UniProtKB - H0Y8W7 (H0Y8W7_HUMAN)
Protein
Submitted name:
C-terminal-binding protein 1
Gene
CTBP1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- NAD binding Source: InterPro
- oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: InterPro
Keywordsi
Molecular function | OxidoreductaseUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: C-terminal-binding protein 1Imported |
Gene namesi | Name:CTBP1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000159692.15 |
HGNCi | HGNC:2494, CTBP1 |
Subcellular locationi
Nucleus
- nucleoplasm Source: HPA
PTM / Processingi
Proteomic databases
MaxQBi | H0Y8W7 |
PeptideAtlasi | H0Y8W7 |
PRIDEi | H0Y8W7 |
ProteomicsDBi | 35830 |
Expressioni
Gene expression databases
Bgeei | ENSG00000159692, Expressed in oviduct epithelium and 254 other tissues |
ExpressionAtlasi | H0Y8W7, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 199 | 2-Hacid_dhInterPro annotationAdd BLAST | 198 | |
Domaini | 29 – 164 | 2-Hacid_dh_CInterPro annotationAdd BLAST | 136 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 253 – 287 | DisorderedSequence analysisAdd BLAST | 35 |
Sequence similaritiesi
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.UniRule annotation
Phylogenomic databases
GeneTreei | ENSGT00940000157061 |
HOGENOMi | CLU_974981_0_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR006139, D-isomer_2_OHA_DH_cat_dom IPR029753, D-isomer_DH_CS IPR006140, D-isomer_DH_NAD-bd IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF00389, 2-Hacid_dh, 1 hit PF02826, 2-Hacid_dh_C, 1 hit |
SUPFAMi | SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00671, D_2_HYDROXYACID_DH_3, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All
H0Y8W7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
XLEKFKALRI IVRIGSGFDN IDIKSAGDLG RVGQAVALRA KAFGFNVLFY
60 70 80 90 100
DPYLSDGVER ALGLQRVSTL QDLLFHSDCV TLHCGLNEHN HHLINDFTVK
110 120 130 140 150
QMRQGAFLVN TARGGLVDEK ALAQALKEGR IRGAALDVHE SEPFSFSQGP
160 170 180 190 200
LKDAPNLICT PHAAWYSEQA SIEMREEAAR EIRRAITGRI PDSLKNCVNK
210 220 230 240 250
DHLTAATHWA SMDPAVVHPE LNGAAYRYPP GVVGVAPTGI PAAVEGIVPS
260 270 280
AMSLSHGLPP VAHPPHAPSP GQTVKPEADR DHASDQL
Computationally mapped potential isoform sequencesi
There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ13363 | CTBP1_HUMAN | C-terminal-binding protein 1 | CTBP1 CTBP | 440 | Annotation score: | ||
H0Y8U5 | H0Y8U5_HUMAN | C-terminal-binding protein 1 | CTBP1 | 184 | Annotation score: | ||
D6RAX2 | D6RAX2_HUMAN | C-terminal-binding protein 1 | CTBP1 | 186 | Annotation score: | ||
E7ESU7 | E7ESU7_HUMAN | C-terminal-binding protein 1 | CTBP1 | 171 | Annotation score: | ||
H0Y9M9 | H0Y9M9_HUMAN | C-terminal-binding protein 1 | CTBP1 | 145 | Annotation score: | ||
E7EPF8 | E7EPF8_HUMAN | C-terminal-binding protein 1 | CTBP1 | 202 | Annotation score: | ||
E9PGB1 | E9PGB1_HUMAN | C-terminal-binding protein 1 | CTBP1 | 145 | Annotation score: | ||
E7EUB3 | E7EUB3_HUMAN | C-terminal-binding protein 1 | CTBP1 | 168 | Annotation score: | ||
H0Y913 | H0Y913_HUMAN | C-terminal-binding protein 1 | CTBP1 | 24 | Annotation score: | ||
A0A0D9SGE6 | A0A0D9SGE6_HUMAN | C-terminal-binding protein 1 | CTBP1 | 69 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC092535 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000504092; ENSP00000422364; ENSG00000159692 |
UCSCi | uc062ujy.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC092535 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
Proteomic databases
MaxQBi | H0Y8W7 |
PeptideAtlasi | H0Y8W7 |
PRIDEi | H0Y8W7 |
ProteomicsDBi | 35830 |
Protocols and materials databases
Antibodypediai | 3783, 652 antibodies |
Genome annotation databases
Ensembli | ENST00000504092; ENSP00000422364; ENSG00000159692 |
UCSCi | uc062ujy.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000159692.15 |
HGNCi | HGNC:2494, CTBP1 |
OpenTargetsi | ENSG00000159692 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000157061 |
HOGENOMi | CLU_974981_0_0_1 |
Miscellaneous databases
ChiTaRSi | CTBP1, human |
Gene expression databases
Bgeei | ENSG00000159692, Expressed in oviduct epithelium and 254 other tissues |
ExpressionAtlasi | H0Y8W7, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR006139, D-isomer_2_OHA_DH_cat_dom IPR029753, D-isomer_DH_CS IPR006140, D-isomer_DH_NAD-bd IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF00389, 2-Hacid_dh, 1 hit PF02826, 2-Hacid_dh_C, 1 hit |
SUPFAMi | SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00671, D_2_HYDROXYACID_DH_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H0Y8W7_HUMAN | |
Accessioni | H0Y8W7Primary (citable) accession number: H0Y8W7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 22, 2012 |
Last sequence update: | February 22, 2012 | |
Last modified: | December 2, 2020 | |
This is version 51 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |