UniProtKB - H0Y5G9 (H0Y5G9_HUMAN)
Protein
Submitted name:
Nardilysin
Gene
NRDC
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- metal ion binding Source: InterPro
- metallopeptidase activity Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase, MetalloproteaseARBA annotation, Protease |
Ligand | ZincARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: NardilysinImported |
Gene namesi | Name:NRDCImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7995, NRDC |
VEuPathDBi | HostDB:ENSG00000078618.19 |
PTM / Processingi
Proteomic databases
MaxQBi | H0Y5G9 |
PeptideAtlasi | H0Y5G9 |
PRIDEi | H0Y5G9 |
ProteomicsDBi | 34980 |
Expressioni
Gene expression databases
Bgeei | ENSG00000078618, Expressed in quadriceps femoris and 244 other tissues |
ExpressionAtlasi | H0Y5G9, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 119 | Peptidase_M16_MInterPro annotationAdd BLAST | 112 | |
Domaini | 254 – 377 | Peptidase_M16_CInterPro annotationAdd BLAST | 124 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 379 – 399 | Sequence analysisAdd BLAST | 21 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000155026 |
HOGENOMi | CLU_004639_5_1_1 |
Family and domain databases
InterProi | View protein in InterPro IPR011249, Metalloenz_LuxS/M16 IPR007863, Peptidase_M16_C IPR032632, Peptidase_M16_M |
Pfami | View protein in Pfam PF05193, Peptidase_M16_C, 1 hit PF16187, Peptidase_M16_M, 1 hit |
SUPFAMi | SSF63411, SSF63411, 3 hits |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
H0Y5G9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
XKIEDNEFHY QEQTDPVEYV ENMCENMQLY PLQDILTGDQ LLFEYKPEVI
60 70 80 90 100
GEALNQLVPQ KANLVLLSGA NEGKCDLKEK WFGTQYSIED IENSWAELWN
110 120 130 140 150
SNFELNPDLH LPAENKYIAY IRFHLISPLI QKSAANVVLF DIFVNILTHN
160 170 180 190 200
LAEPAYEADV AQLEYKLVAG EHGLIIRVKG FNHKLPLLFQ LIIDYLAEFN
210 220 230 240 250
STPAVFTMIT EQLKKTYFNI LIKPETLAKD VRLLILEYAR WSMIDKYQAL
260 270 280 290 300
MDGLSLESLL SFVKEFKSQL FVEGLVQGNV TSTESMDFLK YVVDKLNFKP
310 320 330 340 350
LEQEMPVQFQ VVELPSGHHL CKVKALNKGD ANSEVTVYYQ SGTRSLREYT
360 370 380 390 400
LMELLVMHME EPCFDFLRTK QTLGSEVVDK KIEEFLSSFE EKIENLTEEA
410 420 430 440 450
FNTQVTALIK LKECEDTHLG EEVDRNWNEV VTQQYLFDRL AHEIEALKSF
460 470 480 490 500
SKSDLVNWFK AHRGPGSKML SVHVVGYGKY ELEEDGTPSS EDSNSSCEVM
510 520 530
QLTYLPTSPL LADCIIPITD IRAFTTTLNL LPYHKIVK
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO43847 | NRDC_HUMAN | Nardilysin | NRDC NRD1 | 1,151 | Annotation score: | ||
G3V1R5 | G3V1R5_HUMAN | Nardilysin | NRDC NRD1, hCG_40292 | 1,087 | Annotation score: | ||
F5H7V1 | F5H7V1_HUMAN | Nardilysin | NRDC | 949 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL050343 Genomic DNA No translation available. AL589663 Genomic DNA No translation available. KF495940 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000440943; ENSP00000398464; ENSG00000078618 |
UCSCi | uc057gml.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL050343 Genomic DNA No translation available. AL589663 Genomic DNA No translation available. KF495940 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
Proteomic databases
MaxQBi | H0Y5G9 |
PeptideAtlasi | H0Y5G9 |
PRIDEi | H0Y5G9 |
ProteomicsDBi | 34980 |
Protocols and materials databases
Antibodypediai | 19043, 140 antibodies |
Genome annotation databases
Ensembli | ENST00000440943; ENSP00000398464; ENSG00000078618 |
UCSCi | uc057gml.1, human |
Organism-specific databases
HGNCi | HGNC:7995, NRDC |
OpenTargetsi | ENSG00000078618 |
VEuPathDBi | HostDB:ENSG00000078618.19 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155026 |
HOGENOMi | CLU_004639_5_1_1 |
Miscellaneous databases
ChiTaRSi | NRDC, human |
Gene expression databases
Bgeei | ENSG00000078618, Expressed in quadriceps femoris and 244 other tissues |
ExpressionAtlasi | H0Y5G9, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR011249, Metalloenz_LuxS/M16 IPR007863, Peptidase_M16_C IPR032632, Peptidase_M16_M |
Pfami | View protein in Pfam PF05193, Peptidase_M16_C, 1 hit PF16187, Peptidase_M16_M, 1 hit |
SUPFAMi | SSF63411, SSF63411, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H0Y5G9_HUMAN | |
Accessioni | H0Y5G9Primary (citable) accession number: H0Y5G9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 22, 2012 |
Last sequence update: | February 22, 2012 | |
Last modified: | February 10, 2021 | |
This is version 59 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |