UniProtKB - H0Y7K5 (H0Y7K5_HUMAN)
Protein
Submitted name:
Wilms tumor protein
Gene
WT1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- nucleic acid binding Source: InterPro
GO - Biological processi
- regulation of transcription, DNA-templated Source: InterPro
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Wilms tumor proteinImported |
Gene namesi | Name:WT1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12796 WT1 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
Expressioni
Gene expression databases
Bgeei | ENSG00000184937 Expressed in 116 organ(s), highest expression level in germinal epithelium of ovary |
ExpressionAtlasi | H0Y7K5 baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 396 – 425 | C2H2-typeInterPro annotationAdd BLAST | 30 | |
Domaini | 426 – 455 | C2H2-typeInterPro annotationAdd BLAST | 30 | |
Domaini | 456 – 483 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 484 – 513 | C2H2-typeInterPro annotationAdd BLAST | 30 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 14 – 42 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 55 – 75 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 121 – 157 | DisorderedSequence analysisAdd BLAST | 37 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 14 – 32 | PolarSequence analysisAdd BLAST | 19 | |
Compositional biasi | 126 – 145 | Pro-richSequence analysisAdd BLAST | 20 |
Keywords - Domaini
Zinc-fingerPROSITE-ProRule annotationPhylogenomic databases
eggNOGi | KOG1721 Eukaryota COG5048 LUCA |
GeneTreei | ENSGT00940000156734 |
Family and domain databases
InterProi | View protein in InterPro IPR017987 Wilms_tumour IPR000976 Wilms_tumour_N IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type |
PANTHERi | PTHR23235:SF49 PTHR23235:SF49, 1 hit |
Pfami | View protein in Pfam PF02165 WT1, 2 hits PF00096 zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355 ZnF_C2H2, 4 hits |
SUPFAMi | SSF57667 SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
H0Y7K5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
LDFLLLQDPA STCVPEPASQ HTLRSGPGCL QQPEQQGVRD PGGIWAKLGA
60 70 80 90 100
AEASAERLQG RRSRGASGSE PQQMGSDVRD LNALLPAVPS LGGGGGCALP
110 120 130 140 150
VSGAAQWAPV LDFAPPGASA YGSLGGPAPP PAPPPPPPPP PHSFIKQEPS
160 170 180 190 200
WGGAEPHEEQ CLSAFTVHFS GQFTGTAGAC RYGPFGPPPP SQASSGQARM
210 220 230 240 250
FPNAPYLPSC LESQPAIRNQ GYSTVTFDGT PSYGHTPSHH AAQFPNHSFK
260 270 280 290 300
HEDPMGQQGS LGEQQYSVPP PVYGCHTPTD SCTGSQALLL RTPYSSDNLY
310 320 330 340 350
QMTSQLECMT WNQMNLGATL KGVAAGSSSS VKWTEGQSNH STGYESDNHT
360 370 380 390 400
TPILCGAQYR IHTHGVFRGI QDVRRVPGVA PTLVRSASET SEKRPFMCAY
410 420 430 440 450
PGCNKRYFKL SHLQMHSRKH TGEKPYQCDF KDCERRFSRS DQLKRHQRRH
460 470 480 490 500
TGVKPFQCKT CQRKFSRSDH LKTHTRTHTG EKPFSCRWPS CQKKFARSDE
510
LVRHHNMHQR NMTKLQLAL
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP19544 | WT1_HUMAN | Wilms tumor protein | WT1 | 449 | Annotation score: | ||
J3KNN9 | J3KNN9_HUMAN | Wilms tumor protein | WT1 | 502 | Annotation score: | ||
A0A0A0MT54 | A0A0A0MT54_HUMAN | Wilms tumor protein | WT1 | 522 | Annotation score: | ||
A0A1W2PQQ0 | A0A1W2PQQ0_HUMAN | Wilms tumor protein | WT1 | 505 | Annotation score: | ||
A0A1W2PR07 | A0A1W2PR07_HUMAN | Wilms tumor protein | WT1 | 297 | Annotation score: | ||
H0YED9 | H0YED9_HUMAN | Wilms tumor protein | WT1 | 178 | Annotation score: | ||
H0Y3F0 | H0Y3F0_HUMAN | Wilms tumor protein | WT1 | 322 | Annotation score: | ||
A0A494C0I9 | A0A494C0I9_HUMAN | Wilms tumor protein | WT1 | 43 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL049692 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000448076; ENSP00000413452; ENSG00000184937 |
UCSCi | uc058adg.1 human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL049692 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
EPDi | H0Y7K5 |
PRIDEi | H0Y7K5 |
ProteomicsDBi | 35458 |
Genome annotation databases
Ensembli | ENST00000448076; ENSP00000413452; ENSG00000184937 |
UCSCi | uc058adg.1 human |
Organism-specific databases
HGNCi | HGNC:12796 WT1 |
OpenTargetsi | ENSG00000184937 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721 Eukaryota COG5048 LUCA |
GeneTreei | ENSGT00940000156734 |
Miscellaneous databases
ChiTaRSi | WT1 human |
Gene expression databases
Bgeei | ENSG00000184937 Expressed in 116 organ(s), highest expression level in germinal epithelium of ovary |
ExpressionAtlasi | H0Y7K5 baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR017987 Wilms_tumour IPR000976 Wilms_tumour_N IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type |
PANTHERi | PTHR23235:SF49 PTHR23235:SF49, 1 hit |
Pfami | View protein in Pfam PF02165 WT1, 2 hits PF00096 zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355 ZnF_C2H2, 4 hits |
SUPFAMi | SSF57667 SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H0Y7K5_HUMAN | |
Accessioni | H0Y7K5Primary (citable) accession number: H0Y7K5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 22, 2012 |
Last sequence update: | June 5, 2019 | |
Last modified: | July 31, 2019 | |
This is version 58 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |