UniProtKB - H0Y5B5 (H0Y5B5_HUMAN)
Protein
Submitted name:
Protein polybromo-1
Gene
PBRM1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- chromatin binding Source: InterPro
GO - Biological processi
- chromatin remodeling Source: InterPro
Keywordsi
Biological process | Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Protein polybromo-1Imported |
Gene namesi | Name:PBRM1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30064, PBRM1 |
VEuPathDBi | HostDB:ENSG00000163939.18 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Nucleus
- nucleoplasm Source: HPA
- RSC-type complex Source: InterPro
PTM / Processingi
Proteomic databases
MaxQBi | H0Y5B5 |
PeptideAtlasi | H0Y5B5 |
PRIDEi | H0Y5B5 |
ProteomicsDBi | 34947 |
Expressioni
Gene expression databases
Bgeei | ENSG00000163939, Expressed in forebrain and 247 other tissues |
ExpressionAtlasi | H0Y5B5, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 78 | BromoInterPro annotationAdd BLAST | 71 | |
Domaini | 144 – 214 | BromoInterPro annotationAdd BLAST | 71 | |
Domaini | 344 – 414 | BromoInterPro annotationAdd BLAST | 71 | |
Domaini | 497 – 567 | BromoInterPro annotationAdd BLAST | 71 | |
Domaini | 635 – 705 | BromoInterPro annotationAdd BLAST | 71 | |
Domaini | 776 – 821 | BromoInterPro annotationAdd BLAST | 46 | |
Domaini | 914 – 1032 | BAHInterPro annotationAdd BLAST | 119 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 99 – 121 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 431 – 466 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 584 – 605 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 861 – 899 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 1064 – 1085 | DisorderedSequence analysisAdd BLAST | 22 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 584 – 598 | PolyampholyteSequence analysisAdd BLAST | 15 | |
Compositional biasi | 861 – 891 | PolyampholyteSequence analysisAdd BLAST | 31 |
Keywords - Domaini
BromodomainPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00390000003017 |
Family and domain databases
CDDi | cd05515, Bromo_polybromo_V, 1 hit |
Gene3Di | 1.20.920.10, 6 hits 2.30.30.490, 1 hit |
InterProi | View protein in InterPro IPR001025, BAH_dom IPR043151, BAH_sf IPR001487, Bromodomain IPR036427, Bromodomain-like_sf IPR018359, Bromodomain_CS IPR037968, PBRM1_BD5 IPR037382, Rsc/polybromo |
PANTHERi | PTHR16062, PTHR16062, 2 hits |
Pfami | View protein in Pfam PF01426, BAH, 1 hit PF00439, Bromodomain, 6 hits |
PRINTSi | PR00503, BROMODOMAIN |
SMARTi | View protein in SMART SM00439, BAH, 1 hit SM00297, BROMO, 6 hits |
SUPFAMi | SSF47370, SSF47370, 6 hits |
PROSITEi | View protein in PROSITE PS51038, BAH, 1 hit PS00633, BROMODOMAIN_1, 5 hits PS50014, BROMODOMAIN_2, 6 hits |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
H0Y5B5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
IRDYKDEQGR LLCELFIRAP KRRNQPDYYE VVSQPIDLMK IQQKLKMEEY
60 70 80 90 100
DDVNLLTADF QLLFNNAKSY YKPDSPEYKA ACKLWDLYLR TRNEFVQKGE
110 120 130 140 150
ADDEDDDEDG QDNQGTVTEG SSPAYLKEIL EQLLEAIVVA TNPSGRLISE
160 170 180 190 200
LFQKLPSKVQ YPDYYAIIKE PIDLKTIAQR IQNGSYKSIH AMAKDIDLLA
210 220 230 240 250
KNAKTYNEPG SQVFKDANSI KKIFYMKKAE IEHHEMAKSS LRMRTPSNLA
260 270 280 290 300
AARLTGPSHS KGSLGEERNP TSKYYRNKRA VQGGRLSAIT MALQYGSESE
310 320 330 340 350
EDAALAAARY EEGESEAESI TSFMDVSNPF YQLYDTVRSC RNNQGQLIAE
360 370 380 390 400
PFYHLPSKKK YPDYYQQIKM PISLQQIRTK LKNQEYETLD HLECDLNLMF
410 420 430 440 450
ENAKRYNVPN SAIYKRVLKL QQVMQAKKKE LARRDDIEDG DSMISSATSD
460 470 480 490 500
TGSAKRKRNT HDSEMLGLRR LSSKKNIRKQ RMKILFNVVL EAREPGSGRR
510 520 530 540 550
LCDLFMVKPS KKDYPDYYKI ILEPMDLKII EHNIRNDKYA GEEGMIEDMK
560 570 580 590 600
