UniProtKB - H0Y732 (H0Y732_HUMAN)
Protein
Submitted name:
HLA class II histocompatibility antigen, DM alpha chain
Gene
HLA-DMA
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Source: UniProtKB-KW
Keywordsi
Biological process | Adaptive immunity, Immunity |
Names & Taxonomyi
Protein namesi | Submitted name: HLA class II histocompatibility antigen, DM alpha chainImported |
Gene namesi | Name:HLA-DMAImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4934, HLA-DMA |
VEuPathDBi | HostDB:ENSG00000204257.14 |
Subcellular locationi
Lysosome
- Lysosome membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Endosome
- Endosome membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Endosome
- endosome membrane Source: UniProtKB-SubCell
Lysosome
- lysosomal membrane Source: UniProtKB-SubCell
Plasma Membrane
- MHC class II protein complex Source: UniProtKB-KW
Other locations
- integral component of membrane Source: UniProtKB-KW
- intracellular membrane-bounded organelle Source: HPA
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 264 – 284 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
EndosomeARBA annotation, LysosomeARBA annotation, Membrane, MHC IIARBA annotationPTM / Processingi
Keywords - PTMi
Disulfide bondARBA annotation, GlycoproteinARBA annotationProteomic databases
PRIDEi | H0Y732 |
ProteomicsDBi | 35348 |
Expressioni
Gene expression databases
Bgeei | ENSG00000204257, Expressed in lymph node and 220 other tissues |
ExpressionAtlasi | H0Y732, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 151 – 245 | Ig-likeInterPro annotationAdd BLAST | 95 |
Sequence similaritiesi
Belongs to the MHC class II family.UniRule annotation
Keywords - Domaini
SignalARBA annotation, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000161157 |
PhylomeDBi | H0Y732 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.10.320.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011162, MHC_I/II-like_Ag-recog IPR014745, MHC_II_a/b_N IPR001003, MHC_II_a_N |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00993, MHC_II_alpha, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit SM00920, MHC_II_alpha, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 21 potential isoforms that are computationally mapped.Show allAlign All
H0Y732-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
VSCWLSDSCQ ELQRRGIILC SYGVTSPIAV FGRPGRLRNR RHFERRLVPM
60 70 80 90 100
KWLKKCLDTA PTPMWPDDLQ NHTFLHTVYC QDGSPSVGLS EAYDEDQLFF
110 120 130 140 150
FDFSQNTRVP RLPEFADWAQ EQGDAPAILF DKEFCEWMIQ QIGPKLDGKI
160 170 180 190 200
PVSRGFPIAE VFTLKPLEFG KPNTLVCFVS NLFPPMLTVN WQHHSVPVEG
210 220 230 240 250
FGPTFVSAVD GLSFQAFSYL NFTPEPSDIF SCIVTHEIDR YTAIAYWVPR
260 270 280 290
NALPSDLLEN VLCGVAFGLG VLGIIVGIVL IIYFRKPCSG
Computationally mapped potential isoform sequencesi
There are 21 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP28067 | DMA_HUMAN | HLA class II histocompatibility ant... | HLA-DMA DMA, RING6 | 261 | Annotation score: | ||
Q5SP00 | Q5SP00_HUMAN | HLA class II histocompatibility ant... | HLA-DMA | 227 | Annotation score: | ||
A0A140T9G2 | A0A140T9G2_HUMAN | HLA class II histocompatibility ant... | HLA-DMA | 227 | Annotation score: | ||
A0A140T9H8 | A0A140T9H8_HUMAN | HLA class II histocompatibility ant... | HLA-DMA | 261 | Annotation score: | ||
A0A140T9K8 | A0A140T9K8_HUMAN | HLA class II histocompatibility ant... | HLA-DMA | 290 | Annotation score: | ||
A0A140T9N9 | A0A140T9N9_HUMAN | HLA class II histocompatibility ant... | HLA-DMA | 290 | Annotation score: | ||
A0A140T9T3 | A0A140T9T3_HUMAN | HLA class II histocompatibility ant... | HLA-DMA | 290 | Annotation score: | ||
A0A140T9V7 | A0A140T9V7_HUMAN | HLA class II histocompatibility ant... | HLA-DMA | 290 | Annotation score: | ||
A0A140T9X4 | A0A140T9X4_HUMAN | HLA class II histocompatibility ant... | HLA-DMA | 290 | Annotation score: | ||
A0A140T9N7 | A0A140T9N7_HUMAN | HLA class II histocompatibility ant... | HLA-DMA | 290 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 | |
Non-terminal residuei | 290 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL645941 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000456800; ENSP00000409668; ENSG00000204257 |
UCSCi | uc063nsu.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL645941 Genomic DNA No translation available. |
3D structure databases
SMRi | H0Y732 |
ModBasei | Search... |
Proteomic databases
PRIDEi | H0Y732 |
ProteomicsDBi | 35348 |
Protocols and materials databases
Antibodypediai | 2402, 373 antibodies |
Genome annotation databases
Ensembli | ENST00000456800; ENSP00000409668; ENSG00000204257 |
UCSCi | uc063nsu.1, human |
Organism-specific databases
HGNCi | HGNC:4934, HLA-DMA |
OpenTargetsi | ENSG00000204257 |
VEuPathDBi | HostDB:ENSG00000204257.14 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000161157 |
PhylomeDBi | H0Y732 |
Miscellaneous databases
ChiTaRSi | HLA-DMA, human |
Gene expression databases
Bgeei | ENSG00000204257, Expressed in lymph node and 220 other tissues |
ExpressionAtlasi | H0Y732, baseline and differential |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.10.320.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011162, MHC_I/II-like_Ag-recog IPR014745, MHC_II_a/b_N IPR001003, MHC_II_a_N |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00993, MHC_II_alpha, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit SM00920, MHC_II_alpha, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H0Y732_HUMAN | |
Accessioni | H0Y732Primary (citable) accession number: H0Y732 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 22, 2012 |
Last sequence update: | February 22, 2012 | |
Last modified: | February 10, 2021 | |
This is version 57 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |