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Protein
Submitted name:

Interferon regulatory factor 2

Gene

IRF2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Interferon regulatory factor 2Imported
Gene namesi
Name:IRF2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000168310.10
HGNCiHGNC:6117 IRF2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000168310

PTM / Processingi

Proteomic databases

PeptideAtlasiH0Y956
PRIDEiH0Y956

Expressioni

Gene expression databases

BgeeiENSG00000168310 Expressed in 201 organ(s), highest expression level in leukocyte
ExpressionAtlasiH0Y956 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH0Y956
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 25IRF tryptophan pentad repeatInterPro annotationAdd BLAST25

Phylogenomic databases

GeneTreeiENSGT00760000119093

Family and domain databases

InterProiView protein in InterPro
IPR001346 Interferon_reg_fact_DNA-bd_dom
IPR031218 IRF2
PANTHERiPTHR11949 PTHR11949, 2 hits
PTHR11949:SF22 PTHR11949:SF22, 2 hits
PROSITEiView protein in PROSITE
PS51507 IRF_2, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

H0Y956-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
PDIEEVKDKS IKKGNNAFRV YRMLPLSERP SKKVVGQSHL DSNIENQEIV
60 70 80 90 100
TNPPDICQVV EVTTESDEQP VSMSELYPLQ ISPVSSYAES ETTDSVPSDE
110
ESAEGRPHWR KRN
Length:113
Mass (Da):12,756
Last modified:February 22, 2012 - v1
Checksum:i2E52CC64293676AB
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P14316IRF2_HUMAN
Interferon regulatory factor 2
IRF2
349Annotation score:
K4DIA5K4DIA5_HUMAN
Interferon regulatory factor 2
IRF2
176Annotation score:
D6R9N5D6R9N5_HUMAN
Interferon regulatory factor 2
IRF2
137Annotation score:
D6RB08D6RB08_HUMAN
Interferon regulatory factor 2
IRF2
160Annotation score:
D6RED1D6RED1_HUMAN
Interferon regulatory factor 2
IRF2
83Annotation score:
K4DIA4K4DIA4_HUMAN
Interferon regulatory factor 2
IRF2
196Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei113Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC099343 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000502750; ENSP00000423074; ENSG00000168310
UCSCiuc063bho.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC099343 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH0Y956
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiH0Y956
PRIDEiH0Y956

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000502750; ENSP00000423074; ENSG00000168310
UCSCiuc063bho.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000168310.10
HGNCiHGNC:6117 IRF2
OpenTargetsiENSG00000168310
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000119093

Miscellaneous databases

ChiTaRSiIRF2 human

Gene expression databases

BgeeiENSG00000168310 Expressed in 201 organ(s), highest expression level in leukocyte
ExpressionAtlasiH0Y956 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR001346 Interferon_reg_fact_DNA-bd_dom
IPR031218 IRF2
PANTHERiPTHR11949 PTHR11949, 2 hits
PTHR11949:SF22 PTHR11949:SF22, 2 hits
PROSITEiView protein in PROSITE
PS51507 IRF_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH0Y956_HUMAN
AccessioniPrimary (citable) accession number: H0Y956
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: November 7, 2018
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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