LMFRNARHYN EEGSQVYNDA HILEKLLKEK RKELGPLPDD DDMASPKLKL
610 620 630 640 650
SRKSGISPKK SKYMTPMQQK LNEVYEAVKN YTDKRGRRLS AIFLRLPSRS
660 670 680 690 700
ELPDYYLTIK KPMDMEKIRS HMMANKYQDI DSMVEDFVMM FNNACTYNEP
710 720 730 740 750
ESLIYKDALV LHKVLLETRR DLEGDEDSHV PNVTLLIQEL IHNLFVSVMS
760 770 780 790 800
HQDDEGRCYS DSLAEIPAVD PNFPNKPPLT FDIIRKNVEN NRYRRLDLFQ
810 820 830 840 850
EHMFEVLERA RRMNRTDSEI YEDAVELQQF FIKIRDELCK NGEILLSPAL
860 870 880 890 900
SYTTKHLHND VEKERKEKLP KEIEEDKLKR EEEKRAEKSE DSSGAAGLSG
910 920 930 940 950
LHRTYSQDCS FKNSMYHVGD YVYVEPAEAN LQPHIVCIER LWEDSAGEKW
960 970 980 990 1000
LYGCWFYRPN ETFHLATRKF LEKEVFKSDY YNKVPVSKIL GKCVVMFVKE
1010 1020 1030 1040 1050
YFKLCPENFR DEDVFVCESR YSAKTKSFKK IKLWTMPISS VRFVPRDVPL
1060 1070 1080
PVVRVASVFA NADKGDDEKN TDNSEDSRAE DNFNL
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ86U86 | PB1_HUMAN | Protein polybromo-1 | PBRM1 BAF180, PB1 | 1,689 | Annotation score: | ||
E7EVG2 | E7EVG2_HUMAN | Protein polybromo-1 | PBRM1 | 1,460 | Annotation score: | ||
C9JPI5 | C9JPI5_HUMAN | Protein polybromo-1 | PBRM1 | 230 | Annotation score: | ||
C9J053 | C9J053_HUMAN | Protein polybromo-1 | PBRM1 | 118 | Annotation score: | ||
C9JQF1 | C9JQF1_HUMAN | Protein polybromo-1 | PBRM1 | 152 | Annotation score: | ||
C9JCJ2 | C9JCJ2_HUMAN | Protein polybromo-1 | PBRM1 | 87 | Annotation score: | ||
C9J409 | C9J409_HUMAN | Protein polybromo-1 | PBRM1 | 43 | Annotation score: | ||
C9J9L6 | C9J9L6_HUMAN | Protein polybromo-1 | PBRM1 | 26 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 | |
Non-terminal residuei | 1085 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC104446 Genomic DNA No translation available. AC112215 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000446103; ENSP00000397662; ENSG00000163939 |
UCSCi | uc062knx.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC104446 Genomic DNA No translation available. AC112215 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | H0Y5B5 |
PeptideAtlasi | H0Y5B5 |
PRIDEi | H0Y5B5 |
ProteomicsDBi | 34947 |
Protocols and materials databases
Antibodypediai | 2905, 164 antibodies |
Genome annotation databases
Ensembli | ENST00000446103; ENSP00000397662; ENSG00000163939 |
UCSCi | uc062knx.1, human |
Organism-specific databases
HGNCi | HGNC:30064, PBRM1 |
OpenTargetsi | ENSG00000163939 |
VEuPathDBi | HostDB:ENSG00000163939.18 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000003017 |
Miscellaneous databases
ChiTaRSi | PBRM1, human |
Gene expression databases
Bgeei | ENSG00000163939, Expressed in forebrain and 247 other tissues |
ExpressionAtlasi | H0Y5B5, baseline and differential |
Family and domain databases
CDDi | cd05515, Bromo_polybromo_V, 1 hit |
Gene3Di | 1.20.920.10, 6 hits 2.30.30.490, 1 hit |
InterProi | View protein in InterPro IPR001025, BAH_dom IPR043151, BAH_sf IPR001487, Bromodomain IPR036427, Bromodomain-like_sf IPR018359, Bromodomain_CS IPR037968, PBRM1_BD5 IPR037382, Rsc/polybromo |
PANTHERi | PTHR16062, PTHR16062, 2 hits |
Pfami | View protein in Pfam PF01426, BAH, 1 hit PF00439, Bromodomain, 6 hits |
PRINTSi | PR00503, BROMODOMAIN |
SMARTi | View protein in SMART SM00439, BAH, 1 hit SM00297, BROMO, 6 hits |
SUPFAMi | SSF47370, SSF47370, 6 hits |
PROSITEi | View protein in PROSITE PS51038, BAH, 1 hit PS00633, BROMODOMAIN_1, 5 hits PS50014, BROMODOMAIN_2, 6 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H0Y5B5_HUMAN | |
Accessioni | H0Y5B5Primary (citable) accession number: H0Y5B5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 22, 2012 |
Last sequence update: | February 22, 2012 | |
Last modified: | February 10, 2021 | |
This is version 64 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |