UniProtKB - H0Y8E6 (H0Y8E6_HUMAN)
Protein
DNA replication licensing factor MCM2
Gene
MCM2
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:3.6.4.12ARBA annotation
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- DNA binding Source: UniProtKB-KW
- DNA helicase activity Source: UniProtKB-EC
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- DNA replication initiation Source: InterPro
- negative regulation of DNA helicase activity Source: InterPro
Keywordsi
Molecular function | DNA-bindingUniRule annotationARBA annotation, HelicaseARBA annotation, Hydrolase |
Biological process | Cell cycleARBA annotation, DNA replicationARBA annotation |
Ligand | ATP-binding, Metal-bindingARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:MCM2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000073111.13 |
HGNCi | HGNC:6944, MCM2 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Cytoskeleton
- microtubule cytoskeleton Source: HPA
Nucleus
- nucleoplasm Source: HPA
Other locations
- MCM complex Source: InterPro
Keywords - Cellular componenti
NucleusARBA annotationPTM / Processingi
Proteomic databases
MaxQBi | H0Y8E6 |
PeptideAtlasi | H0Y8E6 |
PRIDEi | H0Y8E6 |
ProteomicsDBi | 35665 |
PTM databases
SwissPalmi | H0Y8E6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000073111, Expressed in oocyte and 203 other tissues |
ExpressionAtlasi | H0Y8E6, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 409 – 611 | MCMInterPro annotationAdd BLAST | 203 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 36 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 619 – 640 | DisorderedSequence analysisAdd BLAST | 22 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 21 | PolyampholyteSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT01010000222249 |
HOGENOMi | CLU_000995_7_2_1 |
Family and domain databases
InterProi | View protein in InterPro IPR031327, MCM IPR008045, MCM2 IPR018525, MCM_CS IPR001208, MCM_dom IPR041562, MCM_lid IPR027925, MCM_N IPR033762, MCM_OB IPR012340, NA-bd_OB-fold IPR027417, P-loop_NTPase |
PANTHERi | PTHR11630, PTHR11630, 1 hit PTHR11630:SF44, PTHR11630:SF44, 1 hit |
Pfami | View protein in Pfam PF00493, MCM, 1 hit PF17855, MCM_lid, 1 hit PF14551, MCM_N, 1 hit PF17207, MCM_OB, 1 hit |
PRINTSi | PR01657, MCMFAMILY PR01658, MCMPROTEIN2 |
SMARTi | View protein in SMART SM00350, MCM, 1 hit |
SUPFAMi | SSF50249, SSF50249, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00847, MCM_1, 1 hit PS50051, MCM_2, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
H0Y8E6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
XSDEEDEERP ARKRRQVERA TEDGEEDEEM IESIENLEDL KGHSVREWVS
60 70 80 90 100
MAGPRLEIHH RFKNFLRTHV DSHGHNVFKE RISDMCKENR ESLVVNYEDL
110 120 130 140 150
AAREHVLAYF LPEAPAELLQ IFDEAALEVV LAMYPKYDRI TNHIHVRISH
160 170 180 190 200
LPLVEELRSL RQLHLNQLIR TSGVVTSCTG VLPQLSMVKY NCNKCNFVLG
210 220 230 240 250
PFCQSQNQEV KPGSCPECQS AGPFEVNMEE TIYQNYQRIR IQESPGKVAA
260 270 280 290 300
GRLPRSKDAI LLADLVDSCK PGDEIELTGI YHNNYDGSLN TANGFPVFAT
310 320 330 340 350
VILANHVAKK DNKVAVGELT DEDVKMITSL SKDQQIGEKE SSRNASLAEA
360 370 380 390 400
GIGAIPSQLL AIEPSLRRSG VPIGEVGVSQ RQEARSFSSA NTHWFLEDLL
410 420 430 440 450
