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Protein
Submitted name:

3-hydroxy-3-methylglutaryl-coenzyme A reductase

Gene

HMGCR

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
3-hydroxy-3-methylglutaryl-coenzyme A reductaseImported
Gene namesi
Name:HMGCRImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000113161.15
HGNCiHGNC:5006 HMGCR

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000113161

PTM / Processingi

Proteomic databases

MaxQBiH0Y8K6
PeptideAtlasiH0Y8K6
PRIDEiH0Y8K6

Expressioni

Gene expression databases

BgeeiENSG00000113161 Expressed in 227 organ(s), highest expression level in adrenal tissue
ExpressionAtlasiH0Y8K6 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH0Y8K6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00910000144151

Family and domain databases

Gene3Di3.30.70.420, 1 hit
3.90.770.10, 2 hits
InterProiView protein in InterPro
IPR002202 HMG_CoA_Rdtase
IPR023074 HMG_CoA_Rdtase_cat_sf
IPR023076 HMG_CoA_Rdtase_CS
IPR009023 HMG_CoA_Rdtase_NAD(P)-bd_sf
IPR009029 HMG_CoA_Rdtase_sub-bd_dom_sf
PANTHERiPTHR10572 PTHR10572, 2 hits
PfamiView protein in Pfam
PF00368 HMG-CoA_red, 2 hits
PRINTSiPR00071 HMGCOARDTASE
SUPFAMiSSF55035 SSF55035, 1 hit
SSF56542 SSF56542, 1 hit
PROSITEiView protein in PROSITE
PS01192 HMG_COA_REDUCTASE_3, 1 hit
PS50065 HMG_COA_REDUCTASE_4, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

H0Y8K6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XHEYFPEMQI LAVSGNYCTD KKPAAINWIE GRGKSVVCEA VIPAKVVREV
60 70 80 90 100
LKTTTEAMIE VNINKNLVGS AMAGSIGGYN AHAANIVTAI YIACGQMLGV
110 120 130 140 150
QGACKDNPGE NARQLARIVC GTVMAGELSL MAALAAGHLV KSHMIHNRSK
160
INLQDLQGAC TKKTA
Length:165
Mass (Da):17,462
Last modified:February 22, 2012 - v1
Checksum:i49C8F9E48A65019F
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P04035HMDH_HUMAN
3-hydroxy-3-methylglutaryl-coenzyme...
HMGCR
888Annotation score:
D6RIW0D6RIW0_HUMAN
3-hydroxy-3-methylglutaryl-coenzyme...
HMGCR
111Annotation score:
H0Y8F6H0Y8F6_HUMAN
3-hydroxy-3-methylglutaryl-coenzyme...
HMGCR
115Annotation score:
C9JKX7C9JKX7_HUMAN
3-hydroxy-3-methylglutaryl-coenzyme...
HMGCR
18Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008897 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000509085; ENSP00000421378; ENSG00000113161
UCSCiuc063epv.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008897 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH0Y8K6
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiH0Y8K6
PeptideAtlasiH0Y8K6
PRIDEiH0Y8K6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000509085; ENSP00000421378; ENSG00000113161
UCSCiuc063epv.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000113161.15
HGNCiHGNC:5006 HMGCR
OpenTargetsiENSG00000113161
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00910000144151

Miscellaneous databases

ChiTaRSiHMGCR human

Gene expression databases

BgeeiENSG00000113161 Expressed in 227 organ(s), highest expression level in adrenal tissue
ExpressionAtlasiH0Y8K6 baseline and differential

Family and domain databases

Gene3Di3.30.70.420, 1 hit
3.90.770.10, 2 hits
InterProiView protein in InterPro
IPR002202 HMG_CoA_Rdtase
IPR023074 HMG_CoA_Rdtase_cat_sf
IPR023076 HMG_CoA_Rdtase_CS
IPR009023 HMG_CoA_Rdtase_NAD(P)-bd_sf
IPR009029 HMG_CoA_Rdtase_sub-bd_dom_sf
PANTHERiPTHR10572 PTHR10572, 2 hits
PfamiView protein in Pfam
PF00368 HMG-CoA_red, 2 hits
PRINTSiPR00071 HMGCOARDTASE
SUPFAMiSSF55035 SSF55035, 1 hit
SSF56542 SSF56542, 1 hit
PROSITEiView protein in PROSITE
PS01192 HMG_COA_REDUCTASE_3, 1 hit
PS50065 HMG_COA_REDUCTASE_4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH0Y8K6_HUMAN
AccessioniPrimary (citable) accession number: H0Y8K6
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: September 12, 2018
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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