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Protein
Submitted name:

Msx2-interacting protein

Gene

SPEN

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionRNA-bindingPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Msx2-interacting proteinImported
Gene namesi
Name:SPENImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000065526.10
HGNCiHGNC:17575 SPEN

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000065526

PTM / Processingi

Proteomic databases

MaxQBiH0Y5U7
PeptideAtlasiH0Y5U7
PRIDEiH0Y5U7

Expressioni

Gene expression databases

BgeeiENSG00000065526 Expressed in 234 organ(s), highest expression level in vagina
ExpressionAtlasiH0Y5U7 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH0Y5U7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini75 – 148RRMInterPro annotationAdd BLAST74
Domaini178 – 253RRMInterPro annotationAdd BLAST76

Phylogenomic databases

eggNOGiKOG0112 Eukaryota
ENOG410XSAC LUCA
GeneTreeiENSGT00530000063730

Family and domain databases

CDDicd12349 RRM2_SHARP, 1 hit
cd12350 RRM3_SHARP, 1 hit
Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034173 SHARP_RRM2
IPR034174 SHARP_RRM3
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

H0Y5U7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XQASRPTRSP SGSGSRSRSS SSDSISSSSS TSSDSDSSSS SSDDSPARSV
60 70 80 90 100
QSAAVPAPTS QLLSSLEKDE PRKSFGIKVQ NLPVRSTDTS LKDGLFHEFK
110 120 130 140 150
KFGKVTSVQI HGTSEERYGL VFFRQQEDQE KALTASKGKL FFGMQIEVTA
160 170 180 190 200
WIGPETESEN EFRPLDERID EFHPKATRTL FIGNLEKTTT YHDLRNIFQR
210 220 230 240 250
FGEIVDIDIK KVNGVPQYAF LQYCDIASVC KAIKKMDGEY LGNNRLKLGF
260 270 280 290
GKSMPTNCVW LDGLSSNVSD QYLTRHFCRY GPVVKVVFDR LKGMALV
Length:297
Mass (Da):32,981
Last modified:February 22, 2012 - v1
Checksum:iB20D907BE161D141
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q96T58MINT_HUMAN
Msx2-interacting protein
SPEN KIAA0929, MINT, SHARP
3,664Annotation score:
F6WRY4F6WRY4_HUMAN
Msx2-interacting protein
SPEN
373Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei297Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL034555 Genomic DNA No translation available.
AL450998 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000442985; ENSP00000400914; ENSG00000065526
UCSCiuc057cpk.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL034555 Genomic DNA No translation available.
AL450998 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH0Y5U7
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiH0Y5U7
PeptideAtlasiH0Y5U7
PRIDEiH0Y5U7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000442985; ENSP00000400914; ENSG00000065526
UCSCiuc057cpk.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000065526.10
HGNCiHGNC:17575 SPEN
OpenTargetsiENSG00000065526
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0112 Eukaryota
ENOG410XSAC LUCA
GeneTreeiENSGT00530000063730

Miscellaneous databases

ChiTaRSiSPEN human

Gene expression databases

BgeeiENSG00000065526 Expressed in 234 organ(s), highest expression level in vagina
ExpressionAtlasiH0Y5U7 baseline and differential

Family and domain databases

CDDicd12349 RRM2_SHARP, 1 hit
cd12350 RRM3_SHARP, 1 hit
Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034173 SHARP_RRM2
IPR034174 SHARP_RRM3
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiH0Y5U7_HUMAN
AccessioniPrimary (citable) accession number: H0Y5U7
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: September 12, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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