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Protein
Submitted name:

GTPase-activating protein and VPS9 domain-containing protein 1

Gene

GAPVD1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
GTPase-activating protein and VPS9 domain-containing protein 1Imported
Gene namesi
Name:GAPVD1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000165219.21
HGNCiHGNC:23375 GAPVD1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000165219

PTM / Processingi

Proteomic databases

MaxQBiH0Y7I9
PeptideAtlasiH0Y7I9
PRIDEiH0Y7I9

Expressioni

Gene expression databases

BgeeiENSG00000165219 Expressed in 238 organ(s), highest expression level in amniotic fluid
ExpressionAtlasiH0Y7I9 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH0Y7I9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 216Ras-GAPInterPro annotationAdd BLAST216

Phylogenomic databases

GeneTreeiENSGT00530000063341

Family and domain databases

InterProiView protein in InterPro
IPR001936 RasGAP_dom
IPR008936 Rho_GTPase_activation_prot
PfamiView protein in Pfam
PF00616 RasGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50018 RAS_GTPASE_ACTIV_2, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

H0Y7I9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XNCIMQEDES YLLQVLRYLI EFELKESDNP RRLLRRGTCA FSILFKLFSE
60 70 80 90 100
GLFSAKLFLT ATLHEPIMQL LVEDEDHLET DPNKLIERFS PSQQEKLFGE
110 120 130 140 150
KGSDRFRQKV QEMVESNEAK LVALVNKFIG YLKQNTYCFP HSLRWIVSQM
160 170 180 190 200
YKTLSCVDRL EVGEVRAMCT DLLLACFICP AVVNPEQYGI ISDAPINEVA
210 220 230 240 250
RFNLMQVGRL LQQLAMTGSE EGDPRTKSSL GKFDKSCVAA FLDVVIGGRA
260 270 280 290 300
VETPPLSSVN LLEGLSRTVV YITYSQLITL VNFMKSVMSG DQLREDRMAL
310 320 330 340 350
DNLLANLPPA KPGKSSSLEM TPYNTPQLSP ATTPANKKNR LPIATRSRSR
360 370 380 390 400
TNMLMDLHMD HEGSSQETIQ EVQPEEVLVI SLGTGPQLTP GMMSENEVLN
410 420 430 440 450
MQLSDGGQGD VPVDENKLHG KPDKTLRFSL CSDNLEGISE GPSNRSNSVS
460 470 480 490 500
SLDLEGESVS ELGAGPSGSN GVEALQLLEH EQATTQDNLD DKLRKFEIRD
510 520 530 540 550
MMGLTDDRDI SETVSETWST DVLGSDFDPN IDEDRLQEIA GAAAENMLGS
560 570 580 590 600
LLCLPGSGSV LLDPCTGSTI SETTSEAWSV EVLPSDSEAP DLKQEERLQE
610 620 630 640 650
LESCSGLGST SDDTDVREVS SRPSTPGLSV VSGISATSED IPNKIEDLRS
660 670 680 690 700
ECSSDFGGKD SVTSPDMDEI THGASAVVRP KVHYARPSHP PPDPPILEGA
710 720 730 740 750
VGGNEARLPN FGSHVLTPAE MEAFKQRHSY PERLVRSRSS DIVSSVRRPM
760 770 780 790 800
SDPSWNRRPG NEERELPPAA AIGATSLVAA PHSSSSSPSK DSSRGETEER
810 820 830
KDSDDEKSDR NRPWWRKRFV SAMPKAPIPF RKKEKQE
Length:837
Mass (Da):92,182
Last modified:February 22, 2012 - v1
Checksum:iB009C5761C75548D
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q14C86GAPD1_HUMAN
GTPase-activating protein and VPS9 ...
GAPVD1 GAPEX5, KIAA1521, RAP6
1,478Annotation score:
H0Y4E7H0Y4E7_HUMAN
GTPase-activating protein and VPS9 ...
GAPVD1
830Annotation score:
F8W9S7F8W9S7_HUMAN
GTPase-activating protein and VPS9 ...
GAPVD1
1,412Annotation score:
B0QZ65B0QZ65_HUMAN
GTPase-activating protein and VPS9 ...
GAPVD1
497Annotation score:
C9IZ08C9IZ08_HUMAN
GTPase-activating protein and VPS9 ...
GAPVD1
988Annotation score:
A0A0A0MQV8A0A0A0MQV8_HUMAN
GTPase-activating protein and VPS9 ...
GAPVD1
629Annotation score:
B4DGD8B4DGD8_HUMAN
GTPase-activating protein and VPS9 ...
GAPVD1
756Annotation score:
C9IZX9C9IZX9_HUMAN
GTPase-activating protein and VPS9 ...
GAPVD1
117Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei837Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL354710 Genomic DNA No translation available.
AL627223 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000431329; ENSP00000413082; ENSG00000165219
UCSCiuc064vrp.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL354710 Genomic DNA No translation available.
AL627223 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH0Y7I9
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiH0Y7I9
PeptideAtlasiH0Y7I9
PRIDEiH0Y7I9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000431329; ENSP00000413082; ENSG00000165219
UCSCiuc064vrp.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000165219.21
HGNCiHGNC:23375 GAPVD1
OpenTargetsiENSG00000165219
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00530000063341

Miscellaneous databases

ChiTaRSiGAPVD1 human

Gene expression databases

BgeeiENSG00000165219 Expressed in 238 organ(s), highest expression level in amniotic fluid
ExpressionAtlasiH0Y7I9 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR001936 RasGAP_dom
IPR008936 Rho_GTPase_activation_prot
PfamiView protein in Pfam
PF00616 RasGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50018 RAS_GTPASE_ACTIV_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH0Y7I9_HUMAN
AccessioniPrimary (citable) accession number: H0Y7I9
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: September 12, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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