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Protein
Submitted name:

Lysine-specific histone demethylase 1B

Gene

KDM1B

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri133 – 193CW-typePROSITE-ProRule annotationAdd BLAST61

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Lysine-specific histone demethylase 1BImported
Gene namesi
Name:KDM1BImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000165097.13
HGNCiHGNC:21577 KDM1B

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000165097

PTM / Processingi

Proteomic databases

EPDiH0Y6H0
MaxQBiH0Y6H0
PeptideAtlasiH0Y6H0
PRIDEiH0Y6H0

Expressioni

Gene expression databases

BgeeiENSG00000165097 Expressed in 189 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiH0Y6H0 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH0Y6H0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini133 – 193CW-typeInterPro annotationAdd BLAST61
Domaini275 – 373SWIRMInterPro annotationAdd BLAST99

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri133 – 193CW-typePROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0029 Eukaryota
ENOG410XSNC LUCA
GeneTreeiENSGT00530000062888
OMAiIKMHKLG
OrthoDBiEOG091G04NO

Family and domain databases

Gene3Di1.10.10.10, 1 hit
3.50.50.60, 1 hit
InterProiView protein in InterPro
IPR002937 Amino_oxidase
IPR036188 FAD/NAD-bd_sf
IPR009057 Homeobox-like_sf
IPR007526 SWIRM
IPR036388 WH-like_DNA-bd_sf
IPR011124 Znf_CW
PfamiView protein in Pfam
PF01593 Amino_oxidase, 1 hit
PF04433 SWIRM, 1 hit
PF07496 zf-CW, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF51905 SSF51905, 1 hit
PROSITEiView protein in PROSITE
PS50934 SWIRM, 1 hit
PS51050 ZF_CW, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

H0Y6H0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATPRGRTKK KASFDHSPDS LPLRSSGRQA KKKATETTDE DEDGGSEKKY
60 70 80 90 100
RKCEKAGCTA TCPVCFASAS ERCAKNGYTS RWYHLSCGEH FCNECFDHYY
110 120 130 140 150
RSHKDGYDKY TTWKKIWTSN GKTEPSPKAF MADQQLPYWV QCTKPECRKW
160 170 180 190 200
RQLTKEIQLT PQIAKTYRCG MKPNTAIKPE TSDHCSLPED LRVLEVSNHW
210 220 230 240 250
WYSMLILPPL LKDSVAAPLL SAYYPDCVGM SPSCTSTNRA AATGNASPGK
260 270 280 290 300
LEHSKAALSV HVPGMNRYFQ PFYQPNECGK ALCVRPDVME LDELYEFPEY
310 320 330 340 350
SRDPTMYLAL RNLILALWYT NCKEALTPQK CIPHIIVRGL VRIRCVQEVE
360 370 380 390 400
RILYFMTRKG LINTGVLSVG ADQYLLPKDY HNKSVIIIGA GPAGLAAARQ
410 420 430 440 450
LHNFGIKVTV LEAKDRIGGR VWDDKSFKGV TVGRGAQIVN GCINNPVALM
460 470 480 490 500
CEQLGISMHK FGERCDLIQE GGRITDPTID KRMDFHFNAL LDVVSEWRKD
510 520 530 540 550
KTQLQDVPLG EKIEEIYKAF IKESGIQFSE LEGQVLQFHL SNLEYACGSN
560 570 580 590 600
LHQVSARSWD HNEFFAQFAG DHTLLTPGYS VIIEKLAEGL DIQLKSPQVQ
610 620 630 640 650
CIDYSGDEVQ VTTTDGTGYS AQKVLVTVPL ALLQKGAIQF NPPLSEKKMK
660 670 680 690 700
AINSLGAGII EKIALQFPYR FWDSKVQGAD FFGHVPPSAS KRGLFAVFYD
710 720 730 740 750
MDPQKKHSVL MSVIAGEAVA SVRTLDDKQV LQQCMATLRE LFKEQEVPDP
760 770 780 790 800
TKYFVTRWST DPWIQMAYSF VKTGGSGEAY DIIAEDIQGT VFFAGEATNR
810 820
HFPQTVTGAY LSGVREASKI AAF
Length:823
Mass (Da):92,226
Last modified:June 20, 2018 - v2
Checksum:iAC1E298A27B94A6C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8NB78KDM1B_HUMAN
Lysine-specific histone demethylase...
KDM1B AOF1, C6orf193, LSD2
822Annotation score:
Q08EI0Q08EI0_HUMAN
AOF1 protein
KDM1B AOF1
113Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031774 Genomic DNA No translation available.
AL589723 Genomic DNA No translation available.
RefSeqiXP_005248982.1, XM_005248925.1
UniGeneiHs.709336

Genome annotation databases

EnsembliENST00000449850; ENSP00000405669; ENSG00000165097
GeneIDi221656
UCSCiuc063mbp.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031774 Genomic DNA No translation available.
AL589723 Genomic DNA No translation available.
RefSeqiXP_005248982.1, XM_005248925.1
UniGeneiHs.709336

3D structure databases

ProteinModelPortaliH0Y6H0
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiH0Y6H0
MaxQBiH0Y6H0
PeptideAtlasiH0Y6H0
PRIDEiH0Y6H0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000449850; ENSP00000405669; ENSG00000165097
GeneIDi221656
UCSCiuc063mbp.1 human

Organism-specific databases

CTDi221656
EuPathDBiHostDB:ENSG00000165097.13
HGNCiHGNC:21577 KDM1B
OpenTargetsiENSG00000165097
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0029 Eukaryota
ENOG410XSNC LUCA
GeneTreeiENSGT00530000062888
OMAiIKMHKLG
OrthoDBiEOG091G04NO

Miscellaneous databases

ChiTaRSiKDM1B human

Gene expression databases

BgeeiENSG00000165097 Expressed in 189 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiH0Y6H0 baseline and differential

Family and domain databases

Gene3Di1.10.10.10, 1 hit
3.50.50.60, 1 hit
InterProiView protein in InterPro
IPR002937 Amino_oxidase
IPR036188 FAD/NAD-bd_sf
IPR009057 Homeobox-like_sf
IPR007526 SWIRM
IPR036388 WH-like_DNA-bd_sf
IPR011124 Znf_CW
PfamiView protein in Pfam
PF01593 Amino_oxidase, 1 hit
PF04433 SWIRM, 1 hit
PF07496 zf-CW, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF51905 SSF51905, 1 hit
PROSITEiView protein in PROSITE
PS50934 SWIRM, 1 hit
PS51050 ZF_CW, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH0Y6H0_HUMAN
AccessioniPrimary (citable) accession number: H0Y6H0
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: June 20, 2018
Last modified: November 7, 2018
This is version 58 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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