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Entry version 59 (31 Jul 2019)
Sequence version 2 (27 May 2015)
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Protein
Submitted name:

CLIP-associating protein 1

Gene

CLASP1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
CLIP-associating protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CLASP1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17088 CLASP1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000074054

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
H0Y5T1

PeptideAtlas

More...
PeptideAtlasi
H0Y5T1

PRoteomics IDEntifications database

More...
PRIDEi
H0Y5T1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
35052

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000074054 Expressed in 235 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
H0Y5T1 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini100 – 332TOGInterPro annotationAdd BLAST233
Domaini1026 – 1264TOGInterPro annotationAdd BLAST239

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 72DisorderedSequence analysisAdd BLAST72
Regioni324 – 381DisorderedSequence analysisAdd BLAST58
Regioni395 – 530DisorderedSequence analysisAdd BLAST136
Regioni856 – 906DisorderedSequence analysisAdd BLAST51
Regioni940 – 975DisorderedSequence analysisAdd BLAST36
Regioni987 – 1006DisorderedSequence analysisAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1045 – 1065Sequence analysisAdd BLAST21
Coiled coili1127 – 1147Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 18PolarSequence analysisAdd BLAST18
Compositional biasi31 – 69PolarSequence analysisAdd BLAST39
Compositional biasi420 – 472PolarSequence analysisAdd BLAST53
Compositional biasi487 – 512PolarSequence analysisAdd BLAST26

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154817

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR028399 CLASP_1
IPR024395 CLASP_N_dom
IPR034085 TOG

The PANTHER Classification System

More...
PANTHERi
PTHR21567:SF28 PTHR21567:SF28, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12348 CLASP_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01349 TOG, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

H0Y5T1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XTKFDEVQKS GNMIQSANDK NFDDEDSVDG NRPSSASSTS SKAPPSSRRN
60 70 80 90 100
VGMGTTRRLG SSTLGSKSSA AKEGAGAVDE EDFIKAFDDV PVVQIYSSRD
110 120 130 140 150
LEESINKIRE ILSDDKHDWE QRVNALKKIR SLLLAGAAEY DNFFQHLRLL
160 170 180 190 200
DGAFKLSAKD LRSQVVREAC ITLGHLSSVL GNKFDHGAEA IMPTIFNLIP
210 220 230 240 250
NSAKIMATSG VVAVRLIIRH THIPRLIPVI TSNCTSKSVA VRRRCFEFLD
260 270 280 290 300
LLLQEWQTHS LERHISVLAE TIKKGIHDAD SEARIEARKC YWGFHSHFSR
310 320 330 340 350
EAEHLYHTLE SSYQKALQSH LKNSDSIVSL PQSDRSSSSS QESLNRPLSA
360 370 380 390 400
KRSPTGSTTS RASTVSTKSV STTGSLQRSR SDIDVNAAAS AKSKVSSSSG
410 420 430 440 450
TTPFSSAAAL PPGSYASLGR IRTRRQSSGS ATNVASTPDN RGRSRAKVVS
460 470 480 490 500
QSQRSRSANP AGAGSRSSSP GKLLGSGYGG LTGGSSRGPP VTPSSEKRSK
510 520 530 540 550
IPRSQGCSRE TSPNRIGLDR FGLGQPGRIP GSVNAMRVLS TSTDLEAAVA
560 570 580 590 600
DALLLGDSRS KKKPVRRRYE PYGMYSDDDA NSDASSVCSE RSYGSRNGGI
610 620 630 640 650
PHYLRQTEDV AEVLNHCASS NWSERKEGLL GLQNLLKSQR TLSRVELKRL
660 670 680 690 700
CEIFTRMFAD PHSKIADSEA ECEDKEGNLF PSEVSCTRVF SMFLETLVDF
710 720 730 740 750
IIIHKDDLQD WLFVLLTQLL KKMGADLLGS VQAKVQKALD VTRDSFPFDQ
760 770 780 790 800
QFNILMRFIV DQTQTPNLKV KVAILKYIES LARQMDPTDF VNSSETRLAV
810 820 830 840 850
SRIITWTTEP KSSDVRKAAQ IVLISLFELN TPEFTMLLGA LPKTFQDGAT
860 870 880 890 900
KLLHNHLKNS SNTSVGSPSN TIGRTPSRHT SSRTSPLTSP TNCSHGGLSP
910 920 930 940 950
SMLDYDTENL NSEEIYSSLR GVTEAIEKFS FRSQEDLNEP IKRDGKKECD
960 970 980 990 1000
IVSRDGGAAS PATEGRGGSE VEGGRTALDN KTSLLNTQPP RAFPGPRARD
1010 1020 1030 1040 1050
YNPYPYSDAI NTYDKTALKE AVFDDDMEQL RDVPIDHSDL VADLLKELSN
1060 1070 1080 1090 1100
HNERVEERKG ALLELLKITR EDSLGVWEEH FKTILLLLLE TLGDKDHSIR
1110 1120 1130 1140 1150
ALALRVLREI LRNQPARFKN YAELTIMKTL EAHKDSHKEV VRAAEEAAST
1160 1170 1180 1190 1200
LASSIHPEQC IKVLCPIIQT ADYPINLAAI KMQTKVVERI AKESLLQLLV
1210 1220 1230 1240 1250
DIIPGLLQGY DNTESSVRKA SVFCLVAIYS VIGEDLKPHL AQLTGSKMKL
1260 1270
LNLYIKRAQT TNSNSSSSSD VSTHS
Length:1,275
Mass (Da):140,047
Last modified:May 27, 2015 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8B3D0CFE14B8B73E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7Z460CLAP1_HUMAN
CLIP-associating protein 1
CLASP1 KIAA0622, MAST1
1,538Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WA11F8WA11_HUMAN
CLIP-associating protein 1
CLASP1
1,478Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JP76C9JP76_HUMAN
CLIP-associating protein 1
CLASP1
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J151C9J151_HUMAN
CLIP-associating protein 1
CLASP1
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC012447 Genomic DNA No translation available.
AC013399 Genomic DNA No translation available.
AC018737 Genomic DNA No translation available.
AC079449 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000452274; ENSP00000400562; ENSG00000074054

UCSC genome browser

More...
UCSCi
uc061nlj.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012447 Genomic DNA No translation available.
AC013399 Genomic DNA No translation available.
AC018737 Genomic DNA No translation available.
AC079449 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Proteomic databases

jPOSTiH0Y5T1
PeptideAtlasiH0Y5T1
PRIDEiH0Y5T1
ProteomicsDBi35052

Genome annotation databases

EnsembliENST00000452274; ENSP00000400562; ENSG00000074054
UCSCiuc061nlj.1 human

Organism-specific databases

HGNCiHGNC:17088 CLASP1
OpenTargetsiENSG00000074054

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000154817

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CLASP1 human

Gene expression databases

BgeeiENSG00000074054 Expressed in 235 organ(s), highest expression level in corpus callosum
ExpressionAtlasiH0Y5T1 baseline and differential

Family and domain databases

Gene3Di1.25.10.10, 4 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR028399 CLASP_1
IPR024395 CLASP_N_dom
IPR034085 TOG
PANTHERiPTHR21567:SF28 PTHR21567:SF28, 3 hits
PfamiView protein in Pfam
PF12348 CLASP_N, 1 hit
SMARTiView protein in SMART
SM01349 TOG, 2 hits
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH0Y5T1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H0Y5T1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: May 27, 2015
Last modified: July 31, 2019
This is version 59 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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