UniProtKB - H0Y859 (H0Y859_HUMAN)
Protein
Submitted name:
A disintegrin and metalloproteinase with thrombospondin motifs 9
Gene
ADAMTS9
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- metalloendopeptidase activity Source: InterPro
- zinc ion binding Source: InterPro
Keywordsi
Ligand | Metal-bindingARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: A disintegrin and metalloproteinase with thrombospondin motifs 9Imported |
Gene namesi | Name:ADAMTS9Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13202, ADAMTS9 |
VEuPathDBi | HostDB:ENSG00000163638.13 |
Subcellular locationi
Endoplasmic reticulum
- endoplasmic reticulum Source: HPA
Other locations
- intracellular membrane-bounded organelle Source: HPA
Expressioni
Gene expression databases
Bgeei | ENSG00000163638, Expressed in left coronary artery and 193 other tissues |
ExpressionAtlasi | H0Y859, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 791 – 991 | GONInterPro annotationAdd BLAST | 201 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 345 – 386 | DisorderedSequence analysisAdd BLAST | 42 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 345 – 362 | PolarSequence analysisAdd BLAST | 18 | |
Compositional biasi | 369 – 386 | PolarSequence analysisAdd BLAST | 18 |
Phylogenomic databases
GeneTreei | ENSGT00940000156409 |
HOGENOMi | CLU_000660_0_0_1 |
Family and domain databases
Gene3Di | 2.20.100.10, 12 hits |
InterProi | View protein in InterPro IPR012314, Pept_M12B_GON-ADAMTSs IPR000884, TSP1_rpt IPR036383, TSP1_rpt_sf |
Pfami | View protein in Pfam PF08685, GON, 1 hit |
SMARTi | View protein in SMART SM00209, TSP1, 12 hits |
SUPFAMi | SSF82895, SSF82895, 12 hits |
PROSITEi | View protein in PROSITE PS51046, GON, 1 hit PS50092, TSP1, 12 hits |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
H0Y859-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
XECSAQCGLG YRTLDIYCAK YSRLDGKTEK VDDGFCSSHP KPSNREKCSG
60 70 80 90 100
ECNTGGWRYS AWTECSKSCD GGTQRRRAIC VNTRNDVLDD SKCTHQEKVT
110 120 130 140 150
IQRCSEFPCP QWKSGDWSEC LVTCGKGHKH RQVWCQFGED RLNDRMCDPE
160 170 180 190 200
TKPTSMQTCQ QPECASWQAG PWGQCSVTCG QGYQLRAVKC IIGTYMSVVD
210 220 230 240 250
DNDCNAATRP TDTQDCELPS CHPPPAAPET RRSTYSAPRT QWRFGSWTPC
260 270 280 290 300
SATCGKGTRM RYVSCRDENG SVADESACAT LPRPVAKEEC SVTPCGQWKA
310 320 330 340 350
LDWSSCSVTC GQGRATRQVM CVNYSDHVID RSECDQDYIP ETDQDCSMSP
360 370 380 390 400
CPQRTPDSGL AQHPFQNEDY RPRSASPSRT HVLGGNQWRT GPWGACSSTC
410 420 430 440 450
AGGSQRRVVV CQDENGYTAN DCVERIKPDE QRACESGPCP QWAYGNWGEC
460 470 480 490 500
TKLCGGGIRT RLVVCQRSNG ERFPDLSCEI LDKPPDREQC NTHACPHDAA
510 520 530 540 550
WSTGPWSSCS VSCGRGHKQR NVYCMAKDGS HLESDYCKHL AKPHGHRKCR
560 570 580 590 600
GGRCPKWKAG AWSQCSVSCG RGVQQRHVGC QIGTHKIARE TECNPYTRPE
610 620 630 640 650
SERDCQGPRC PLYTWRAEEW QECTKTCGEG SRYRKVVCVD DNKNEVHGAR
660 670 680 690 700
CDVSKRPVDR ESCSLQPCEY VWITGEWSEC SVTCGKGYKQ RLVSCSEIYT
710 720 730 740 750
GKENYEYSYQ TTINCPGTQP PSVHPCYLRD CPVSATWRVG NWGSCSVSCG
760 770 780 790 800
VGVMQRSVQC LTNEDQPSHL CHTDLKPEER KTCRNVYNCE LPQNCKEVKR
810 820 830 840 850
LKGASEDGEY FLMIRGKLLK IFCAGMHSDH PKEYVTLVHG DSENFSEVYG
860 870 880 890 900
HRLHNPTECP YNGSRRDDCQ CRKDYTAAGF SSFQKIRIDL TSMQIITTDL
910 920 930 940 950
QFARTSEGHP VPFATAGDCY SAAKCPQGRF SINLYGTGLS LTESARWISQ
960 970 980 990
GNYAVSDIKK SPDGTRVVGK CGGYCGKCTP SSGTGLEVRV L
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9P2N4 | ATS9_HUMAN | A disintegrin and metalloproteinase... | ADAMTS9 KIAA1312 | 1,935 | Annotation score: | ||
C9JWI2 | C9JWI2_HUMAN | A disintegrin and metalloproteinase... | ADAMTS9 | 488 | Annotation score: | ||
A0A087WTS1 | A0A087WTS1_HUMAN | A disintegrin and metalloproteinase... | ADAMTS9 | 69 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC096888 Genomic DNA No translation available. AC122178 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000481060; ENSP00000417521; ENSG00000163638 |
UCSCi | uc062lfy.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC096888 Genomic DNA No translation available. AC122178 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | H0Y859 |
ProteomicsDBi | 35592 |
Protocols and materials databases
Antibodypediai | 31780, 97 antibodies |
Genome annotation databases
Ensembli | ENST00000481060; ENSP00000417521; ENSG00000163638 |
UCSCi | uc062lfy.1, human |
Organism-specific databases
HGNCi | HGNC:13202, ADAMTS9 |
OpenTargetsi | ENSG00000163638 |
VEuPathDBi | HostDB:ENSG00000163638.13 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000156409 |
HOGENOMi | CLU_000660_0_0_1 |
Miscellaneous databases
ChiTaRSi | ADAMTS9, human |
Gene expression databases
Bgeei | ENSG00000163638, Expressed in left coronary artery and 193 other tissues |
ExpressionAtlasi | H0Y859, baseline and differential |
Family and domain databases
Gene3Di | 2.20.100.10, 12 hits |
InterProi | View protein in InterPro IPR012314, Pept_M12B_GON-ADAMTSs IPR000884, TSP1_rpt IPR036383, TSP1_rpt_sf |
Pfami | View protein in Pfam PF08685, GON, 1 hit |
SMARTi | View protein in SMART SM00209, TSP1, 12 hits |
SUPFAMi | SSF82895, SSF82895, 12 hits |
PROSITEi | View protein in PROSITE PS51046, GON, 1 hit PS50092, TSP1, 12 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H0Y859_HUMAN | |
Accessioni | H0Y859Primary (citable) accession number: H0Y859 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 22, 2012 |
Last sequence update: | February 22, 2012 | |
Last modified: | April 7, 2021 | |
This is version 51 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |