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Protein
Submitted name:

Calcium-activated potassium channel subunit alpha-1

Gene

KCNMA1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channelSAAS annotation, Voltage-gated channelSAAS annotation
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Names & Taxonomyi

Protein namesi
Submitted name:
Calcium-activated potassium channel subunit alpha-1Imported
Gene namesi
Name:KCNMA1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000156113.20
HGNCiHGNC:6284 KCNMA1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000156113

PTM / Processingi

Proteomic databases

PeptideAtlasiH0Y382
PRIDEiH0Y382

Expressioni

Gene expression databases

BgeeiENSG00000156113 Expressed in 215 organ(s), highest expression level in parotid gland
ExpressionAtlasiH0Y382 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH0Y382
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the potassium channel family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1420 Eukaryota
ENOG410YUX1 LUCA
GeneTreeiENSGT00530000063026

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR024939 Ca-act_K_channel_Slo-1
IPR005821 Ion_trans_dom
IPR003929 K_chnl_BK_asu
IPR036291 NAD(P)-bd_dom_sf
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10027:SF28 PTHR10027:SF28, 1 hit
PfamiView protein in Pfam
PF03493 BK_channel_a, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR00169 KCHANNEL
SUPFAMiSSF51735 SSF51735, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 69 potential isoforms that are computationally mapped.Show allAlign All

H0Y382-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XNIHANHLSL DASSSSSSSS SSSSSSSSSS SSSSVHEPKM DALIIPVTME
60 70 80 90 100
VPCDSRGQRM WWAFLASSMV TFFGGLFIIL LWRTLKYLWT VCCHCGGKTK
110 120 130 140 150
EAQKINNGSS QADGTLKPVD EKEEAVAAEV GWMTSVKDWA GVMISAQTLT
160 170 180 190 200
GRVLVVLVFA LSIGALVIYF IDSSNPIESC QNFYKDFTLQ IDMAFNVFFL
210 220 230 240 250
LYFGLRFIAA NDKLWFWLEV NSVVDFFTVP PVFVSVYLNR SWLGLRFLRA
260 270 280 290 300
LRLIQFSEIL QFLNILKTSN SIKLVNLLSI FISTWLTAAG FIHLVENSGD
310 320 330 340 350
PWENFQNNQA LTYWECVYLL MVTMSTVGYG DVYAKTTLGR LFMVFFILGG
360 370 380 390 400
LAMFASYVPE IIELIGNRKK YGGSYSAVSG RKHIVVCGHI TLESVSNFLK
410 420 430 440 450
DFLHKDRDDV NVEIVFLHNI SPNLELEALF KRHFTQVEFY QGSVLNPHDL
460 470 480 490 500
ARVKIESADA CLILANKYCA DPDAEDASNI MRVISIKNYH PKIRIITQML
510 520 530 540 550
QYHNKAHLLN IPSWNWKEGD DAICLAELKL GFIAQSCLAQ GLSTMLANLF
560 570 580 590 600
SMRSFIKIEE DTWQKYYLEG VSNEMYTEYL SSAFVGLSFP TVCELCFVKL
610 620 630 640 650
KLLMIAIEYK SANRESRSRK RILINPGNHL KIQEGTLGFF IASDAKEVKR
660 670 680 690 700
AFFYCKACHD DITDPKRIKK CGCKRLEDEQ PSTLSPKKKQ RNGGMRNSPN
710 720 730 740 750
TSPKLMRHDP LLIPGNDQID NMDSNVKKYD STGMFHWCAP KEIEKVILTR
760 770 780 790 800
SEAAMTVLSG HVVVCIFGDV SSALIGLRNL VMPLRASNFH YHELKHIVFV
810 820 830 840 850
GSIEYLKREW ETLHNFPKVS ILPGTPLSRA DLRAVNINLC DMCVILSANQ
860 870 880 890 900
NNIDDTSLQD KECILASLNI KSMQFDDSIG VLQANSQGFT PPGMDRSSPD
910 920 930 940 950
NSPVHGMLRQ PSITTGVNIP IITELAKPGK LPLVSVNQEK NSGTHILMIT
960 970 980 990 1000
ELVNDTNVQF LDQDDDDDPD TELYLTQPFA CGTAFAVSVL DSLMSATYFN
1010 1020 1030 1040 1050
DNILTLIRTL VTGGATPELE ALIAEENALR GGYSTPQTLA NRDRCRVAQL
1060 1070 1080 1090 1100
ALLDGPFADL GDGGCYGDLF CKALKTYNML CFGIYRLRDA HLSTPSQCTK
1110 1120 1130 1140 1150
RYVITNPPYE FELVPTDLIF CLMQFDHNAG QSRASLSHSS HSSQSSSKKS
1160 1170 1180
SSVHSIPSTA NRQNRPKSRE SRDKQKKEMV YR
Length:1,182
Mass (Da):132,332
Last modified:June 7, 2017 - v3
Checksum:iCACA9CD07315CDED
GO

Computationally mapped potential isoform sequencesi

There are 69 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q12791KCMA1_HUMAN
Calcium-activated potassium channel...
KCNMA1 KCNMA, SLO
1,236Annotation score:
A0A1W2PRT6A0A1W2PRT6_HUMAN
Calcium-activated potassium channel...
KCNMA1
383Annotation score:
Q5SVJ8Q5SVJ8_HUMAN
Calcium-activated potassium channel...
KCNMA1
1,288Annotation score:
D5MRH1D5MRH1_HUMAN
Calcium-activated potassium channel...
KCNMA1
1,128Annotation score:
Q5SVK0Q5SVK0_HUMAN
Calcium-activated potassium channel...
KCNMA1
1,195Annotation score:
Q5SVK5Q5SVK5_HUMAN
Calcium-activated potassium channel...
KCNMA1
1,232Annotation score:
H0Y379H0Y379_HUMAN
Calcium-activated potassium channel...
KCNMA1
1,192Annotation score:
Q5SVJ9Q5SVJ9_HUMAN
Calcium-activated potassium channel...
KCNMA1
1,235Annotation score:
B7ZMF5B7ZMF5_HUMAN
Calcium-activated potassium channel...
KCNMA1
1,208Annotation score:
J3KQ16J3KQ16_HUMAN
Calcium-activated potassium channel...
KCNMA1
1,040Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011439 Genomic DNA No translation available.
AC021032 Genomic DNA No translation available.
AC067745 Genomic DNA No translation available.
AL157833 Genomic DNA No translation available.
AL607069 Genomic DNA No translation available.
AL627447 Genomic DNA No translation available.
AL731556 Genomic DNA No translation available.
AL731560 Genomic DNA No translation available.
AL731575 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000372421; ENSP00000361498; ENSG00000156113
UCSCiuc057uie.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011439 Genomic DNA No translation available.
AC021032 Genomic DNA No translation available.
AC067745 Genomic DNA No translation available.
AL157833 Genomic DNA No translation available.
AL607069 Genomic DNA No translation available.
AL627447 Genomic DNA No translation available.
AL731556 Genomic DNA No translation available.
AL731560 Genomic DNA No translation available.
AL731575 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH0Y382
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiH0Y382
PRIDEiH0Y382

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372421; ENSP00000361498; ENSG00000156113
UCSCiuc057uie.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000156113.20
HGNCiHGNC:6284 KCNMA1
OpenTargetsiENSG00000156113
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1420 Eukaryota
ENOG410YUX1 LUCA
GeneTreeiENSGT00530000063026

Miscellaneous databases

ChiTaRSiKCNMA1 human

Gene expression databases

BgeeiENSG00000156113 Expressed in 215 organ(s), highest expression level in parotid gland
ExpressionAtlasiH0Y382 baseline and differential

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR024939 Ca-act_K_channel_Slo-1
IPR005821 Ion_trans_dom
IPR003929 K_chnl_BK_asu
IPR036291 NAD(P)-bd_dom_sf
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10027:SF28 PTHR10027:SF28, 1 hit
PfamiView protein in Pfam
PF03493 BK_channel_a, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR00169 KCHANNEL
SUPFAMiSSF51735 SSF51735, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH0Y382_HUMAN
AccessioniPrimary (citable) accession number: H0Y382
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: June 7, 2017
Last modified: September 12, 2018
This is version 53 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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