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UniProtKB - H0Y835 (H0Y835_HUMAN)
Protein
Rho GTPase-activating protein 26
Gene
ARHGAP26
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- GTPase activator activity Source: InterPro
GO - Biological processi
- actin cytoskeleton organization Source: InterPro
- regulation of small GTPase mediated signal transduction Source: InterPro
- signal transduction Source: InterPro
Names & Taxonomyi
Protein namesi | Recommended name: Rho GTPase-activating protein 26ARBA annotationAlternative name(s): Rho-type GTPase-activating protein 26ARBA annotation |
Gene namesi | Name:ARHGAP26Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17073, ARHGAP26 |
VEuPathDBi | HostDB:ENSG00000145819 |
Subcellular locationi
Cytoskeleton
- cytoskeleton ARBA annotation
Other locations
- focal adhesion ARBA annotation
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: UniProtKB-KW
- focal adhesion Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell junctionARBA annotationPTM / Processingi
Proteomic databases
MaxQBi | H0Y835 |
PeptideAtlasi | H0Y835 |
PRIDEi | H0Y835 |
ProteomicsDBi | 35574 |
Expressioni
Gene expression databases
Bgeei | ENSG00000145819, Expressed in colon and 220 other tissues |
ExpressionAtlasi | H0Y835, baseline and differential |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 140 | Rho-GAPInterPro annotationAdd BLAST | 140 | |
Domaini | 236 – 294 | SH3InterPro annotationAdd BLAST | 59 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 154 – 173 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 202 – 232 | DisorderedSequence analysisAdd BLAST | 31 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 202 – 223 | Polar residuesSequence analysisAdd BLAST | 22 |
Keywords - Domaini
SH3 domainPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000157254 |
Family and domain databases
CDDi | cd12064, SH3_GRAF, 1 hit |
Gene3Di | 1.10.555.10, 1 hit |
InterProi | View protein in InterPro IPR030061, GRAF IPR035481, GRAF_SH3 IPR008936, Rho_GTPase_activation_prot IPR000198, RhoGAP_dom IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR12552:SF4, PTHR12552:SF4, 2 hits |
Pfami | View protein in Pfam PF00620, RhoGAP, 1 hit PF14604, SH3_9, 1 hit |
SMARTi | View protein in SMART SM00324, RhoGAP, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF48350, SSF48350, 1 hit SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS50238, RHOGAP, 1 hit PS50002, SH3, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All
H0Y835-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
XPKTASETET DICAEWEIKT ITSALKTYLR MLPGPLMMYQ FQRSFIKAAK
60 70 80 90 100
LENQESRVSE IHSLVHRLPE KNRQMLQLLM NHLANVANNH KQNLMTVANL
110 120 130 140 150
GVVFGPTLLR PQEETVAAIM DIKFQNIVIE ILIENHEKIF NTVPDMPLTN
160 170 180 190 200
AQLHLSRKKS SDSKPPSCSE RPLTLFHTVQ STEKQEQRNS IINSSLESVS
210 220 230 240 250
SNPNSILNSS SSLQPNMNSS DPDLAVVKPT RPNSLTPFRK AKALYACKAE
260 270 280 290
HDSELSFTAG TVFDNVHPSQ EPGWLEGTLN GKTGLIPENY VEFL
Computationally mapped potential isoform sequencesi
There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9UNA1 | RHG26_HUMAN | Rho GTPase-activating protein 26 | ARHGAP26 GRAF, KIAA0621, OPHN1L | 814 | Annotation score: | ||
A0A2R8YGB3 | A0A2R8YGB3_HUMAN | Rho GTPase-activating protein 26 | ARHGAP26 | 686 | Annotation score: | ||
H0Y4P9 | H0Y4P9_HUMAN | Rho GTPase-activating protein 26 | ARHGAP26 | 388 | Annotation score: | ||
C9J6V4 | C9J6V4_HUMAN | Rho GTPase-activating protein 26 | ARHGAP26 | 91 | Annotation score: | ||
A0A2R8YDK5 | A0A2R8YDK5_HUMAN | Rho GTPase-activating protein 26 | ARHGAP26 | 161 | Annotation score: | ||
H7BZE1 | H7BZE1_HUMAN | Rho GTPase-activating protein 26 | ARHGAP26 | 154 | Annotation score: | ||
H7C1J1 | H7C1J1_HUMAN | Rho GTPase-activating protein 26 | ARHGAP26 | 127 | Annotation score: | ||
H7C205 | H7C205_HUMAN | Rho GTPase-activating protein 26 | ARHGAP26 | 97 | Annotation score: | ||
H7C3P8 | H7C3P8_HUMAN | Rho GTPase-activating protein 26 | ARHGAP26 | 127 | Annotation score: | ||
A0A2R8Y5C0 | A0A2R8Y5C0_HUMAN | Rho GTPase-activating protein 26 | ARHGAP26 | 338 | Annotation score: | ||
There is more potential isoformShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004782 Genomic DNA No translation available. AC005348 Genomic DNA No translation available. AC005574 Genomic DNA No translation available. AC008533 Genomic DNA No translation available. AC012630 Genomic DNA No translation available. KC877124 Genomic DNA No translation available. KC877138 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000418236; ENSP00000416889; ENSG00000145819 |
UCSCi | uc063ifq.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004782 Genomic DNA No translation available. AC005348 Genomic DNA No translation available. AC005574 Genomic DNA No translation available. AC008533 Genomic DNA No translation available. AC012630 Genomic DNA No translation available. KC877124 Genomic DNA No translation available. KC877138 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
Proteomic databases
MaxQBi | H0Y835 |
PeptideAtlasi | H0Y835 |
PRIDEi | H0Y835 |
ProteomicsDBi | 35574 |
Protocols and materials databases
Antibodypediai | 27437, 254 antibodies from 33 providers |
Genome annotation databases
Ensembli | ENST00000418236; ENSP00000416889; ENSG00000145819 |
UCSCi | uc063ifq.1, human |
Organism-specific databases
HGNCi | HGNC:17073, ARHGAP26 |
OpenTargetsi | ENSG00000145819 |
VEuPathDBi | HostDB:ENSG00000145819 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000157254 |
Miscellaneous databases
ChiTaRSi | ARHGAP26, human |
Gene expression databases
Bgeei | ENSG00000145819, Expressed in colon and 220 other tissues |
ExpressionAtlasi | H0Y835, baseline and differential |
Family and domain databases
CDDi | cd12064, SH3_GRAF, 1 hit |
Gene3Di | 1.10.555.10, 1 hit |
InterProi | View protein in InterPro IPR030061, GRAF IPR035481, GRAF_SH3 IPR008936, Rho_GTPase_activation_prot IPR000198, RhoGAP_dom IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR12552:SF4, PTHR12552:SF4, 2 hits |
Pfami | View protein in Pfam PF00620, RhoGAP, 1 hit PF14604, SH3_9, 1 hit |
SMARTi | View protein in SMART SM00324, RhoGAP, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF48350, SSF48350, 1 hit SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS50238, RHOGAP, 1 hit PS50002, SH3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | H0Y835_HUMAN | |
Accessioni | H0Y835Primary (citable) accession number: H0Y835 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 22, 2012 |
Last sequence update: | February 22, 2012 | |
Last modified: | January 19, 2022 | |
This is version 67 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |