RRRSLDSIDK GDTPSLQEYQ CSSSTPSLNL
1360 1370 1380 1390 1400
TNQEDTDESS EEEAALTASQ ILSRTQMLNS DSATDETIPD HPDLLLQSED
1410 1420 1430 1440 1450
STGSITTEEV LQIRDETPTL EASLDNANSR LPEDTTSVLK EEHVTTFEDE

GSYII
Length:1,455
Mass (Da):162,911
Last modified:February 22, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9322C6A8FB2C2770
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O94915FRYL_HUMAN
Protein furry homolog-like
FRYL AF4P12, KIAA0826
3,013Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z2S2F2Z2S2_HUMAN
Protein furry homolog-like
FRYL
1,553Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2C9F2R7A0A2C9F2R7_HUMAN
Protein furry homolog-like
FRYL
1,716Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YEZ9A0A286YEZ9_HUMAN
Protein furry homolog-like
FRYL
1,563Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RJI4D6RJI4_HUMAN
Protein furry homolog-like
FRYL
471Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9B9D6R9B9_HUMAN
Protein furry homolog-like
FRYL
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1
Non-terminal residuei1455Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC068037 Genomic DNA No translation available.
AC096952 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000514617; ENSP00000425344; ENSG00000075539

UCSC genome browser

More...
UCSCi
uc062wlf.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC068037 Genomic DNA No translation available.
AC096952 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH0Y9X0
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiH0Y9X0
jPOSTiH0Y9X0
MaxQBiH0Y9X0
PeptideAtlasiH0Y9X0
PRIDEiH0Y9X0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000514617; ENSP00000425344; ENSG00000075539
UCSCiuc062wlf.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000075539.13
HGNCiHGNC:29127 FRYL
OpenTargetsiENSG00000075539

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1825 Eukaryota
ENOG410XSZS LUCA
GeneTreeiENSGT00610000086058

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FRYL human

Gene expression databases

BgeeiENSG00000075539 Expressed in 230 organ(s), highest expression level in corpus callosum
ExpressionAtlasiH0Y9X0 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR025481 Cell_Morphogen_C
IPR039867 Furry/Tao3/Mor2
IPR029473 MOR2-PAG1_mid
PANTHERiPTHR12295 PTHR12295, 1 hit
PfamiView protein in Pfam
PF14225 MOR2-PAG1_C, 1 hit
PF14228 MOR2-PAG1_mid, 4 hits
SUPFAMiSSF48371 SSF48371, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH0Y9X0_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H0Y9X0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: January 16, 2019
This is version 49 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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