UniProtKB - H0Y8Q6 (H0Y8Q6_HUMAN)
Protein
Submitted name:
Canalicular multispecific organic anion transporter 2
Gene
ABCC3
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- ATPase-coupled transmembrane transporter activity Source: InterPro
- ATP binding Source: InterPro
Keywordsi
Biological process | TransportARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Canalicular multispecific organic anion transporter 2Imported |
Gene namesi | Name:ABCC3Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:54, ABCC3 |
VEuPathDBi | HostDB:ENSG00000108846.15 |
Subcellular locationi
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 114 – 141 | HelicalSequence analysisAdd BLAST | 28 | |
Transmembranei | 161 – 184 | HelicalSequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
MembranePTM / Processingi
Proteomic databases
MaxQBi | H0Y8Q6 |
PeptideAtlasi | H0Y8Q6 |
PRIDEi | H0Y8Q6 |
ProteomicsDBi | 35772 |
Expressioni
Gene expression databases
Bgeei | ENSG00000108846, Expressed in left adrenal gland and 180 other tissues |
ExpressionAtlasi | H0Y8Q6, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 121 – 230 | ABC transmembrane type-1InterPro annotationAdd BLAST | 110 | |
Domaini | 231 – 299 | ABC transmembrane type-1InterPro annotationAdd BLAST | 69 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 58 – 80 | DisorderedSequence analysisAdd BLAST | 23 |
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000161624 |
HOGENOMi | CLU_932359_0_0_1 |
Family and domain databases
Gene3Di | 1.20.1560.10, 2 hits |
InterProi | View protein in InterPro IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf |
Pfami | View protein in Pfam PF00664, ABC_membrane, 2 hits |
SUPFAMi | SSF90123, SSF90123, 1 hit |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 2 hits |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
H0Y8Q6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
XAPDEDQGHL EDSWTALEGA EDKEALLIED TLSNHTDLTD NDPVTYVVQK
60 70 80 90 100
QFMRQLSALS SDGEGQGRPV PRRHLGPSEK VQVTEAKADG ALTQEEKAAI
110 120 130 140 150
GTVELSVFWD YAKAVGLCTT LAICLLYVGQ SAAAIGANVW LSAWTNDAMA
160 170 180 190 200
DSRQNNTSLR LGVYAALGIL QGFLVMLAAM AMAAGGIQAA RVLHQALLHN
210 220 230 240 250
KIRSPQSFFD TTPSGRILNC FSKDIYVVDE RFYAATSRQL KRLESVSRSP
260 270 280 290 300
IYSHFSETVT GASVIRAYNR SRDFEIISDT KVDANQRSCY PYIISNRWLS
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO15438 | MRP3_HUMAN | ATP-binding cassette sub-family C m... | ABCC3 CMOAT2, MLP2, MRP3 | 1,527 | Annotation score: | ||
D6RJE5 | D6RJE5_HUMAN | Canalicular multispecific organic a... | ABCC3 | 43 | Annotation score: | ||
D6RAB7 | D6RAB7_HUMAN | Canalicular multispecific organic a... | ABCC3 | 76 | Annotation score: | ||
H0Y9T4 | H0Y9T4_HUMAN | Canalicular multispecific organic a... | ABCC3 | 43 | Annotation score: | ||
H0Y8T5 | H0Y8T5_HUMAN | Canalicular multispecific organic a... | ABCC3 | 56 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 | |
Non-terminal residuei | 300 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004590 Genomic DNA No translation available. AC005921 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000513745; ENSP00000421755; ENSG00000108846 |
UCSCi | uc060hlv.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004590 Genomic DNA No translation available. AC005921 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
Proteomic databases
MaxQBi | H0Y8Q6 |
PeptideAtlasi | H0Y8Q6 |
PRIDEi | H0Y8Q6 |
ProteomicsDBi | 35772 |
Protocols and materials databases
Antibodypediai | 18128, 300 antibodies |
Genome annotation databases
Ensembli | ENST00000513745; ENSP00000421755; ENSG00000108846 |
UCSCi | uc060hlv.1, human |
Organism-specific databases
HGNCi | HGNC:54, ABCC3 |
OpenTargetsi | ENSG00000108846 |
VEuPathDBi | HostDB:ENSG00000108846.15 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000161624 |
HOGENOMi | CLU_932359_0_0_1 |
Miscellaneous databases
ChiTaRSi | ABCC3, human |
Gene expression databases
Bgeei | ENSG00000108846, Expressed in left adrenal gland and 180 other tissues |
ExpressionAtlasi | H0Y8Q6, baseline and differential |
Family and domain databases
Gene3Di | 1.20.1560.10, 2 hits |
InterProi | View protein in InterPro IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf |
Pfami | View protein in Pfam PF00664, ABC_membrane, 2 hits |
SUPFAMi | SSF90123, SSF90123, 1 hit |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H0Y8Q6_HUMAN | |
Accessioni | H0Y8Q6Primary (citable) accession number: H0Y8Q6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 22, 2012 |
Last sequence update: | February 22, 2012 | |
Last modified: | February 10, 2021 | |
This is version 56 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |