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Entry version 60 (12 Aug 2020)
Sequence version 1 (22 Feb 2012)
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Protein
Submitted name:

SH3 and PX domain-containing protein 2A

Gene

SH3PXD2A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
SH3 and PX domain-containing protein 2AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SH3PXD2AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000107957.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23664, SH3PXD2A

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000107957

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
H0Y507

MaxQB - The MaxQuant DataBase

More...
MaxQBi
H0Y507

PeptideAtlas

More...
PeptideAtlasi
H0Y507

PRoteomics IDEntifications database

More...
PRIDEi
H0Y507

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
34871

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000107957, Expressed in uterine cervix and 230 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
H0Y507, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
H0Y507, 2 interactors

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 83PXInterPro annotationAdd BLAST83
Domaini121 – 180SH3InterPro annotationAdd BLAST60
Domaini193 – 252SH3InterPro annotationAdd BLAST60
Domaini375 – 434SH3InterPro annotationAdd BLAST60
Domaini767 – 826SH3InterPro annotationAdd BLAST60
Domaini999 – 1060SH3InterPro annotationAdd BLAST62

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni280 – 299DisorderedSequence analysisAdd BLAST20
Regioni342 – 372DisorderedSequence analysisAdd BLAST31
Regioni432 – 767DisorderedSequence analysisAdd BLAST336
Regioni824 – 850DisorderedSequence analysisAdd BLAST27
Regioni869 – 892DisorderedSequence analysisAdd BLAST24
Regioni956 – 986DisorderedSequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi285 – 299PolyampholyteSequence analysisAdd BLAST15
Compositional biasi562 – 599PolarSequence analysisAdd BLAST38
Compositional biasi607 – 646PolarSequence analysisAdd BLAST40
Compositional biasi689 – 710PolarSequence analysisAdd BLAST22
Compositional biasi726 – 754PolarSequence analysisAdd BLAST29

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157732

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12074, SH3_Tks5_1, 1 hit
cd12077, SH3_Tks5_2, 1 hit
cd12079, SH3_Tks5_3, 1 hit
cd12019, SH3_Tks5_4, 1 hit
cd12020, SH3_Tks5_5, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1520.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001683, Phox
IPR036871, PX_dom_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR034917, SH3PXD2A
IPR035450, SH3PXD2A_SH3_1
IPR035452, SH3PXD2A_SH3_2
IPR035449, SH3PXD2A_SH3_3
IPR035453, SH3PXD2A_SH3_4
IPR035454, SH3PXD2A_SH3_5

The PANTHER Classification System

More...
PANTHERi
PTHR15706:SF22, PTHR15706:SF22, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00787, PX, 1 hit
PF00018, SH3_1, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00326, SH3, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044, SSF50044, 5 hits
SSF64268, SSF64268, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50195, PX, 1 hit
PS50002, SH3, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

