Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Dedicator of cytokinesis protein 5

Gene

DOCK5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Dedicator of cytokinesis protein 5Imported
Gene namesi
Name:DOCK5Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000147459.17
HGNCiHGNC:23476 DOCK5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000147459

PTM / Processingi

Proteomic databases

EPDiH0Y7N4
MaxQBiH0Y7N4
PeptideAtlasiH0Y7N4
PRIDEiH0Y7N4

Expressioni

Gene expression databases

BgeeiENSG00000147459 Expressed in 199 organ(s), highest expression level in corpus callosum
ExpressionAtlasiH0Y7N4 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliH0Y7N4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini215 – 399DHR-1InterPro annotationAdd BLAST185
Domaini1003 – 1090DHR-2InterPro annotationAdd BLAST88

Sequence similaritiesi

Belongs to the DOCK family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1998 Eukaryota
ENOG410XQH7 LUCA
GeneTreeiENSGT00610000085806

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR035892 C2_domain_sf
IPR027007 DHR-1_domain
IPR027357 DHR-2
IPR026791 DOCK
IPR010703 DOCK_C
IPR032376 DOCK_N
PANTHERiPTHR23317 PTHR23317, 1 hit
PfamiView protein in Pfam
PF06920 DHR-2, 1 hit
PF14429 DOCK-C2, 1 hit
PF16172 DOCK_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51650 DHR_1, 1 hit
PS51651 DHR_2, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

H0Y7N4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XVNPAEPRFA GPVHLQYHPH LWPLCELQEL CLQHRGRCRV VYGPLRPRPV
60 70 80 90 100
HFYQDLSSMD LIRPRVSLVC QIVRVGHMEL KEGKKHTCGL RRPFGVAVMD
110 120 130 140 150
ITDIIHGKVD DEEKQHFIPF QQIAMETYIR QRQLIMSPLI TSHVIGENEP
160 170 180 190 200
LTSVLNKVIA AKEVNHKGQG LWVSLKLLPG DLTQVQKNFS HLVDRSTAIA
210 220 230 240 250
RKMGFPEIIL PGDVRNDIYV TLIHGEFDKG KKKTPKNVEV TMSVHDEEGK
260 270 280 290 300
LLEKAIHPGA GYEGISEYKS VVYYQVKQPC WYETVKVSIA IEEVTRCHIR
310 320 330 340 350
FTFRHRSSQE TRDKSERAFG VAFVKLMNPD GTTLQDGRHD LVVYKGDNKK
360 370 380 390 400
MEDAKFYLTL PGTKMEMEEK ELQASKNLVT FTPSKDSTKD SFQIATLICS
410 420 430 440 450
TKLTQNVDLL GLLNWRSNSQ NIKHNLKKLM EVDGGEIVKF LQDTLDALFN
460 470 480 490 500
IMMEMSDSET YDFLVFDALV FIISLIGDIK FQHFNPVLET YIYKHFSATL
510 520 530 540 550
AYVKLSKVLN FYVANADDSS KTELLFAALK ALKYLFRFII QSRVLYLRFY
560 570 580 590 600
GQSKDGDEFN NSIRQLFLAF NMLMDRPLEE AVKIKGAALK YLPSIINDVK
610 620 630 640 650
LVFDPVELSV LFCKFIQSIP DNQLVRQKLN CMTKIVESTL FRQSECREVL
660 670 680 690 700
LPLLTDQLSG QLDDNSNKPD HEASSQLLSN ILEVLDRKDV GATAVHIQLI
710 720 730 740 750
MERLLRRINR TVIGMNRQSP HIGSFVACMI ALLQQMDDSH YSHYISTFKT
760 770 780 790 800
RQDIIDFLME TFIMFKDLIG KNVYAKDWMV MNMTQNRVFL RAINQFAEVL
810 820 830 840 850
TRFFMDQASF ELQLWNNYFH LAVAFLTHES LQLETFSQAK RNKIVKKYGD
860 870 880 890 900
MRKEIGFRIR DMWYNLGPHK IKFIPSMVGP ILEVTLTPEV ELRKATIPIF
910 920 930 940 950
FDMMQCEFNF SGNGNFHMFE NELITKLDQE VEGGRGDEQY KVLLEKLLLE
960 970 980 990 1000
HCRKHKYLSS SGEVFALLVS SLLENLLDYR TIIMQDESKE NRMSCTVNVL
1010 1020 1030 1040 1050
NFYKEKKRED IYIRYLYKLR DLHRDCENYT EAAYTLLLHA ELLQVNGSES
1060 1070 1080 1090
LFQQGGVQCP FRLNSIHFMI LMGKNFIPGI SFYTSFFSSF
Length:1,090
Mass (Da):126,126
Last modified:February 22, 2012 - v1
Checksum:i86C4BE7E30034B15
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9H7D0DOCK5_HUMAN
Dedicator of cytokinesis protein 5
DOCK5
1,870Annotation score:
B9A015B9A015_HUMAN
Dedicator of cytokinesis protein 5
DOCK5
83Annotation score:
H0YB14H0YB14_HUMAN
Dedicator of cytokinesis protein 5
DOCK5
138Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC041005 Genomic DNA No translation available.
AC091185 Genomic DNA No translation available.
KF458713 Genomic DNA No translation available.
KF458716 Genomic DNA No translation available.
KF510313 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000444569; ENSP00000414125; ENSG00000147459
UCSCiuc064lhi.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC041005 Genomic DNA No translation available.
AC091185 Genomic DNA No translation available.
KF458713 Genomic DNA No translation available.
KF458716 Genomic DNA No translation available.
KF510313 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH0Y7N4
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiH0Y7N4
MaxQBiH0Y7N4
PeptideAtlasiH0Y7N4
PRIDEiH0Y7N4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000444569; ENSP00000414125; ENSG00000147459
UCSCiuc064lhi.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000147459.17
HGNCiHGNC:23476 DOCK5
OpenTargetsiENSG00000147459
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1998 Eukaryota
ENOG410XQH7 LUCA
GeneTreeiENSGT00610000085806

Miscellaneous databases

ChiTaRSiDOCK5 human

Gene expression databases

BgeeiENSG00000147459 Expressed in 199 organ(s), highest expression level in corpus callosum
ExpressionAtlasiH0Y7N4 baseline and differential

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR035892 C2_domain_sf
IPR027007 DHR-1_domain
IPR027357 DHR-2
IPR026791 DOCK
IPR010703 DOCK_C
IPR032376 DOCK_N
PANTHERiPTHR23317 PTHR23317, 1 hit
PfamiView protein in Pfam
PF06920 DHR-2, 1 hit
PF14429 DOCK-C2, 1 hit
PF16172 DOCK_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51650 DHR_1, 1 hit
PS51651 DHR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH0Y7N4_HUMAN
AccessioniPrimary (citable) accession number: H0Y7N4
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: November 7, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again