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UniProtKB - H0Y804 (H0Y804_HUMAN)
Protein
Submitted name:
Aldo-keto reductase family 1 member C1
Gene
AKR1C1
Organism
Homo sapiens (Human)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 51 | Lowers pKa of active site TyrUniRule annotation | 1 | |
Binding sitei | 84 | SubstrateUniRule annotation | 1 |
GO - Molecular functioni
- D-threo-aldose 1-dehydrogenase activity Source: InterPro
Keywordsi
Molecular function | OxidoreductaseARBA annotation |
Ligand | NADPARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Aldo-keto reductase family 1 member C1Imported |
Gene namesi | Name:AKR1C1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:384, AKR1C1 |
VEuPathDBi | HostDB:ENSG00000187134 |
PTM / Processingi
Proteomic databases
MaxQBi | H0Y804 |
PRIDEi | H0Y804 |
ProteomicsDBi | 35555 |
PTM databases
SwissPalmi | H0Y804 |
Expressioni
Gene expression databases
Bgeei | ENSG00000187134, Expressed in islet of Langerhans and 124 other tissues |
ExpressionAtlasi | H0Y804, baseline and differential |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 248 | Aldo_ket_redInterPro annotationAdd BLAST | 221 |
Sequence similaritiesi
Belongs to the aldo/keto reductase family.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00940000163208 |
HOGENOMi | CLU_023205_0_0_1 |
Family and domain databases
Gene3Di | 3.20.20.100, 1 hit |
InterProi | View protein in InterPro IPR020471, AKR IPR018170, Aldo/ket_reductase_CS IPR023210, NADP_OxRdtase_dom IPR036812, NADP_OxRdtase_dom_sf |
Pfami | View protein in Pfam PF00248, Aldo_ket_red, 1 hit |
PIRSFi | PIRSF000097, AKR, 2 hits |
PRINTSi | PR00069, ALDKETRDTASE |
SUPFAMi | SSF51430, SSF51430, 1 hit |
PROSITEi | View protein in PROSITE PS00062, ALDOKETO_REDUCTASE_2, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
H0Y804-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
XSKYQCVKLN DGHFMPVLGF GTYAPAEVGL AIRSKIADGS VKREDIFYTS
60 70 80 90 100
KLWCNSHRPE LVRPALERSL KNLQLDYVDL YLIHFPVSVK PGEEVIPKDE
110 120 130 140 150
NGKILFDTVD LCATWEAVEK CKDAGLAKSI GVSNFNRRQL EMILNKPGLK
160 170 180 190 200
YKPVCNQVEC HPYFNQRKLL DFCKSKDIVL VAYSALGSHR EEPWVDPNSP
210 220 230 240
VLLEDPVLCA LAKKHKRTPA LIALRYQLQR GVVVLAKSYN EQRIRQNV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ04828 | AK1C1_HUMAN | Aldo-keto reductase family 1 member... | AKR1C1 DDH, DDH1 | 323 | Annotation score: | ||
A6NHU4 | A6NHU4_HUMAN | Aldo-keto reductase family 1 member... | AKR1C1 | 205 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 | |
Non-terminal residuei | 248 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC091817 Genomic DNA No translation available. AL713867 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000442997; ENSP00000416415; ENSG00000187134 |
UCSCi | uc057rih.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC091817 Genomic DNA No translation available. AL713867 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
PTM databases
SwissPalmi | H0Y804 |
Proteomic databases
MaxQBi | H0Y804 |
PRIDEi | H0Y804 |
ProteomicsDBi | 35555 |
Protocols and materials databases
Antibodypediai | 23969, 330 antibodies from 37 providers |
Genome annotation databases
Ensembli | ENST00000442997; ENSP00000416415; ENSG00000187134 |
UCSCi | uc057rih.1, human |
Organism-specific databases
HGNCi | HGNC:384, AKR1C1 |
OpenTargetsi | ENSG00000187134 |
VEuPathDBi | HostDB:ENSG00000187134 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000163208 |
HOGENOMi | CLU_023205_0_0_1 |
Miscellaneous databases
ChiTaRSi | AKR1C1, human |
Gene expression databases
Bgeei | ENSG00000187134, Expressed in islet of Langerhans and 124 other tissues |
ExpressionAtlasi | H0Y804, baseline and differential |
Family and domain databases
Gene3Di | 3.20.20.100, 1 hit |
InterProi | View protein in InterPro IPR020471, AKR IPR018170, Aldo/ket_reductase_CS IPR023210, NADP_OxRdtase_dom IPR036812, NADP_OxRdtase_dom_sf |
Pfami | View protein in Pfam PF00248, Aldo_ket_red, 1 hit |
PIRSFi | PIRSF000097, AKR, 2 hits |
PRINTSi | PR00069, ALDKETRDTASE |
SUPFAMi | SSF51430, SSF51430, 1 hit |
PROSITEi | View protein in PROSITE PS00062, ALDOKETO_REDUCTASE_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | H0Y804_HUMAN | |
Accessioni | H0Y804Primary (citable) accession number: H0Y804 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 22, 2012 |
Last sequence update: | February 22, 2012 | |
Last modified: | January 19, 2022 | |
This is version 54 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |