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Entry version 72 (19 Jan 2022)
Sequence version 1 (22 Feb 2012)
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Protein
Submitted name:

Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5

Gene

MACF1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi4100 – 4111PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi4136 – 4147PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingARBA annotation
LigandCalciumPROSITE-ProRule annotation, Metal-bindingPROSITE-ProRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MACF1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13664, MACF1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000127603

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, CytoskeletonPROSITE-ProRule annotation

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000127603

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
H0Y390

MaxQB - The MaxQuant DataBase

More...
MaxQBi
H0Y390

PeptideAtlas

More...
PeptideAtlasi
H0Y390

PRoteomics IDEntifications database

More...
PRIDEi
H0Y390

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
34461

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000127603, Expressed in corpus callosum and 250 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
H0Y390, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 59SH3InterPro annotationAdd BLAST58
Domaini4087 – 4122EF-handInterPro annotationAdd BLAST36
Domaini4123 – 4158EF-handInterPro annotationAdd BLAST36
Domaini4163 – 4235GARInterPro annotationAdd BLAST73

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2628 – 2649DisorderedSequence analysisAdd BLAST22
Regioni3997 – 4030DisorderedSequence analysisAdd BLAST34
Regioni4251 – 4434DisorderedSequence analysisAdd BLAST184

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili180 – 200Sequence analysisAdd BLAST21
Coiled coili537 – 567Sequence analysisAdd BLAST31
Coiled coili631 – 651Sequence analysisAdd BLAST21
Coiled coili656 – 683Sequence analysisAdd BLAST28
Coiled coili763 – 797Sequence analysisAdd BLAST35
Coiled coili927 – 957Sequence analysisAdd BLAST31
Coiled coili1321 – 1348Sequence analysisAdd BLAST28
Coiled coili1368 – 1388Sequence analysisAdd BLAST21
Coiled coili1426 – 1446Sequence analysisAdd BLAST21
Coiled coili1510 – 1530Sequence analysisAdd BLAST21
Coiled coili1670 – 1690Sequence analysisAdd BLAST21
Coiled coili1729 – 1749Sequence analysisAdd BLAST21
Coiled coili1770 – 1804Sequence analysisAdd BLAST35
Coiled coili1921 – 1941Sequence analysisAdd BLAST21
Coiled coili2042 – 2083Sequence analysisAdd BLAST42
Coiled coili2246 – 2266Sequence analysisAdd BLAST21
Coiled coili2357 – 2377Sequence analysisAdd BLAST21
Coiled coili2542 – 2562Sequence analysisAdd BLAST21
Coiled coili2901 – 2921Sequence analysisAdd BLAST21
Coiled coili3137 – 3164Sequence analysisAdd BLAST28
Coiled coili3349 – 3369Sequence analysisAdd BLAST21
Coiled coili3916 – 3936Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2633 – 2648Polar residuesSequence analysisAdd BLAST16
Compositional biasi4270 – 4349Polar residuesSequence analysisAdd BLAST80
Compositional biasi4381 – 4434Polar residuesSequence analysisAdd BLAST54

Keywords - Domaini

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155824

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00051, EFh, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.920.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR003108, GAR_dom
IPR036534, GAR_dom_sf
IPR043197, Plakin
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR23169, PTHR23169, 6 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13499, EF-hand_7, 1 hit
PF02187, GAS2, 1 hit
PF17902, SH3_10, 1 hit
PF00435, Spectrin, 18 hits
PF18373, Spectrin_like, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00054, EFh, 2 hits
SM00243, GAS2, 1 hit
SM00150, SPEC, 30 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF143575, SSF143575, 1 hit
SSF47473, SSF47473, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS51460, GAR, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 21 potential isoforms that are computationally mapped.Show allAlign All

H0Y390-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XKNTISVKAV CDYRQIEITI CKNDECVLED NSQRTKWKVI SPTGNEAMVP
60 70 80 90 100
SVCFLIPPPN KDAIEMASRV EQSYQKVMAL WHQLHVNTKS LISWNYLRKD
110 120 130 140 150
LDLVQTWNLE KLRSSAPGEC HQIMKNLQAH YEDFLQDSRD SVLFSVADRL
160 170 180 190 200
RLEEEVEACK ARFQHLMKSM ENEDKEETVA KMYISELKNI RLRLEEYEQR
210 220 230 240 250
VVKRIQSLAS SRTDRDAWQD NALRIAEQEH TQEDLQQLRS DLDAVSMKCD
260 270 280 290 300
SFLHQSPSSS SVPTLRSELN LLVEKMDHVY GLSTVYLNKL KTVDVIVRSI
310 320 330 340 350
QDAELLVKGY EIKLSQEEVV LADLSALEAH WSTLRHWLSD VKDKNSVFSV
360 370 380 390 400
LDEEIAKAKV VAEQMSRLTP ERNLDLERYQ EKGSQLQERW HRVIAQLEIR
410 420 430 440 450
QSELESIQEV LGDYRACHGT LIKWIEETTA QQEMMKPGQA EDSRVLSEQL
460 470 480 490 500
SQQTALFAEI ERNQTKLDQC QKFSQQYSTI VKDYELQLMT YKAFVESQQK
510 520 530 540 550
SPGKRRRMLS SSDAITQEFM DLRTRYTALV TLTTQHVKYI SDALRRLEEE
560 570 580 590 600
EKVVEEEKQE HVEKVKELLG WVSTLARNTQ GKATSSETKE STDIEKAILE
610 620 630 640 650
QQVLSEELTT KKEQVSEAIK TSQIFLAKHG HKLSEKEKKQ ISEQLNALNK
660 670 680 690 700
AYHDLCDGSA NQLQQLQSQL AHQTEQKTLQ KQQNTCHQQL EDLCSWVGQA
710 720 730 740 750
ERALAGHQGR TTQQDLSALQ KNQSDLKDLQ DDIQNRATSF ATVVKDIEGF
760 770 780 790 800
MEENQTKLSP RELTALREKL HQAKEQYEAL QEETRVAQKE LEEAVTSALQ
810 820 830 840 850
QETEKSKAAK ELAENKKKID ALLDWVTSVG SSGGQLLTNL PGMEQLSGAS
860 870 880 890 900
LEKGALDTTD GYMGVNQAPE KLDKQCEMMK ARHQELLSQQ QNFILATQSA
910 920 930 940 950
QAFLDQHGHN LTPEEQQMLQ QKLGELKEQY STSLAQSEAE LKQVQTLQDE
960 970 980 990 1000
LQKFLQDHKE FESWLERSEK ELENMHKGGS SPETLPSLLK RQGSFSEDVI
1010 1020 1030 1040 1050
SHKGDLRFVT ISGQKVLDME NSFKEGKEPS EIGNLVKDKL KDATERYTAL
1060 1070 1080 1090 1100
HSKCTRLGSH LNMLLGQYHQ FQNSADSLQA WMQACEANVE KLLSDTVASD
1110 1120 1130 1140 1150
PGVLQEQLAT TKQLQEELAE HQVPVEKLQK VARDIMEIEG EPAPDHRHVQ
1160 1170 1180 1190 1200
ETTDSILSHF QSLSYSLAER SSLLQKAIAQ SQSVQESLES LLQSIGEVEQ
1210 1220 1230 1240 1250
NLEGKQVSSL SSGVIQEALA TNMKLKQDIA RQKSSLEATR EMVTRFMETA
1260 1270 1280 1290 1300
DSTTAAVLQG KLAEVSQRFE QLCLQQQEKE SSLKKLLPQA EMFEHLSGKL
1310 1320 1330 1340 1350
QQFMENKSRM LASGNQPDQD ITHFFQQIQE LNLEMEDQQE NLDTLEHLVT
1360 1370 1380 1390 1400
ELSSCGFALD LCQHQDRVQN LRKDFTELQK TVKEREKDAS SCQEQLDEFR
1410 1420 1430 1440 1450
KLVRTFQKWL KETEGSIPPT ETSMSAKELE KQIEHLKSLL DDWASKGTLV
1460 1470 1480 1490 1500
EEINCKGTSL ENLIMEITAP DSQGKTDLTE IQCDMSDVNL KYEKLGGVLH
1510 1520 1530 1540 1550
ERQESLQAIL NRMEEVHKEA NSVLQWLESK EEVLKSMDAM SSPTKTETVK
1560 1570 1580 1590 1600
AQAESNKAFL AELEQNSPKI QKVKEALAGL LVTYPNSQEA ENWKKIQEEL
1610 1620 1630 1640 1650
NSRWERATEV TVARQRQLEE SASHLACFQA AESQLRPWLM EKELMMGVLG
1660 1670 1680 1690 1700
PLSIDPNMLN AQKQQVQFML KEFEARRQQH EQLNEAAQGI LTGPGDVSLS
1710 1720 1730 1740 1750
TSQVQKELQS INQKWVELTD KLNSRSSQID QAIVKSTQYQ ELLQDLSEKV
1760 1770 1780 1790 1800
RAVGQRLSVQ SAISTQPEAV KQQLEETSEI RSDLEQLDHE VKEAQTLCDE
1810 1820 1830 1840 1850
LSVLIGEQYL KDELKKRLET VALPLQGLED LAADRINRLQ AALASTQQFQ
1860 1870 1880 1890 1900
QMFDELRTWL DDKQSQQAKN CPISAKLERL QSQLQENEEF QKSLNQHSGS
1910 1920 1930 1940 1950
YEVIVAEGES LLLSVPPGEE KRTLQNQLVE LKNHWEELSK KTADRQSRLK
1960 1970 1980 1990 2000
DCMQKAQKYQ WHVEDLVPWI EDCKAKMSEL RVTLDPVQLE SSLLRSKAML
2010 2020 2030 2040 2050
NEVEKRRSLL EILNSAADIL INSSEADEDG IRDEKAGINQ NMDAVTEELQ
2060 2070 2080 2090 2100
AKTGSLEEMT QRLREFQESF KNIEKKVEGA KHQLEIFDAL GSQACSNKNL
2110 2120 2130 2140 2150
EKLRAQQEVL QALEPQVDYL RNFTQGLVED APDGSDASQL LHQAEVAQQE
2160 2170 2180 2190 2200
FLEVKQRVNS GCVMMENKLE GIGQFHCRVR EMFSQLADLD DELDGMGAIG
2210 2220 2230 2240 2250
RDTDSLQSQI EDVRLFLNKI HVLKLDIEAS EAECRHMLEE EGTLDLLGLK
2260 2270 2280 2290 2300
RELEALNKQC GKLTERGKAR QEQLELTLGR VEDFYRKLKG LNDATTAAEE
2310 2320 2330 2340 2350
AEALQWVVGT EVEIINQQLA DFKMFQKEQV DPLQMKLQQV NGLGQGLIQS
2360 2370 2380 2390 2400
AGKDCDVQGL EHDMEEINAR WNTLNKKVAQ RIAQLQEALL HCGKFQDALE
2410 2420 2430 2440 2450
PLLSWLADTE ELIANQKPPS AEYKVVKAQI QEQKLLQRLL DDRKATVDML
2460 2470 2480 2490 2500
QAEGGRIAQS AELADREKIT GQLESLESRW TELLSKAAAR QKQLEDILVL
2510 2520 2530 2540 2550
AKQFHETAEP ISDFLSVTEK KLANSEPVGT QTAKIQQQII RHKALNEEIV
2560 2570 2580 2590 2600
NRKKNVDQAI KNGQALLKQT TGEEVLLIQE KLDGIKTRYA DITVTSSKAL
2610 2620 2630 2640 2650
RTLEQARQLA TKFQSTYEEL TGWLREVEEE LATSGGQSPT GEQIPQFQQR
2660 2670 2680 2690 2700
QKELKKEVME HRLVLDTVNE VSRALLELVP WRAREGLDKL VSDANEQYKL
2710 2720 2730 2740 2750
VSDTIGQRVD EIDAAIQRSQ QYEQAADAEL AWVAETKRKL MALGPIRLEQ
2760 2770 2780 2790 2800
DQTTAQLQVQ KAFSIDIIRH KDSMDELFSH RSEIFGTCGE EQKTVLQEKT
2810 2820 2830 2840 2850
ESLIQQYEAI SLLNSERYAR LERAQVLVNQ FWETYEELSP WIEETRALIA
2860 2870 2880 2890 2900
QLPSPAIDHE QLRQQQEEMR QLRESIAEHK PHIDKLLKIG PQLKELNPEE
2910 2920 2930 2940 2950
GEMVEEKYQK AENMYAQIKE EVRQRALALD EAVSQSTQIT EFHDKIEPML
2960 2970 2980 2990 3000
ETLENLSSRL RMPPLIPAEV DKIRECISDN KSATVELEKL QPSFEALKRR
3010 3020 3030 3040 3050
GEELIGRSQG ADKDLAAKEI QDKLDQMVFF WEDIKARAEE REIKFLDVLE
3060 3070 3080 3090 3100
LAEKFWYDMA ALLTTIKDTQ DIVHDLESPG IDPSIIKQQV EAAETIKEET
3110 3120 3130 3140 3150
DGLHEELEFI RILGADLIFA CGETEKPEVR KSIDEMNNAW ENLNKTWKER
3160 3170 3180 3190 3200
LEKLEDAMQA AVQYQDTLQA MFDWLDNTVI KLCTMPPVGT DLNTVKDQLN
3210 3220 3230 3240 3250
EMKEFKVEVY QQQIEMEKLN HQGELMLKKA TDETDRDIIR EPLTELKHLW
3260 3270 3280 3290 3300
ENLGEKIAHR QHKLEGALLA LGQFQHALEE LMSWLTHTEE LLDAQRPISG
3310 3320 3330 3340 3350
DPKVIEVELA KHHVLKNDVL AHQATVETVN KAGNELLESS AGDDASSLRS
3360 3370 3380 3390 3400
RLEAMNQCWE SVLQKTEERE QQLQSTLQQA QGFHSEIEDF LLELTRMESQ
3410 3420 3430 3440 3450
LSASKPTGGL PETAREQLDT HMELYSQLKA KEETYNQLLD KGRLMLLSRD
3460 3470 3480 3490 3500
DSGSGSKTEQ SVALLEQKWH VVSSKMEERK SKLEEALNLA TEFQNSLQEF
3510 3520 3530 3540 3550
INWLTLAEQS LNIASPPSLI LNTVLSQIEE HKVFANEVNA HRDQIIELDQ
3560 3570 3580 3590 3600
TGNQLKFLSQ KQDVVLIKNL LVSVQSRWEK VVQRSIERGR SLDDARKRAK
3610 3620 3630 3640 3650
QFHEAWKKLI DWLEDAESHL DSELEISNDP DKIKLQLSKH KEFQKTLGGK
3660 3670 3680 3690 3700
QPVYDTTIRT GRALKEKTLL PEDSQKLDNF LGEVRDKWDT VCGKSVERQH
3710 3720 3730 3740 3750
KLEEALLFSG QFMDALQALV DWLYKVEPQL AEDQPVHGDL DLVMNLMDAH
3760 3770 3780 3790 3800
KVFQKELGKR TGTVQVLKRS GRELIENSRD DTTWVKGQLQ ELSTRWDTVC
3810 3820 3830 3840 3850
KLSVSKQSRL EQALKQAEVF RDTVHMLLEW LSEAEQTLRF RGALPDDTEA
3860 3870 3880 3890 3900
LQSLIDTHKE FMKKVEEKRV DVNSAVAMGE VILAVCHPDC ITTIKHWITI
3910 3920 3930 3940 3950
IRARFEEVLT WAKQHQQRLE TALSELVANA ELLEELLAWI QWAETTLIQR
3960 3970 3980 3990 4000
DQEPIPQNID RVKALIAEHQ TFMEEMTRKQ PDVDRVTKTY KRKNIEPTHA
4010 4020 4030 4040 4050
PFIEKSRSGG RKSLSQPTPP PMPILSQSEA KNPRINQLSA RWQQVWLLAL
4060 4070 4080 4090 4100
ERQRKLNDAL DRLEELKEFA NFDFDVWRKK YMRWMNHKKS RVMDFFRRID
4110 4120 4130 4140 4150
KDQDGKITRQ EFIDGILASK FPTTKLEMTA VADIFDRDGD GYIDYYEFVA
4160 4170 4180 4190 4200
ALHPNKDAYR PTTDADKIED EVTRQVAQCK CAKRFQVEQI GENKYRFGDS
4210 4220 4230 4240 4250
QQLRLVRILR STVMVRVGGG WMALDEFLVK NDPCRARGRT NIELREKFIL
4260 4270 4280 4290 4300
PEGASQGMTP FRSRGRRSKP SSRAASPTRS SSSASQSNHS CTSMPSSPAT
4310 4320 4330 4340 4350
PASGTKVIPS SGSKLKRPTP TFHSSRTSLA GDTSNSSSPA STGAKTNRAD
4360 4370 4380 4390 4400
PKKSASRPGS RAGSRAGSRA SSRRGSDASD FDLLETQSAC SDTSESSAAG
4410 4420 4430
GQGNSRRGLN KPSKIPTMSK KTTTASPRTP GPKR
Length:4,434
Mass (Da):505,755
Last modified:February 22, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i50B6DB4F88EFF473
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 21 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9UPN3MACF1_HUMAN
Microtubule-actin cross-linking fac...
MACF1 ABP620, ACF7, KIAA0465, KIAA1251
7,388Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPE1H3BPE1_HUMAN
Microtubule-actin cross-linking fac...
MACF1
7,555Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQK9H3BQK9_HUMAN
Microtubule-actin cross-linking fac...
MACF1
7,592Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UJG2A0A590UJG2_HUMAN
Microtubule-actin cross-linking fac...
MACF1
5,379Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0MQR8A0A7P0MQR8_HUMAN
Microtubule-actin cross-linking fac...
MACF1
7,385Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YYJ5A0A0A6YYJ5_HUMAN
Microtubule-actin cross-linking fac...
MACF1
1,668Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y314H0Y314_HUMAN
Microtubule-actin cross-linking fac...
MACF1
543Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZGX0A0A5F9ZGX0_HUMAN
Microtubule-actin cross-linking fac...
MACF1
2,146Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y4F5H0Y4F5_HUMAN
Microtubule-actin cross-linking fac...
MACF1
455Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y6T5H0Y6T5_HUMAN
Microtubule-actin cross-linking fac...
MACF1
368Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL137853 Genomic DNA No translation available.
AL355477 Genomic DNA No translation available.
AL356055 Genomic DNA No translation available.
AL365277 Genomic DNA No translation available.
AL442071 Genomic DNA No translation available.
KF495921 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000372925; ENSP00000362016; ENSG00000127603

UCSC genome browser

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UCSCi
uc057fam.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137853 Genomic DNA No translation available.
AL355477 Genomic DNA No translation available.
AL356055 Genomic DNA No translation available.
AL365277 Genomic DNA No translation available.
AL442071 Genomic DNA No translation available.
KF495921 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Proteomic databases

EPDiH0Y390
MaxQBiH0Y390
PeptideAtlasiH0Y390
PRIDEiH0Y390
ProteomicsDBi34461

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
31853, 66 antibodies from 18 providers

Genome annotation databases

EnsembliENST00000372925; ENSP00000362016; ENSG00000127603
UCSCiuc057fam.1, human

Organism-specific databases

HGNCiHGNC:13664, MACF1
OpenTargetsiENSG00000127603
VEuPathDBiHostDB:ENSG00000127603

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000155824

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MACF1, human

Gene expression databases

BgeeiENSG00000127603, Expressed in corpus callosum and 250 other tissues
ExpressionAtlasiH0Y390, baseline and differential

Family and domain databases

CDDicd00051, EFh, 1 hit
Gene3Di3.30.920.20, 1 hit
InterProiView protein in InterPro
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR003108, GAR_dom
IPR036534, GAR_dom_sf
IPR043197, Plakin
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
PANTHERiPTHR23169, PTHR23169, 6 hits
PfamiView protein in Pfam
PF13499, EF-hand_7, 1 hit
PF02187, GAS2, 1 hit
PF17902, SH3_10, 1 hit
PF00435, Spectrin, 18 hits
PF18373, Spectrin_like, 1 hit
SMARTiView protein in SMART
SM00054, EFh, 2 hits
SM00243, GAS2, 1 hit
SM00150, SPEC, 30 hits
SUPFAMiSSF143575, SSF143575, 1 hit
SSF47473, SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS51460, GAR, 1 hit
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH0Y390_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H0Y390
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: January 19, 2022
This is version 72 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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