UniProtKB - H0Y663 (H0Y663_HUMAN)
Protein
Protein Wnt
Gene
WNT4
Organism
Homo sapiens (Human)
Status
Functioni
Ligand for members of the frizzled family of seven transmembrane receptors.UniRule annotation
GO - Molecular functioni
- signaling receptor binding Source: InterPro
GO - Biological processi
- multicellular organism development Source: UniProtKB-KW
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental proteinUniRule annotationARBA annotation |
Biological process | Wnt signaling pathwayUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Protein WntUniRule annotation |
Gene namesi | Name:WNT4Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000162552.14 |
HGNCi | HGNC:12783, WNT4 |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix UniRule annotationARBA annotation
Extracellular region or secreted
- extracellular region Source: UniProtKB-KW
Keywords - Cellular componenti
Extracellular matrixARBA annotation, SecretedPTM / Processingi
Keywords - PTMi
Disulfide bondARBA annotation, GlycoproteinARBA annotation, LipoproteinARBA annotationProteomic databases
PeptideAtlasi | H0Y663 |
PRIDEi | H0Y663 |
ProteomicsDBi | 35137 |
Expressioni
Gene expression databases
Bgeei | ENSG00000162552, Expressed in decidua and 132 other tissues |
ExpressionAtlasi | H0Y663, baseline and differential |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 126 – 150 | DisorderedSequence analysisAdd BLAST | 25 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 136 – 150 | PolarSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Keywords - Domaini
SignalARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000159654 |
HOGENOMi | CLU_1839696_0_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR005817, Wnt IPR009142, Wnt4 |
PANTHERi | PTHR12027, PTHR12027, 1 hit |
Pfami | View protein in Pfam PF00110, wnt, 1 hit |
PRINTSi | PR01844, WNT4PROTEIN |
SMARTi | View protein in SMART SM00097, WNT1, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
H0Y663-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
XYLAKLSSVG SISEEETCEK LKGLIQRQVQ MCKRNLEVMD SVRRGAQLAI
60 70 80 90 100
EECQYQFRNR RWNCSTLDSL PVFGKVVTQG GKAWHGGDSG CHLLTESRSG
110 120 130 140 150
ERTQRRKEGG SLGQCWPEAI VGTQDPMRSP PYLWGRNQGG THTGSASEGH
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP56705 | WNT4_HUMAN | Protein Wnt-4 | WNT4 UNQ426/PRO864 | 351 | Annotation score: | ||
B1AJZ6 | B1AJZ6_HUMAN | Protein Wnt | WNT4 | 52 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL031281 Genomic DNA No translation available. AL445253 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000415567; ENSP00000403334; ENSG00000162552 |
UCSCi | uc057ddq.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL031281 Genomic DNA No translation available. AL445253 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | H0Y663 |
PRIDEi | H0Y663 |
ProteomicsDBi | 35137 |
Protocols and materials databases
Antibodypediai | 2555, 468 antibodies |
Genome annotation databases
Ensembli | ENST00000415567; ENSP00000403334; ENSG00000162552 |
UCSCi | uc057ddq.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000162552.14 |
HGNCi | HGNC:12783, WNT4 |
OpenTargetsi | ENSG00000162552 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000159654 |
HOGENOMi | CLU_1839696_0_0_1 |
Miscellaneous databases
ChiTaRSi | WNT4, human |
Gene expression databases
Bgeei | ENSG00000162552, Expressed in decidua and 132 other tissues |
ExpressionAtlasi | H0Y663, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR005817, Wnt IPR009142, Wnt4 |
PANTHERi | PTHR12027, PTHR12027, 1 hit |
Pfami | View protein in Pfam PF00110, wnt, 1 hit |
PRINTSi | PR01844, WNT4PROTEIN |
SMARTi | View protein in SMART SM00097, WNT1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H0Y663_HUMAN | |
Accessioni | H0Y663Primary (citable) accession number: H0Y663 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 22, 2012 |
Last sequence update: | February 22, 2012 | |
Last modified: | August 12, 2020 | |
This is version 48 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |