UniProtKB - H0Y7Z2 (H0Y7Z2_HUMAN)
Protein
Submitted name:
Neuropilin-1
Gene
NRP1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- growth factor binding Source: InterPro
- semaphorin receptor activity Source: InterPro
- vascular endothelial growth factor-activated receptor activity Source: InterPro
GO - Biological processi
- angiogenesis Source: InterPro
- animal organ morphogenesis Source: InterPro
- axon guidance Source: InterPro
- endothelial cell chemotaxis Source: InterPro
- vascular endothelial growth factor receptor signaling pathway Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Neuropilin-1Imported |
Gene namesi | Name:NRP1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8004, NRP1 |
VEuPathDBi | HostDB:ENSG00000099250.17 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Other locations
- membrane Source: UniProtKB-SubCell
Expressioni
Gene expression databases
Bgeei | ENSG00000099250, Expressed in colon and 234 other tissues |
ExpressionAtlasi | H0Y7Z2, baseline and differential |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 24 | DisorderedSequence analysisAdd BLAST | 24 |
Phylogenomic databases
GeneTreei | ENSGT00940000157169 |
HOGENOMi | CLU_2660875_0_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR027146, NRP1 |
PANTHERi | PTHR46806:SF4, PTHR46806:SF4, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All
H0Y7Z2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
XPTAGPTTPN GNLVDECDDD QANCHSGTGD DFQLTGGTTV LATEKPTVID
60 70
STIQSARLEV STLNLSLHNP PQQKALI
Computationally mapped potential isoform sequencesi
There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO14786 | NRP1_HUMAN | Neuropilin-1 | NRP1 NRP, VEGF165R | 923 | Annotation score: | ||
E9PEP6 | E9PEP6_HUMAN | Neuropilin | NRP1 | 906 | Annotation score: | ||
Q5JWQ6 | Q5JWQ6_HUMAN | Neuropilin | NRP1 | 735 | Annotation score: | ||
Q5T7F0 | Q5T7F0_HUMAN | Neuropilin | NRP1 | 704 | Annotation score: | ||
Q5JWQ2 | Q5JWQ2_HUMAN | Neuropilin-1 | NRP1 | 105 | Annotation score: | ||
V9GYL7 | V9GYL7_HUMAN | Neuropilin-1 | NRP1 | 60 | Annotation score: | ||
H0Y4N6 | H0Y4N6_HUMAN | Neuropilin-1 | NRP1 | 100 | Annotation score: | ||
E7EX60 | E7EX60_HUMAN | Neuropilin-1 | NRP1 | 641 | Annotation score: | ||
Q5JWQ4 | Q5JWQ4_HUMAN | Neuropilin-1 | NRP1 | 597 | Annotation score: | ||
H0Y4A0 | H0Y4A0_HUMAN | Neuropilin-1 | NRP1 | 170 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL121748 Genomic DNA No translation available. AL353600 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000418675; ENSP00000416147; ENSG00000099250 |
UCSCi | uc057srd.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL121748 Genomic DNA No translation available. AL353600 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
Proteomic databases
PRIDEi | H0Y7Z2 |
ProteomicsDBi | 35546 |
Protocols and materials databases
Antibodypediai | 3859, 888 antibodies |
Genome annotation databases
Ensembli | ENST00000418675; ENSP00000416147; ENSG00000099250 |
UCSCi | uc057srd.1, human |
Organism-specific databases
HGNCi | HGNC:8004, NRP1 |
OpenTargetsi | ENSG00000099250 |
VEuPathDBi | HostDB:ENSG00000099250.17 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000157169 |
HOGENOMi | CLU_2660875_0_0_1 |
Miscellaneous databases
ChiTaRSi | NRP1, human |
Gene expression databases
Bgeei | ENSG00000099250, Expressed in colon and 234 other tissues |
ExpressionAtlasi | H0Y7Z2, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR027146, NRP1 |
PANTHERi | PTHR46806:SF4, PTHR46806:SF4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H0Y7Z2_HUMAN | |
Accessioni | H0Y7Z2Primary (citable) accession number: H0Y7Z2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 22, 2012 |
Last sequence update: | February 22, 2012 | |
Last modified: | April 7, 2021 | |
This is version 49 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |