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Entry version 47 (08 May 2019)
Sequence version 1 (22 Feb 2012)
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Protein
Submitted name:

Astrotactin-2

Gene

ASTN2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Astrotactin-2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ASTN2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17021 ASTN2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000148219

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
H0Y3A8

PeptideAtlas

More...
PeptideAtlasi
H0Y3A8

PRoteomics IDEntifications database

More...
PRIDEi
H0Y3A8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000148219 Expressed in 188 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
H0Y3A8 baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini574 – 758MACPFInterPro annotationAdd BLAST185

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003140

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040685 Annexin-like
IPR040510 ASTN_2_hairpin
IPR026995 Astrotactin
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR020864 MACPF

The PANTHER Classification System

More...
PANTHERi
PTHR16592 PTHR16592, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18411 Annexin_like, 1 hit
PF18577 ASTN_2_hairpin, 1 hit
PF01823 MACPF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00457 MACPF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

H0Y3A8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
QTHNSVIGVP IRETPILDDY DCEEDEEPPR RANHVSREDE FGSQVTHTLD
60 70 80 90 100
SLGHPGEEKV DFEKKAAAEA TQETVESLMQ KFKESFRANT PIEIGQLQPP
110 120 130 140 150
LRSTSAGKRK RRSKSRGGIS FGRAKGTSGS EADDETQLTF YTEQYRSRRR
160 170 180 190 200
SKGLLKSPVN KTALTLIAVS SCILAMVCGS QMSCPLTVKV TLHVPEHFIA
210 220 230 240 250
DGSSFVVSEG SYLDISDWLN PAKLSLYYQI NATSPWVRDL CGQRTTDACE
260 270 280 290 300
QLCDPETGEC SCHEGYAPDP VHRHLCVRSD WGQSEGPWPY TTLERGYDLV
310 320 330 340 350
TGEQAPEKIL SLGQGLWLPV SKSFVVPPVE LSINPLASCK TDVLVTEDPA
360 370 380 390 400
DVREEAMLST YFETINDLLS SFGPVRDCSR NNGGCTRNFK CVSDRQVDSS
410 420 430 440 450
GCVCPEELKP MKDGSGCYDH SKGIDCSDGF NGGCEQLCLQ QTLPLPYDAT
460 470 480 490 500
SSTIFMFCGC VEEYKLAPDG KSCLMLSDVC EGPKCLKPDS KFNDTLFGEM
510 520 530 540 550
LHGYNNRTQH VNQGQVFQMT FRENNFIKDF PQLADGLLVI PLPVEEQCRG
560 570 580 590 600
VLSEPLPDLQ LLTGDIRYDE AMGYPMVQQW RVRSNLYRVK LSTITLAAGF
610 620 630 640 650
TNVLKILTKE SSREELLSFI QHYGSHYIAE ALYGSELTCI IHFPSKKVQQ
660 670 680 690 700
QLWLQYQKET TELGSKKELK SMPFITYLSG LLTAQMLSDD QLISGVEIRC
710 720 730 740 750
EEKGRCPSTC HLCRRPGKEQ LSPTPVLLEI NRVVPLYTLI QDNGTKEAFK
760 770 780 790 800
SALMSSYWCS GKGDVIDDWC RCDLSAFDAN GLPNCSPLLQ PVLRLSPTVE
810 820 830 840 850
PSSTVVSLEW VDVQPAIGTK VSDYILQHKK VDEYTDTDLY TGEFLSFADD
860 870 880 890 900
LLSGLGTSCV AAGRSHGEVP EVSIYSVIFK CLEPDGLYKF TLYAVDTRGR
910 920 930 940 950
HSELSTVTLR TACPLVDDNK AEEIADKIYN LYNGYTSGKE QQMAYNTLME
960 970 980 990 1000
VSASMLFRVQ HHYNSHYEKF GDFVWRSEDE LGPRKAHLIL RRLERVSSHC
1010 1020 1030 1040 1050
SSLLRSAYIQ SRVETVPYLF CRSEEVRPAG MVWYSILKDT KITCEEKMVS
1060
MARNTYGESK GR
Length:1,062
Mass (Da):118,833
Last modified:February 22, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2765632C0F503E22
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O75129ASTN2_HUMAN
Astrotactin-2
ASTN2 KIAA0634
1,339Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7ZKP5B7ZKP5_HUMAN
ASTN2 protein
ASTN2
402Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6R5P2X6R5P2_HUMAN
Astrotactin-2
ASTN2
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3I6H7C3I6_HUMAN
Astrotactin-2
ASTN2
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL133282 Genomic DNA No translation available.
AL133284 Genomic DNA No translation available.
AL137024 Genomic DNA No translation available.
AL157829 Genomic DNA No translation available.
AL354981 Genomic DNA No translation available.
AL355608 Genomic DNA No translation available.
AL392085 Genomic DNA No translation available.
AL669963 Genomic DNA No translation available.
KF458941 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000373986; ENSP00000363098; ENSG00000148219

UCSC genome browser

More...
UCSCi
uc064vhl.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL133282 Genomic DNA No translation available.
AL133284 Genomic DNA No translation available.
AL137024 Genomic DNA No translation available.
AL157829 Genomic DNA No translation available.
AL354981 Genomic DNA No translation available.
AL355608 Genomic DNA No translation available.
AL392085 Genomic DNA No translation available.
AL669963 Genomic DNA No translation available.
KF458941 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

jPOSTiH0Y3A8
PeptideAtlasiH0Y3A8
PRIDEiH0Y3A8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373986; ENSP00000363098; ENSG00000148219
UCSCiuc064vhl.1 human

Organism-specific databases

HGNCiHGNC:17021 ASTN2
OpenTargetsiENSG00000148219

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00390000003140

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ASTN2 human

Gene expression databases

BgeeiENSG00000148219 Expressed in 188 organ(s), highest expression level in testis
ExpressionAtlasiH0Y3A8 baseline and differential

Family and domain databases

CDDicd00063 FN3, 1 hit
InterProiView protein in InterPro
IPR040685 Annexin-like
IPR040510 ASTN_2_hairpin
IPR026995 Astrotactin
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR020864 MACPF
PANTHERiPTHR16592 PTHR16592, 1 hit
PfamiView protein in Pfam
PF18411 Annexin_like, 1 hit
PF18577 ASTN_2_hairpin, 1 hit
PF01823 MACPF, 1 hit
SMARTiView protein in SMART
SM00457 MACPF, 1 hit
SUPFAMiSSF49265 SSF49265, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH0Y3A8_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H0Y3A8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: May 8, 2019
This is version 47 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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