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UniProtKB - H0Y4U7 (H0Y4U7_HUMAN)

Entry version 60 (02 Dec 2020)
Sequence version 2 (09 Jan 2013)
Previous versions | rss
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Protein
Submitted name:

ATP-binding cassette sub-family A member 9

Gene

ABCA9

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi517 – 524ATPPROSITE-ProRule annotation8
Nucleotide bindingi1288 – 1295ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ATP-binding cassette sub-family A member 9Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ABCA9Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000154258.16

Human Gene Nomenclature Database

More...HGNCi		HGNC:39, ABCA9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei31 – 48HelicalSequence analysisAdd BLAST18
Transmembranei215 – 241HelicalSequence analysisAdd BLAST27
Transmembranei265 – 287HelicalSequence analysisAdd BLAST23
Transmembranei294 – 323HelicalSequence analysisAdd BLAST30
Transmembranei329 – 350HelicalSequence analysisAdd BLAST22
Transmembranei357 – 378HelicalSequence analysisAdd BLAST22
Transmembranei398 – 420HelicalSequence analysisAdd BLAST23
Transmembranei1026 – 1045HelicalSequence analysisAdd BLAST20
Transmembranei1065 – 1085HelicalSequence analysisAdd BLAST21
Transmembranei1097 – 1116HelicalSequence analysisAdd BLAST20
Transmembranei1123 – 1145HelicalSequence analysisAdd BLAST23
Transmembranei1165 – 1185HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000154258

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		34830

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000154258, Expressed in sural nerve and 189 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		H0Y4U7, baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini481 – 716ABC transporterInterPro annotationAdd BLAST236
Domaini1250 – 1483ABC transporterInterPro annotationAdd BLAST234

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162444

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000604_19_1_1

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003593, AAA+_ATPase
IPR003439, ABC_transporter-like
IPR026082, ABCA
IPR027417, P-loop_NTPase

The PANTHER Classification System

More...PANTHERi		PTHR19229, PTHR19229, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00005, ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00382, AAA, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50893, ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

H0Y4U7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKRRMSVGQ QTWALLCKNC LKKWRMKRQT LLEWLFSFLL VLFLYLFFSN 
        60         70         80         90        100
LHQVHDTPQM SSMDLGRVDS FNDTNYVIAF APESKTTQEI MNKVASAPFL 
       110        120        130        140        150
KGRTIMGWPD EKSMDELDLN YSIDAVRVIF TDTFSYHLKF SWGHRIPMMK 
       160        170        180        190        200
EHRDHSAHCQ AVNEKMKCEG SEFWEKGFVA FQAAINAAII EIATNHSVME 
       210        220        230        240        250
QLMSVTGVHM KILPFVAQGG VATDFFIFFC IISFSTFIYY VSVNVTQERQ 
       260        270        280        290        300
YITSLMTMMG LRESAFWLSW GLMYAGFILI MATLMALIVK SAQIVVLTGF 
       310        320        330        340        350
VMVFTLFLLY GLSLITLAFL MSVLIKKPFL TGLVVFLLIV FWGILGFPAL 
       360        370        380        390        400
YTRLPAFLEW TLCLLSPFAF TVGMAQLIHL DYDVNSNAHL DSSQNPYLII 
       410        420        430        440        450
ATLFMLVFDT LLYLVLTLYF DKILPAEYGH RCSPLFFLKS CFWFQHGRAN 
       460        470        480        490        500
HVVLENETDS DPTPNDCFEP VSPEFCGKEA IRIKNLKKEY AGKCERVEAL 
       510        520        530        540        550
KGVVFDIYEG QITALLGHSG AGKTTLLNIL SGLSVPTSGS VTVYNHTLSR 
       560        570        580        590        600
MADIENISKF TGFCPQSNVQ FGFLTVKENL RLFAKIKGIL PHEVEKEVQR 
       610        620        630        640        650
VVQELEMENI QDILAQNLSG GQNRKLTFGI AILGDPQVLL LDEPTAGLDP 
       660        670        680        690        700
LSRHRIWNLL KEGKSDRVIL FSTQFIDEAD ILADRKVFIS NGKLKCAGSS 
       710        720        730        740        750
LFLKKKWGIG YHLSLHLNER CDPESITSLV KQHISDAKLT AQSEEKLVYI 
       760        770        780        790        800
LPLERTNKFP ELYRDLDRCS NQGIEDYGVS ITTLNEVFLK LEGKSTIDES 
       810        820        830        840        850
DIGIWGQLQT DGAKDIGSLV ELEQVLSSFH ETRKTISGVA LWRQQVCAIA 
       860        870        880        890        900
KVRFLKLKKE RKSLWTILLL FGISFIPQLL EHLFYESYQK SYPWELSPNT 
       910        920        930        940        950
YFLSPGQQPQ DPLTHLLVIN KTGSTIDNFL HSLRRQNIAI EVDAFGTRNG 
       960        970        980        990       1000
TDDPSYNGAI IVSGDEKDHR FSIACNTKRL NCFPVLLDVI SNGLLGIFNS 
      1010       1020       1030       1040       1050
SEHIQTDRST FFEEHMDYEY GYRSNTFFWI PMAASFTPYI AMSSIGDYKK 
      1060       1070       1080       1090       1100
KAHSQLRISG LYPSAYWFGQ ALVDVSLYFL ILLLMQIMDY IFSPEEIIFI 
      1110       1120       1130       1140       1150
IQNLLIQVVI FSIVATDLNE YGFLGLFFGT MLIPPFTLIG SLFIFSEISP 
      1160       1170       1180       1190       1200
DSMDYLGASE SEIVYLALLI PYLHFLIFLF ILRCLEMNCR KKLMRKDPVF 
      1210       1220       1230       1240       1250
RISPRSNAIF PNPEEPEGEE EDIQMERMRT VNAMAVRDFD ETPVIIASCL 
      1260       1270       1280       1290       1300
RKEYAGKKKN CFSKRKKKIA TRNVSFCVKK GEVIGLLGHN GAGKSTTIKM 
      1310       1320       1330       1340       1350
ITGDTKPTAG QVILKGSGGG EPLGFLGYCP QENALWPNLT VRQHLEVYAA 
      1360       1370       1380       1390       1400
VKGLRKGDAM IAITRLVDAL KLQDQLKAPV KTLSEGIKRK LCFVLSILGN 
      1410       1420       1430       1440       1450
PSVVLLDEPS TGMDPEGQQQ MWQVIRATFR NTERGALLTT HYMAEAEAVC 
      1460       1470       1480       1490       1500
DRVAIMVSGR LRCIGSIQHL KSKFGKDYLL EMKLKNLAQM EPLHAEILRL 
      1510       1520       1530       1540       1550
FPQAAQQERF SSLMVYKLPV EDVRPLSQAF FKLEIVKQSF DLEEYSLSQS 
      1560       1570       1580 
TLEQVFLELS KEQELGDLEE DFDPSVKWKL LLQEEP
Length:1,586
Mass (Da):179,970
Last modified:January 9, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i22C72E2D3603073D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8IUA7ABCA9_HUMAN
ATP-binding cassette sub-family A m...
ABCA9
1,624Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJJ0K7EJJ0_HUMAN
ATP-binding cassette sub-family A m...
ABCA9
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC005922 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000453985; ENSP00000394264; ENSG00000154258

UCSC genome browser

More...UCSCi		uc010dez.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005922 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Proteomic databases

ProteomicsDBi34830

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		31822, 170 antibodies

Genome annotation databases

EnsembliENST00000453985; ENSP00000394264; ENSG00000154258
UCSCiuc010dez.4, human

Organism-specific databases

EuPathDBiHostDB:ENSG00000154258.16
HGNCiHGNC:39, ABCA9
OpenTargetsiENSG00000154258

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

GeneTreeiENSGT00940000162444
HOGENOMiCLU_000604_19_1_1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ABCA9, human

Gene expression databases

BgeeiENSG00000154258, Expressed in sural nerve and 189 other tissues
ExpressionAtlasiH0Y4U7, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR003439, ABC_transporter-like
IPR026082, ABCA
IPR027417, P-loop_NTPase
PANTHERiPTHR19229, PTHR19229, 2 hits
PfamiView protein in Pfam
PF00005, ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382, AAA, 2 hits
SUPFAMiSSF52540, SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS50893, ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH0Y4U7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H0Y4U7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: January 9, 2013
Last modified: December 2, 2020
This is version 60 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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