H0Y507-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XFFDLQMQLL DKFPIEGGQK DPKQRIIPFL PGKILFRRSH IRDVAVKRLK
60 70 80 90 100
PIDEYCRALV RLPPHISQCD EVFRFFEARP EDVNPPKEDY GSSKRKSVWL
110 120 130 140 150
SSWAESPKKD VTGADATAEP MILEQYVVVS NYKKQENSEL SLQAGEVVDV
160 170 180 190 200
IEKNESGWWF VSTSEEQGWV PATYLEAQNG TRDDSDINTS KTGEEEKYVT
210 220 230 240 250
VQPYTSQSKD EIGFEKGVTV EVIRKNLEGW WYIRYLGKEG WAPASYLKKA
260 270 280 290 300
KDDLPTRKKN LAGPVEIIGN IMEISNLLNK KASGDKETPP AEGEGHEAPI
310 320 330 340 350
AKKEISLPIL CNASNGSAVG VPDRTVSRLA QGSPAVARIA PQRAQISSPN
360 370 380 390 400
LRTRPPPRRE SSLGFQLPKP PEPPSVEVEY YTIAEFQSCI SDGISFRGGQ
410 420 430 440 450
KAEVIDKNSG GWWYVQIGEK EGWAPASYID KRKKPNLSRR TSTLTRPKVP
460 470 480 490 500
PPAPPSKPKE AEEGPTGASE SQDSPRKLKY EEPEYDIPAF GFDSEPELSE
510 520 530 540 550
EPVEDRASGE RRPAQPHRPS PASSLQRARF KVGESSEDVA LEEETIYENE
560 570 580 590 600
GFRPYAEDTL SARGSSGDSD SPGSSSLSLT RKNSPKSGSP KSSSLLKLKA
610 620 630 640 650
EKNAQAEMGK NHSSASFSSS ITINTTCCSS SSSSSSSLSK TSGDLKPRSA
660 670 680 690 700
SDAGIRGTPK VRAKKDADAN AGLTSCPRAK PSVRPKPFLN RAESQSQEKM
710 720 730 740 750
DISTLRRQLR PTGQLRGGLK GSKSEDSELP PQTASEAPSE GSRRSSSDLI
760 770 780 790 800
TLPATTPPCP TKKEWEGPAT SYMTCSAYQK VQDSEISFPA GVEVQVLEKQ
810 820 830 840 850
ESGWWYVRFG ELEGWAPSHY LVLDENEQPD PSGKELDTVP AKGRQNEGKS
860 870 880 890 900
DSLEKIERRV QALNTVNQSK KATPPIPSKP PGGFGKTSGT PAVKMRNGVR
910 920 930 940 950
QVAVRPQSVF VSPPPKDNNL SCALRRNESL TATDGLRGVR RNSSFSTARS
960 970 980 990 1000
AAAEAKGRLA ERAASQGSDS PLLPAQRNSI PVSPVRPKPI EKSQFIHNNL
1010 1020 1030 1040 1050
KDVYVSIADY EGDEETAGFQ EGVSMEVLER NPNGWWYCQI LDGVKPFKGW
1060
VPSNYLEKKN
Length:1,060
Mass (Da):116,479
Last modified:February 22, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iECE77EC9C46B49E1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5TCZ1SPD2A_HUMAN
SH3 and PX domain-containing protei...
SH3PXD2A FISH, KIAA0418, SH3MD1, TKS5
1,133Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL121929 Genomic DNA No translation available.
AL133355 Genomic DNA No translation available.
KF510327 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000420222; ENSP00000395781; ENSG00000107957

UCSC genome browser

More...
UCSCi
uc057vtl.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121929 Genomic DNA No translation available.
AL133355 Genomic DNA No translation available.
KF510327 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Protein-protein interaction databases

IntActiH0Y507, 2 interactors

Proteomic databases

EPDiH0Y507
MaxQBiH0Y507
PeptideAtlasiH0Y507
PRIDEiH0Y507
ProteomicsDBi34871

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
46067, 153 antibodies

Genome annotation databases

EnsembliENST00000420222; ENSP00000395781; ENSG00000107957
UCSCiuc057vtl.1, human

Organism-specific databases

EuPathDBiHostDB:ENSG00000107957.16
HGNCiHGNC:23664, SH3PXD2A
OpenTargetsiENSG00000107957

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000157732

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SH3PXD2A, human

Gene expression databases

BgeeiENSG00000107957, Expressed in uterine cervix and 230 other tissues
ExpressionAtlasiH0Y507, baseline and differential

Family and domain databases

CDDicd12074, SH3_Tks5_1, 1 hit
cd12077, SH3_Tks5_2, 1 hit
cd12079, SH3_Tks5_3, 1 hit
cd12019, SH3_Tks5_4, 1 hit
cd12020, SH3_Tks5_5, 1 hit
Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR001683, Phox
IPR036871, PX_dom_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR034917, SH3PXD2A
IPR035450, SH3PXD2A_SH3_1
IPR035452, SH3PXD2A_SH3_2
IPR035449, SH3PXD2A_SH3_3
IPR035453, SH3PXD2A_SH3_4
IPR035454, SH3PXD2A_SH3_5
PANTHERiPTHR15706:SF22, PTHR15706:SF22, 1 hit
PfamiView protein in Pfam
PF00787, PX, 1 hit
PF00018, SH3_1, 4 hits
SMARTiView protein in SMART
SM00326, SH3, 5 hits
SUPFAMiSSF50044, SSF50044, 5 hits
SSF64268, SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195, PX, 1 hit
PS50002, SH3, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH0Y507_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H0Y507
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: August 12, 2020
This is version 60 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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