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Protein
Submitted name:

Alsin

Gene

ALS2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
AlsinImported
Gene namesi
Name:ALS2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000003393.14
HGNCiHGNC:443 ALS2

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000003393

PTM / Processingi

Proteomic databases

EPDiH0Y696
MaxQBiH0Y696
PeptideAtlasiH0Y696
PRIDEiH0Y696

Expressioni

Gene expression databases

BgeeiENSG00000003393 Expressed in 192 organ(s), highest expression level in cerebellum
ExpressionAtlasiH0Y696 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliH0Y696
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 206DHInterPro annotationAdd BLAST196

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili133 – 153Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation

Phylogenomic databases

eggNOGiKOG0231 Eukaryota
KOG1426 Eukaryota
COG4642 LUCA
GeneTreeiENSGT00730000110297

Family and domain databases

Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR003409 MORN
IPR011993 PH-like_dom_sf
PfamiView protein in Pfam
PF02493 MORN, 7 hits
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00698 MORN, 7 hits
SUPFAMiSSF48065 SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

H0Y696-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XLALVDKNIM GYIASLHELA TTERRFYSKL SDIKSQILRP LLSLENLGTT
60 70 80 90 100
TTVQLLQEVA SRFSKLCYLI GQHGASLSSF LHGVKEARSL VILKHSSLFL
110 120 130 140 150
DSYTEYCTSI TNFLVMGGFQ LLAKPAIDFL NKNQELLQDL SEVNDENTQL
160 170 180 190 200
MEILNTLFFL PIRRLHNYAK VLLKLATCFE VASPEYQKLQ DSSSCYECLA
210 220 230 240 250
LHLGRKRKEA EYTLGFWKTF PGKMTDSLRK PERRLLCESS NRALSLQHAG
260 270 280 290 300
RFSVNWFILF NDALVHAQFS THHVFPLATL WAEPLSEEAG GVNGLKITTP
310 320 330 340 350
EEQFTLISST PQEKTKWLRA ISQAVDQALR GMSDLPPYGS GSSVQRQEPP
360 370 380 390 400
ISRSAKYTFY KDPRLKDATY DGRWLSGKPH GRGVLKWPDG KMYSGMFRNG
410 420 430 440 450
LEDGYGEYRI PNKAMNKEDH YVGHWKEGKM CGQGVYSYAS GEVFEGCFQD
460 470 480 490 500
NMRHGHGLLR SGKLTSSSPS MFIGQWVMDK KAGYGVFDDI TRGEKYMGMW
510 520 530 540 550
QDDVCQGNGV VVTQFGLYYE GNFHLNKMMG NGVLLSEDDT IYEGEFSDDW
560 570 580
TLSGKDNSGL IEQVGKCSLL PYFLKVCEAL VLFLL
Length:585
Mass (Da):66,051
Last modified:February 22, 2012 - v1
Checksum:i66030590A195FF4C
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q96Q42ALS2_HUMAN
Alsin
ALS2 ALS2CR6, KIAA1563
1,657Annotation score:
J3KQ33J3KQ33_HUMAN
Alsin
ALS2
139Annotation score:
J3KQ43J3KQ43_HUMAN
Alsin
ALS2
106Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007242 Genomic DNA No translation available.
AC007279 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000439495; ENSP00000403832; ENSG00000003393
UCSCiuc061rlq.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007242 Genomic DNA No translation available.
AC007279 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH0Y696
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiH0Y696
MaxQBiH0Y696
PeptideAtlasiH0Y696
PRIDEiH0Y696

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000439495; ENSP00000403832; ENSG00000003393
UCSCiuc061rlq.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000003393.14
HGNCiHGNC:443 ALS2
OpenTargetsiENSG00000003393
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0231 Eukaryota
KOG1426 Eukaryota
COG4642 LUCA
GeneTreeiENSGT00730000110297

Miscellaneous databases

ChiTaRSiALS2 human

Gene expression databases

BgeeiENSG00000003393 Expressed in 192 organ(s), highest expression level in cerebellum
ExpressionAtlasiH0Y696 baseline and differential

Family and domain databases

Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR003409 MORN
IPR011993 PH-like_dom_sf
PfamiView protein in Pfam
PF02493 MORN, 7 hits
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00698 MORN, 7 hits
SUPFAMiSSF48065 SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH0Y696_HUMAN
AccessioniPrimary (citable) accession number: H0Y696
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: September 12, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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