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Protein
Submitted name:

Calpastatin

Gene

CAST

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
CalpastatinImported
Gene namesi
Name:CASTImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000153113.23
HGNCiHGNC:1515 CAST

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000153113

PTM / Processingi

Proteomic databases

MaxQBiH0Y7F0
PeptideAtlasiH0Y7F0
PRIDEiH0Y7F0

Expressioni

Gene expression databases

BgeeiENSG00000153113 Expressed in 239 organ(s), highest expression level in bronchial epithelial cell
ExpressionAtlasiH0Y7F0 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH0Y7F0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili207 – 227Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

GeneTreeiENSGT00390000002993

Family and domain databases

InterProiView protein in InterPro
IPR026998 Calpastatin
IPR001259 Prot_inh_calpain
PANTHERiPTHR10077 PTHR10077, 1 hit
PfamiView protein in Pfam
PF00748 Calpain_inhib, 3 hits

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 24 potential isoforms that are computationally mapped.Show allAlign All

H0Y7F0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XKTEKEESTE VLKAQSAGTV RSAAPPQEKK RKVEKDTMSD QALEALSASL
60 70 80 90 100
GTRQAEPELD LRSIKEVDEA KAKEEKLEKC GEDDETIPSE YRLKPATDKD
110 120 130 140 150
GKPLLPEPEE KPKPRSESEL IDELSEDFDR SECKEKPSKP TEKTEESKAA
160 170 180 190 200
APAPVSEAVC RTSMCSIQSA PPEPATLKGT VPDDAVEALA DSLGKKEADP
210 220 230 240 250
EDGKPVMDKV KEKAKEEDRE KLGEKEETIP PDYRLEEVKD KDGKPLLPKE
260 270 280 290 300
SKEQLPPMSE DFLLDALSED FSGPQNASSL KFEDAKLAAA ISEVVSQTPA
310 320 330 340 350
STTQAGAPPR DTSQSDKDLD DALDKLSDSL GQRQPDPDEN KPMEDKVKEK
360 370 380 390 400
AKAEHRDKLG ERDDTIPPEY RHLLDDNGQD KPVKPPTKKS EDSKKPADDQ
410 420 430
DPIDALSGDL DSCPSTTETS QNTAKTTEET SKPKDD
Length:436
Mass (Da):47,825
Last modified:February 22, 2012 - v1
Checksum:i7C97423591D2EB97
GO

Computationally mapped potential isoform sequencesi

There are 24 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P20810ICAL_HUMAN
Calpastatin
CAST
708Annotation score:
E9PCH5E9PCH5_HUMAN
Calpastatin
CAST
673Annotation score:
E9PDE4E9PDE4_HUMAN
Calpastatin
CAST
636Annotation score:
A0A0C4DGB5A0A0C4DGB5_HUMAN
Calpastatin
CAST
754Annotation score:
B7Z574B7Z574_HUMAN
cDNA FLJ56123, highly similar to Ca...
CAST
694Annotation score:
E7EVY3E7EVY3_HUMAN
Calpastatin
CAST
693Annotation score:
E7ES10E7ES10_HUMAN
Calpastatin
CAST
642Annotation score:
F8W7E0F8W7E0_HUMAN
Calpastatin
CAST
393Annotation score:
H0YA91H0YA91_HUMAN
Calpastatin
CAST
301Annotation score:
E7EQA0E7EQA0_HUMAN
Calpastatin
CAST
431Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008906 Genomic DNA No translation available.
AC020900 Genomic DNA No translation available.
AC104125 Genomic DNA No translation available.
KC877037 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000437034; ENSP00000412374; ENSG00000153113
UCSCiuc063fpk.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008906 Genomic DNA No translation available.
AC020900 Genomic DNA No translation available.
AC104125 Genomic DNA No translation available.
KC877037 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH0Y7F0
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiH0Y7F0
PeptideAtlasiH0Y7F0
PRIDEiH0Y7F0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000437034; ENSP00000412374; ENSG00000153113
UCSCiuc063fpk.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000153113.23
HGNCiHGNC:1515 CAST
OpenTargetsiENSG00000153113
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000002993

Miscellaneous databases

ChiTaRSiCAST human

Gene expression databases

BgeeiENSG00000153113 Expressed in 239 organ(s), highest expression level in bronchial epithelial cell
ExpressionAtlasiH0Y7F0 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR026998 Calpastatin
IPR001259 Prot_inh_calpain
PANTHERiPTHR10077 PTHR10077, 1 hit
PfamiView protein in Pfam
PF00748 Calpain_inhib, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiH0Y7F0_HUMAN
AccessioniPrimary (citable) accession number: H0Y7F0
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: September 12, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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