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Protein
Submitted name:

Serine/threonine-protein kinase SIK3

Gene

SIK3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Enzyme and pathway databases

SignaLinkiH0Y4E8

Names & Taxonomyi

Protein namesi
Submitted name:
Serine/threonine-protein kinase SIK3Imported
Gene namesi
Name:SIK3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000160584.15
HGNCiHGNC:29165 SIK3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000160584

PTM / Processingi

Proteomic databases

EPDiH0Y4E8
MaxQBiH0Y4E8
PeptideAtlasiH0Y4E8
PRIDEiH0Y4E8

Expressioni

Gene expression databases

BgeeiENSG00000160584 Expressed in 231 organ(s), highest expression level in corpus callosum
ExpressionAtlasiH0Y4E8 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH0Y4E8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini60 – 311Protein kinaseInterPro annotationAdd BLAST252
Domaini338 – 378UBAInterPro annotationAdd BLAST41

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili683 – 710Sequence analysisAdd BLAST28
Coiled coili1038 – 1060Sequence analysisAdd BLAST23

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0586 Eukaryota
ENOG410XNQ0 LUCA
GeneTreeiENSGT00900000140806
OMAiMSLMAGK
OrthoDBiEOG091G00NG
PhylomeDBiH0Y4E8

Family and domain databases

CDDicd14071 STKc_SIK, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR034672 SIK
IPR015940 UBA
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50030 UBA, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

H0Y4E8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XGAGGAAGAG TGGAGPAGRL LPPPAPGSPA APAAVSPAAG QPRPPAPASR
60 70 80 90 100
GPMPARIGYY EIDRTIGKGN FAVVKRATHL VTKAKVAIKI IDKTQLDEEN
110 120 130 140 150
LKKIFREVQI MKMLCHPHII RLYQVMETER MIYLVTEYAS GGEIFDHLVA
160 170 180 190 200
HGRMAEKEAR RKFKQIVTAV YFCHCRNIVH RDLKAENLLL DANLNIKIAD
210 220 230 240 250
FGFSNLFTPG QLLKTWCGSP PYAAPELFEG KEYDGPKVDI WSLGVVLYVL
260 270 280 290 300
VCGALPFDGS TLQNLRARVL SGKFRIPFFM STECEHLIRH MLVLDPNKRL
310 320 330 340 350
SMEQICKHKW MKLGDADPNF DRLIAECQQL KEERQVDPLN EDVLLAMEDM
360 370 380 390 400
GLDKEQTLQS LRSDAYDHYS AIYSLLCDRH KRHKTLRLGA LPSMPRALAF
410 420 430 440 450
QAPVNIQAEQ AGTAMNISVP QVQLINPENQ IVEPDGTLNL DSDEGEEPSP
460 470 480 490 500
EALVRYLSMR RHTVGVADPR TEVMEDLQKL LPGFPGVNPQ APFLQVAPNV
510 520 530 540 550
NFMHNLLPMQ NLQPTGQLEY KEQSLLQPPT LQLLNGMGPL GRRASDGGAN
560 570 580 590 600
IQLHAQQLLK RPRGPSPLVT MTPAVPAVTP VDEESSDGEP DQEAVQRYLA
610 620 630 640 650
NRSKRHTLAM TNPTAEIPPD LQRQLGQQPF RSRVWPPHLV PDQHRSTYKD
660 670 680 690 700
SNTLHLPTER FSPVRRFSDG AASIQAFKAH LEKMGNNSSI KQLQQECEQL
710 720 730 740 750
QKMYGGQIDE RTLEKTQQQH MLYQQEQHHQ ILQQQIQDSI CPPQPSPPLQ
760 770 780 790 800
AACENQPALL THQLQRLRIQ PSSPPPNHPN NHLFRQPSNS PPPMSSAMIQ
810 820 830 840 850
PHGAASSSQF QGLPSRSAIF QQQPENCSSP PNVALTCLGM QQPAQSQQVT
860 870 880 890 900
IQVQEPVDML SNMPGTAAGS SGRGISISPS AGQMQMQHRT NLMATLSYGH
910 920 930 940 950
RPLSKQLSAD SAEAHSLNVN RFSPANYDQA HLHPHLFSDQ SRGSPSSYSP
960 970 980 990 1000
STGVGFSPTQ ALKVPPLDQF PTFPPSAHQQ PPHYTTSALQ QALLSPTPPD
1010 1020 1030 1040 1050
YTRHQQVPHI LQGLLSPRHS LTGHSDIRLP PTEFAQLIKR QQQQRQQQQQ
1060 1070 1080 1090 1100
QQQQQEYQEL FRHMNQGDAG SLAPSLGGQS MTERQALSYQ NADSYHHHTS
1110 1120 1130 1140 1150
PQHLLQIRAQ ECVSQASSPT PPHGYAHQPA LMHSESMEED CSCEGAKDGF
1160 1170 1180 1190 1200
QDSKSSSTLT KGCHDSPLLL STGGPGDPES LLGTVSHAQE LGIHPYGHQP
1210 1220 1230 1240 1250
TAAFSKNKVP SREPVIGNCM DRSSPGQAVE LPDHNGLGYP ARPSVHEHHR
1260 1270 1280 1290 1300
PRALQRHHTI QNSDDAYVQL DNLPGMSLVA GKALSSARMS DAVLSQSSLM
1310 1320 1330 1340 1350
GSQQFQDGEN EECGASLGGH EHPDLSDGSQ HLNSSCYPST CITDILLSYK
1360
HPEVSFSMEQ AGV
Length:1,363
Mass (Da):150,096
Last modified:February 22, 2012 - v1
Checksum:i9236E61AE47FB50D
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9Y2K2SIK3_HUMAN
Serine/threonine-protein kinase SIK...
SIK3 KIAA0999, QSK, L19
1,321Annotation score:
H7C3X8H7C3X8_HUMAN
Serine/threonine-protein kinase SIK...
SIK3
506Annotation score:
H7C038H7C038_HUMAN
Serine/threonine-protein kinase SIK...
SIK3
151Annotation score:
H7C042H7C042_HUMAN
Serine/threonine-protein kinase SIK...
SIK3
71Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000936 Genomic DNA No translation available.
AP003070 Genomic DNA No translation available.
AP006216 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000445177; ENSP00000391295; ENSG00000160584
UCSCiuc058hre.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000936 Genomic DNA No translation available.
AP003070 Genomic DNA No translation available.
AP006216 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH0Y4E8
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiH0Y4E8
MaxQBiH0Y4E8
PeptideAtlasiH0Y4E8
PRIDEiH0Y4E8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000445177; ENSP00000391295; ENSG00000160584
UCSCiuc058hre.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000160584.15
HGNCiHGNC:29165 SIK3
OpenTargetsiENSG00000160584
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0586 Eukaryota
ENOG410XNQ0 LUCA
GeneTreeiENSGT00900000140806
OMAiMSLMAGK
OrthoDBiEOG091G00NG
PhylomeDBiH0Y4E8

Enzyme and pathway databases

SignaLinkiH0Y4E8

Miscellaneous databases

ChiTaRSiSIK3 human

Gene expression databases

BgeeiENSG00000160584 Expressed in 231 organ(s), highest expression level in corpus callosum
ExpressionAtlasiH0Y4E8 baseline and differential

Family and domain databases

CDDicd14071 STKc_SIK, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR034672 SIK
IPR015940 UBA
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50030 UBA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH0Y4E8_HUMAN
AccessioniPrimary (citable) accession number: H0Y4E8
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: November 7, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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