Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

SH3 and PX domain-containing protein 2A

Gene

SH3PXD2A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
SH3 and PX domain-containing protein 2AImported
Gene namesi
Name:SH3PXD2AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000107957.16
HGNCiHGNC:23664 SH3PXD2A

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000107957

PTM / Processingi

Proteomic databases

EPDiH0Y507
MaxQBiH0Y507
PeptideAtlasiH0Y507
PRIDEiH0Y507

Expressioni

Gene expression databases

BgeeiENSG00000107957 Expressed in 219 organ(s), highest expression level in uterine cervix
ExpressionAtlasiH0Y507 baseline and differential

Interactioni

Protein-protein interaction databases

IntActiH0Y507, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliH0Y507
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 83PXInterPro annotationAdd BLAST83
Domaini121 – 180SH3InterPro annotationAdd BLAST60
Domaini193 – 252SH3InterPro annotationAdd BLAST60
Domaini375 – 434SH3InterPro annotationAdd BLAST60
Domaini767 – 826SH3InterPro annotationAdd BLAST60
Domaini999 – 1060SH3InterPro annotationAdd BLAST62

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili853 – 873Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4773 Eukaryota
ENOG410YBFF LUCA
GeneTreeiENSGT00530000063010

Family and domain databases

CDDicd12074 SH3_Tks5_1, 1 hit
cd12077 SH3_Tks5_2, 1 hit
cd12079 SH3_Tks5_3, 1 hit
cd12019 SH3_Tks5_4, 1 hit
cd12020 SH3_Tks5_5, 1 hit
Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR001683 Phox
IPR036871 PX_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR034917 SH3PXD2A
IPR035450 SH3PXD2A_SH3_1
IPR035452 SH3PXD2A_SH3_2
IPR035449 SH3PXD2A_SH3_3
IPR035453 SH3PXD2A_SH3_4
IPR035454 SH3PXD2A_SH3_5
PANTHERiPTHR15706:SF7 PTHR15706:SF7, 3 hits
PfamiView protein in Pfam
PF00787 PX, 1 hit
PF00018 SH3_1, 4 hits
SMARTiView protein in SMART
SM00326 SH3, 5 hits
SUPFAMiSSF50044 SSF50044, 5 hits
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit
PS50002 SH3, 5 hits

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

H0Y507-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XFFDLQMQLL DKFPIEGGQK DPKQRIIPFL PGKILFRRSH IRDVAVKRLK
60 70 80 90 100
PIDEYCRALV RLPPHISQCD EVFRFFEARP EDVNPPKEDY GSSKRKSVWL
110 120 130 140 150
SSWAESPKKD VTGADATAEP MILEQYVVVS NYKKQENSEL SLQAGEVVDV
160 170 180 190 200
IEKNESGWWF VSTSEEQGWV PATYLEAQNG TRDDSDINTS KTGEEEKYVT
210 220 230 240 250
VQPYTSQSKD EIGFEKGVTV EVIRKNLEGW WYIRYLGKEG WAPASYLKKA
260 270 280 290 300
KDDLPTRKKN LAGPVEIIGN IMEISNLLNK KASGDKETPP AEGEGHEAPI
310 320 330 340 350
AKKEISLPIL CNASNGSAVG VPDRTVSRLA QGSPAVARIA PQRAQISSPN
360 370 380 390 400
LRTRPPPRRE SSLGFQLPKP PEPPSVEVEY YTIAEFQSCI SDGISFRGGQ
410 420 430 440 450
KAEVIDKNSG GWWYVQIGEK EGWAPASYID KRKKPNLSRR TSTLTRPKVP
460 470 480 490 500
PPAPPSKPKE AEEGPTGASE SQDSPRKLKY EEPEYDIPAF GFDSEPELSE
510 520 530 540 550
EPVEDRASGE RRPAQPHRPS PASSLQRARF KVGESSEDVA LEEETIYENE
560 570 580 590 600
GFRPYAEDTL SARGSSGDSD SPGSSSLSLT RKNSPKSGSP KSSSLLKLKA
610 620 630 640 650
EKNAQAEMGK NHSSASFSSS ITINTTCCSS SSSSSSSLSK TSGDLKPRSA
660 670 680 690 700
SDAGIRGTPK VRAKKDADAN AGLTSCPRAK PSVRPKPFLN RAESQSQEKM
710 720 730 740 750
DISTLRRQLR PTGQLRGGLK GSKSEDSELP PQTASEAPSE GSRRSSSDLI
760 770 780 790 800
TLPATTPPCP TKKEWEGPAT SYMTCSAYQK VQDSEISFPA GVEVQVLEKQ
810 820 830 840 850
ESGWWYVRFG ELEGWAPSHY LVLDENEQPD PSGKELDTVP AKGRQNEGKS
860 870 880 890 900
DSLEKIERRV QALNTVNQSK KATPPIPSKP PGGFGKTSGT PAVKMRNGVR
910 920 930 940 950
QVAVRPQSVF VSPPPKDNNL SCALRRNESL TATDGLRGVR RNSSFSTARS
960 970 980 990 1000
AAAEAKGRLA ERAASQGSDS PLLPAQRNSI PVSPVRPKPI EKSQFIHNNL
1010 1020 1030 1040 1050
KDVYVSIADY EGDEETAGFQ EGVSMEVLER NPNGWWYCQI LDGVKPFKGW
1060
VPSNYLEKKN
Length:1,060
Mass (Da):116,479
Last modified:February 22, 2012 - v1
Checksum:iECE77EC9C46B49E1
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5TCZ1SPD2A_HUMAN
SH3 and PX domain-containing protei...
SH3PXD2A FISH, KIAA0418, SH3MD1, TKS5
1,133Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121929 Genomic DNA No translation available.
AL133355 Genomic DNA No translation available.
KF510327 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000420222; ENSP00000395781; ENSG00000107957
UCSCiuc057vtl.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121929 Genomic DNA No translation available.
AL133355 Genomic DNA No translation available.
KF510327 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH0Y507
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiH0Y507, 2 interactors

Proteomic databases

EPDiH0Y507
MaxQBiH0Y507
PeptideAtlasiH0Y507
PRIDEiH0Y507

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000420222; ENSP00000395781; ENSG00000107957
UCSCiuc057vtl.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000107957.16
HGNCiHGNC:23664 SH3PXD2A
OpenTargetsiENSG00000107957
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4773 Eukaryota
ENOG410YBFF LUCA
GeneTreeiENSGT00530000063010

Miscellaneous databases

ChiTaRSiSH3PXD2A human

Gene expression databases

BgeeiENSG00000107957 Expressed in 219 organ(s), highest expression level in uterine cervix
ExpressionAtlasiH0Y507 baseline and differential

Family and domain databases

CDDicd12074 SH3_Tks5_1, 1 hit
cd12077 SH3_Tks5_2, 1 hit
cd12079 SH3_Tks5_3, 1 hit
cd12019 SH3_Tks5_4, 1 hit
cd12020 SH3_Tks5_5, 1 hit
Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR001683 Phox
IPR036871 PX_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR034917 SH3PXD2A
IPR035450 SH3PXD2A_SH3_1
IPR035452 SH3PXD2A_SH3_2
IPR035449 SH3PXD2A_SH3_3
IPR035453 SH3PXD2A_SH3_4
IPR035454 SH3PXD2A_SH3_5
PANTHERiPTHR15706:SF7 PTHR15706:SF7, 3 hits
PfamiView protein in Pfam
PF00787 PX, 1 hit
PF00018 SH3_1, 4 hits
SMARTiView protein in SMART
SM00326 SH3, 5 hits
SUPFAMiSSF50044 SSF50044, 5 hits
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit
PS50002 SH3, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiH0Y507_HUMAN
AccessioniPrimary (citable) accession number: H0Y507
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: September 12, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again