GPSCRDTMIF ASIAPSIYGH EDIKRGLALA LFGGEPKNPG GKHKVRGDIN
460 470 480 490 500
VLLCGDPGTA KSQFLKYIEK VSSRAIFTTG QGASAVGLTA YVQRHPVSRE
510 520 530 540 550
WTLEAGALVL ADRGVCLIDE FDKMNDQDRT SIHEAMEQQS ISISKAGIVT
560 570 580 590 600
SLQARCTVIA AANPIGGRYD PSLTFSENVD LTEPIISRFD ILCVVRDTVD
610 620 630 640 650
PVQDEMLARF VVGSHVRHHP SNKEEEGLAN GSAAEPAMPN TYGVEPLPQE
660 670 680 690 700
VLKKYIIYAK ERVHPKLNQM DQDKVAKMYS DLRKESMATG SIPITVRHIE
710 720 730 740 750
SMIRMAEAHA RIHLRDYVIE DDVNMAIRVM LESFIDTQKF SVMRSMRKTF
760 770 780 790 800
ARYLSFRRDN NELLLFILKQ LVAEQVTYQR NRFGAQQDTI EVPEKDLVDK
810 820 830
ARQINIHNLS AFYDSELFRM NKFSHDLKRK MILQQF
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP49736 | MCM2_HUMAN | DNA replication licensing factor MC... | MCM2 BM28, CCNL1, CDCL1, KIAA0030 | 904 | Annotation score: | ||
C9J013 | C9J013_HUMAN | DNA replication licensing factor MC... | MCM2 | 103 | Annotation score: | ||
C9JZ21 | C9JZ21_HUMAN | DNA replication licensing factor MC... | MCM2 | 128 | Annotation score: | ||
F8WDM3 | F8WDM3_HUMAN | DNA replication licensing factor MC... | MCM2 | 146 | Annotation score: | ||
H7C4N9 | H7C4N9_HUMAN | DNA replication licensing factor MC... | MCM2 | 91 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC023593 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000491422; ENSP00000420528; ENSG00000073111 |
UCSCi | uc062nmf.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC023593 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
PTM databases
SwissPalmi | H0Y8E6 |
Proteomic databases
MaxQBi | H0Y8E6 |
PeptideAtlasi | H0Y8E6 |
PRIDEi | H0Y8E6 |
ProteomicsDBi | 35665 |
Protocols and materials databases
Antibodypediai | 4369, 987 antibodies |
Genome annotation databases
Ensembli | ENST00000491422; ENSP00000420528; ENSG00000073111 |
UCSCi | uc062nmf.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000073111.13 |
HGNCi | HGNC:6944, MCM2 |
OpenTargetsi | ENSG00000073111 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT01010000222249 |
HOGENOMi | CLU_000995_7_2_1 |
Miscellaneous databases
ChiTaRSi | MCM2, human |
Gene expression databases
Bgeei | ENSG00000073111, Expressed in oocyte and 203 other tissues |
ExpressionAtlasi | H0Y8E6, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR031327, MCM IPR008045, MCM2 IPR018525, MCM_CS IPR001208, MCM_dom IPR041562, MCM_lid IPR027925, MCM_N IPR033762, MCM_OB IPR012340, NA-bd_OB-fold IPR027417, P-loop_NTPase |
PANTHERi | PTHR11630, PTHR11630, 1 hit PTHR11630:SF44, PTHR11630:SF44, 1 hit |
Pfami | View protein in Pfam PF00493, MCM, 1 hit PF17855, MCM_lid, 1 hit PF14551, MCM_N, 1 hit PF17207, MCM_OB, 1 hit |
PRINTSi | PR01657, MCMFAMILY PR01658, MCMPROTEIN2 |
SMARTi | View protein in SMART SM00350, MCM, 1 hit |
SUPFAMi | SSF50249, SSF50249, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00847, MCM_1, 1 hit PS50051, MCM_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H0Y8E6_HUMAN | |
Accessioni | H0Y8E6Primary (citable) accession number: H0Y8E6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 22, 2012 |
Last sequence update: | February 22, 2012 | |
Last modified: | December 2, 2020 | |
This is version 77 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |