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Protein

DNA topoisomerase

Gene

TOP3B

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.UniRule annotation

Catalytic activityi

ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation, Isomerase, TopoisomeraseUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
DNA topoisomeraseUniRule annotation (EC:5.99.1.2UniRule annotation)
Gene namesi
Name:TOP3BImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100038.19
HGNCiHGNC:11993 TOP3B

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000100038

PTM / Processingi

Proteomic databases

MaxQBiH0Y6W0
PeptideAtlasiH0Y6W0
PRIDEiH0Y6W0

Expressioni

Gene expression databases

BgeeiENSG00000100038 Expressed in 120 organ(s), highest expression level in dorsal plus ventral thalamus
ExpressionAtlasiH0Y6W0 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH0Y6W0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini84 – 340TOP1AcInterPro annotationAdd BLAST257

Sequence similaritiesi

Belongs to the type IA topoisomerase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1956 Eukaryota
COG0550 LUCA
GeneTreeiENSGT00530000063430

Family and domain databases

CDDicd00186 TOP1Ac, 1 hit
Gene3Di1.10.290.10, 1 hit
1.10.460.10, 1 hit
2.70.20.10, 1 hit
InterProiView protein in InterPro
IPR000380 Topo_IA
IPR023406 Topo_IA_AS
IPR013497 Topo_IA_cen
IPR013824 Topo_IA_cen_sub1
IPR013825 Topo_IA_cen_sub2
IPR013826 Topo_IA_cen_sub3
IPR023405 Topo_IA_core_domain
IPR003602 Topo_IA_DNA-bd_dom
PANTHERiPTHR11390 PTHR11390, 1 hit
PfamiView protein in Pfam
PF01131 Topoisom_bac, 1 hit
PRINTSiPR00417 PRTPISMRASEI
SMARTiView protein in SMART
SM00437 TOP1Ac, 1 hit
SUPFAMiSSF56712 SSF56712, 1 hit
PROSITEiView protein in PROSITE
PS00396 TOPOISOMERASE_I_PROK, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All

H0Y6W0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XLDSSLISFG PCQTPTLGFC VERHDKIQSF KPETYWVLQA KVNTDKDRSL
60 70 80 90 100
LLDWDRVRVF DREIAQMFLN MTKLEKEAQV EATSRKEKAK QRPLALNTVE
110 120 130 140 150
MLRVASSSLG MGPQHAMQTA ERLYTQGYIS YPRTETTHYP ENFDLKGSLR
160 170 180 190 200
QQANHPYWAD TVKRLLAEGI NRPRKGHDAG DHPPITPMKS ATEAELGGDA
210 220 230 240 250
WRLYEYITRH FIATVSHDCK YLQSTISFRI GPELFTCSGK TVLSPGFTEV
260 270 280 290 300
MPWQSVPLEE SLPTCQRGDA FPVGEVKMLE KQTNPPDYLT EAELITLMEK
310 320 330 340 350
HGIGTDASIP VHINNICQRN YVTVESGRRL KPTNLGIVLV HGYYKIDAEL
360 370 380 390 400
VLPTIRSAVE KQLNLIAQGK ADYRQVLGHT LDVFKRKFHY FVDSIAGMDE
410 420 430 440 450
LMEVSFSPLA ATGKPLSRCG KCHRFMKYIQ AKPSRLHCSH CDETYTLPQN
460 470 480 490 500
GTIKLYKELR CPLDDFELVL WSSGSRGKSY PLCPYCYNHP PFRDMKKGEC
510 520
SHSLLSTGSC SLFSVPTPAL HQAGL
Length:525
Mass (Da):59,382
Last modified:February 22, 2012 - v1
Checksum:i2877E62520BC3CA0
GO

Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O95985TOP3B_HUMAN
DNA topoisomerase 3-beta-1
TOP3B TOP3B1
862Annotation score:
C9JEI7C9JEI7_HUMAN
DNA topoisomerase
TOP3B
246Annotation score:
H7C4B0H7C4B0_HUMAN
DNA topoisomerase
TOP3B
168Annotation score:
C9JKE2C9JKE2_HUMAN
DNA topoisomerase
TOP3B
121Annotation score:
C9JT00C9JT00_HUMAN
DNA topoisomerase
TOP3B
122Annotation score:
F2Z2A5F2Z2A5_HUMAN
DNA topoisomerase
TOP3B
129Annotation score:
C9J9X4C9J9X4_HUMAN
DNA topoisomerase
TOP3B
61Annotation score:
C9JTQ7C9JTQ7_HUMAN
DNA topoisomerase
TOP3B
42Annotation score:
C9JEQ1C9JEQ1_HUMAN
DNA topoisomerase
TOP3B
60Annotation score:
C9JHR0C9JHR0_HUMAN
DNA topoisomerase
TOP3B
46Annotation score:
There is more potential isoformShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC245452 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000457270; ENSP00000408282; ENSG00000100038
UCSCiuc062cal.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC245452 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH0Y6W0
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiH0Y6W0
PeptideAtlasiH0Y6W0
PRIDEiH0Y6W0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000457270; ENSP00000408282; ENSG00000100038
UCSCiuc062cal.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000100038.19
HGNCiHGNC:11993 TOP3B
OpenTargetsiENSG00000100038
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1956 Eukaryota
COG0550 LUCA
GeneTreeiENSGT00530000063430

Miscellaneous databases

ChiTaRSiTOP3B human

Gene expression databases

BgeeiENSG00000100038 Expressed in 120 organ(s), highest expression level in dorsal plus ventral thalamus
ExpressionAtlasiH0Y6W0 baseline and differential

Family and domain databases

CDDicd00186 TOP1Ac, 1 hit
Gene3Di1.10.290.10, 1 hit
1.10.460.10, 1 hit
2.70.20.10, 1 hit
InterProiView protein in InterPro
IPR000380 Topo_IA
IPR023406 Topo_IA_AS
IPR013497 Topo_IA_cen
IPR013824 Topo_IA_cen_sub1
IPR013825 Topo_IA_cen_sub2
IPR013826 Topo_IA_cen_sub3
IPR023405 Topo_IA_core_domain
IPR003602 Topo_IA_DNA-bd_dom
PANTHERiPTHR11390 PTHR11390, 1 hit
PfamiView protein in Pfam
PF01131 Topoisom_bac, 1 hit
PRINTSiPR00417 PRTPISMRASEI
SMARTiView protein in SMART
SM00437 TOP1Ac, 1 hit
SUPFAMiSSF56712 SSF56712, 1 hit
PROSITEiView protein in PROSITE
PS00396 TOPOISOMERASE_I_PROK, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH0Y6W0_HUMAN
AccessioniPrimary (citable) accession number: H0Y6W0
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: November 7, 2018
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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