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Entry version 61 (07 Oct 2020)
Sequence version 1 (22 Feb 2012)
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Protein

Protein-tyrosine-phosphatase

Gene

PTPRF

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphataseARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein-tyrosine-phosphataseARBA annotation (EC:3.1.3.48ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTPRFImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000142949.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9670, PTPRF

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei675 – 698HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000142949

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

GlycoproteinARBA annotation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
H0Y7Z9

PeptideAtlas

More...
PeptideAtlasi
H0Y7Z9

PRoteomics IDEntifications database

More...
PRIDEi
H0Y7Z9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
35550

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000142949, Expressed in epithelium of mammary gland and 239 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
H0Y7Z9, baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 35Fibronectin type-IIIInterPro annotationAdd BLAST35
Domaini39 – 129Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini134 – 233Fibronectin type-IIIInterPro annotationAdd BLAST100
Domaini234 – 328Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini332 – 424Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini428 – 512Fibronectin type-IIIInterPro annotationAdd BLAST85
Domaini777 – 1032Tyrosine-protein phosphataseInterPro annotationAdd BLAST256
Domaini952 – 1023TYR_PHOSPHATASE_2InterPro annotationAdd BLAST72
Domaini1064 – 1323Tyrosine-protein phosphataseInterPro annotationAdd BLAST260
Domaini1241 – 1314TYR_PHOSPHATASE_2InterPro annotationAdd BLAST74

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni734 – 759DisorderedSequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi734 – 754PolarSequence analysisAdd BLAST21

Keywords - Domaini

SignalARBA annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155060

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063, FN3, 6 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 6 hits
3.90.190.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold
IPR029021, Prot-tyrosine_phosphatase-like
IPR000242, PTPase_domain
IPR016130, Tyr_Pase_AS
IPR003595, Tyr_Pase_cat
IPR000387, TYR_PHOSPHATASE_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041, fn3, 4 hits
PF00102, Y_phosphatase, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00700, PRTYPHPHTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060, FN3, 5 hits
SM00194, PTPc, 2 hits
SM00404, PTPc_motif, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265, SSF49265, 4 hits
SSF52799, SSF52799, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853, FN3, 6 hits
PS00383, TYR_PHOSPHATASE_1, 2 hits
PS50056, TYR_PHOSPHATASE_2, 2 hits
PS50055, TYR_PHOSPHATASE_PTP, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

H0Y7Z9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XSLLPGITYS LRVLAFTAVG DGPPSPTIQV KTQQGVPAQP ADFQAEVESD
60 70 80 90 100
TRIQLSWLLP PQERIIMYEL VYWAAEDEDQ QHKVTFDPTS SYTLEDLKPD
110 120 130 140 150
TLYRFQLAAR SDMGVGVFTP TIEARTAQSM PSGPPRKVEV EPLNSTAVHV
160 170 180 190 200
YWKLPVPSKQ HGQIRGYQVT YVRLENGEPR GLPIIQDVML AEAQETTISG
210 220 230 240 250
LTPETTYSVT VAAYTTKGDG ARSKPKIVTT TGAVPGRPTM MISTTAMNTA
260 270 280 290 300
LLQWHPPKEL PGELLGYRLQ YCRADEARPN TIDFGKDDQH FTVTGLHKGT
310 320 330 340 350
TYIFRLAAKN RAGLGEEFEK EIRTPEDLPS GFPQNLHVTG LTTSTTELAW
360 370 380 390 400
DPPVLAERNG RIISYTVVFR DINSQQELQN ITTDTRFTLT GLKPDTTYDI
410 420 430 440 450
KVRAWTSKGS GPLSPSIQSR TMPVEQVFAK NFRVAAAMKT SVLLSWEVPD
460 470 480 490 500
SYKSAVPFKI LYNGQSVEVD GHSMRKLIAD LQPNTEYSFV LMNRGSSAGG
510 520 530 540 550
LQHLVSIRTA PDLLPHKPLP ASAYIEDGRF DLSMPHVQDP SLVRWFYIVV
560 570 580 590 600
VPIDRVGGSM LTPRWSTPEE LELDELLEAI EQGGEEQRRR RRQAERLKPY
610 620 630 640 650
VAAQLDVLPE TFTLGDKKNY RGFYNRPLSP DLSYQCFVLA SLKEPMDQKR
660 670 680 690 700
YASSPYSDEI VVQVTPAQQQ EEPEMLWVTG PVLAVILIIL IVIAILLFKR
710 720 730 740 750
KRTHSPSSKD EQSIGLKDSL LAHSSDPVEM RRLNYQTPGS SVPSCPNTSS
760 770 780 790 800
MRDHPPIPIT DLADNIERLK ANDGLKFSQE YESIDPGQQF TWENSNLEVN
810 820 830 840 850
KPKNRYANVI AYDHSRVILT SIDGVPGSDY INANYIDGYR KQNAYIATQG
860 870 880 890 900
PLPETMGDFW RMVWEQRTAT VVMMTRLEEK SRVKCDQYWP ARGTETCGLI
910 920 930 940 950
QVTLLDTVEL ATYTVRTFAL HKSGSSEKRE LRQFQFMAWP DHGVPEYPTP
960 970 980 990 1000
ILAFLRRVKA CNPLDAGPMV VHCSAGVGRT GCFIVIDAML ERMKHEKTVD
1010 1020 1030 1040 1050
IYGHVTCMRS QRNYMVQTED QYVFIHEALL EAATCGHTEV PARNLYAHIQ
1060 1070 1080 1090 1100
KLGQVPPGES VTAMELEFKL LASSKAHTSR FISANLPCNK FKNRLVNIMP
1110 1120 1130 1140 1150
YELTRVCLQP IRGVEGSDYI NASFLDGYRQ QKAYIATQGP LAESTEDFWR
1160 1170 1180 1190 1200
MLWEHNSTII VMLTKLREMG REKCHQYWPA ERSARYQYFV VDPMAEYNMP
1210 1220 1230 1240 1250
QYILREFKVT DARDGQSRTI RQFQFTDWPE QGVPKTGEGF IDFIGQVHKT
1260 1270 1280 1290 1300
KEQFGQDGPI TVHCSAGVGR TGVFITLSIV LERMRYEGVV DMFQTVKTLR
1310 1320 1330
TQRPAMVQTE DQYQLCYRAA LEYLGSFDHY AT
Length:1,332
Mass (Da):150,464
Last modified:February 22, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2E785A63B1DCDEDC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P10586PTPRF_HUMAN
Receptor-type tyrosine-protein phos...
PTPRF LAR
1,907Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y4H1H0Y4H1_HUMAN
Protein-tyrosine-phosphatase
PTPRF
1,291Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y6Z7H0Y6Z7_HUMAN
Protein-tyrosine-phosphatase
PTPRF
1,553Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y380H0Y380_HUMAN
Protein-tyrosine-phosphatase
PTPRF
979Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A437A2A437_HUMAN
Receptor-type tyrosine-protein phos...
PTPRF
262Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC092815 Genomic DNA No translation available.
AL583862 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000414879; ENSP00000416343; ENSG00000142949

UCSC genome browser

More...
UCSCi
uc057fol.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092815 Genomic DNA No translation available.
AL583862 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Proteomic databases

MaxQBiH0Y7Z9
PeptideAtlasiH0Y7Z9
PRIDEiH0Y7Z9
ProteomicsDBi35550

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
2499, 299 antibodies

Genome annotation databases

EnsembliENST00000414879; ENSP00000416343; ENSG00000142949
UCSCiuc057fol.1, human

Organism-specific databases

EuPathDBiHostDB:ENSG00000142949.16
HGNCiHGNC:9670, PTPRF
OpenTargetsiENSG00000142949

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000155060

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PTPRF, human

Gene expression databases

BgeeiENSG00000142949, Expressed in epithelium of mammary gland and 239 other tissues
ExpressionAtlasiH0Y7Z9, baseline and differential

Family and domain databases

CDDicd00063, FN3, 6 hits
Gene3Di2.60.40.10, 6 hits
3.90.190.10, 2 hits
InterProiView protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold
IPR029021, Prot-tyrosine_phosphatase-like
IPR000242, PTPase_domain
IPR016130, Tyr_Pase_AS
IPR003595, Tyr_Pase_cat
IPR000387, TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00041, fn3, 4 hits
PF00102, Y_phosphatase, 2 hits
PRINTSiPR00700, PRTYPHPHTASE
SMARTiView protein in SMART
SM00060, FN3, 5 hits
SM00194, PTPc, 2 hits
SM00404, PTPc_motif, 2 hits
SUPFAMiSSF49265, SSF49265, 4 hits
SSF52799, SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS50853, FN3, 6 hits
PS00383, TYR_PHOSPHATASE_1, 2 hits
PS50056, TYR_PHOSPHATASE_2, 2 hits
PS50055, TYR_PHOSPHATASE_PTP, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH0Y7Z9_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H0Y7Z9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: October 7, 2020
This is version 61 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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