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Protein
Submitted name:

Zyxin

Gene

ZYX

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
ZyxinImported
Gene namesi
Name:ZYXImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000159840.15
HGNCiHGNC:13200 ZYX

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000159840

PTM / Processingi

Proteomic databases

MaxQBiH0Y2Y8
PeptideAtlasiH0Y2Y8
PRIDEiH0Y2Y8

Expressioni

Gene expression databases

BgeeiENSG00000159840 Expressed in 229 organ(s), highest expression level in blood
ExpressionAtlasiH0Y2Y8 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH0Y2Y8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini350 – 409LIM zinc-bindingInterPro annotationAdd BLAST60
Domaini410 – 470LIM zinc-bindingInterPro annotationAdd BLAST61
Domaini471 – 540LIM zinc-bindingInterPro annotationAdd BLAST70

Keywords - Domaini

LIM domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1701 Eukaryota
ENOG410Y3GP LUCA
GeneTreeiENSGT00760000119039

Family and domain databases

InterProiView protein in InterPro
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 3 hits
SMARTiView protein in SMART
SM00132 LIM, 3 hits
PROSITEiView protein in PROSITE
PS50023 LIM_DOMAIN_2, 3 hits

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

H0Y2Y8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
AAPRPSPAIS VSVSAPAFYA PQKKFGPVVA PKPKVNPFRP GDSEPPPAPG
60 70 80 90 100
AQRAQMGRVG EIPPPPPEDF PLPPPPLAGD GDDAEGALGG AFPPPPPPIE
110 120 130 140 150
ESFPPAPLEE EIFPSPPPPP EEEGGPEAPI PPPPQVSSGY VPPPVATPFS
160 170 180 190 200
SKSSTKPAAG GTAPLPPWKS PSSSQPLPQV PAPAQSQTQF HVQPQPQPKP
210 220 230 240 250
QVQLHVQSQT QPVSLANTQP RGPPASSPAP APKFSPVTPK FTPVASKFSP
260 270 280 290 300
GAPGGSGSQP NQKLGHPEAL SAGTGSPQPP SFTYAQQREK PRVQEKQHPV
310 320 330 340 350
PPPAQNQNQV RSPGAPGPLT LKEVEELEQL TQQLMQDMEH PQRQNVAVNE
360 370 380 390 400
LCGRCHQPLA RAQPAVRALG QLFHIACFTC HQCAQQLQGQ QFYSLEGAPY
410 420 430 440 450
CEGCYTDTLE KCNTCGEPIT DRMLRATGKA YHPHCFTCVV CARPLEGTSF
460 470 480 490 500
IVDQANRPHC VPDYHKQYAP RCSVCSEPIM PEPGRDETVR VVALDKNFHM
510 520 530 540
KCYKCEDCGK PLSIEADDNG CFPLDGHVLC RKCHTARAQT
Length:540
Mass (Da):57,643
Last modified:February 22, 2012 - v1
Checksum:i48FFB79A37B5FE7B
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q15942ZYX_HUMAN
Zyxin
ZYX
572Annotation score:
C9JJK5C9JJK5_HUMAN
Zyxin
ZYX
171Annotation score:
H7C3D3H7C3D3_HUMAN
Zyxin
ZYX
176Annotation score:
C9IZ41C9IZ41_HUMAN
Zyxin
ZYX
164Annotation score:
H7C3R3H7C3R3_HUMAN
Zyxin
ZYX
177Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092214 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000354434; ENSP00000346417; ENSG00000159840
UCSCiuc064ivy.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092214 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH0Y2Y8
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiH0Y2Y8
PeptideAtlasiH0Y2Y8
PRIDEiH0Y2Y8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354434; ENSP00000346417; ENSG00000159840
UCSCiuc064ivy.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000159840.15
HGNCiHGNC:13200 ZYX
OpenTargetsiENSG00000159840
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1701 Eukaryota
ENOG410Y3GP LUCA
GeneTreeiENSGT00760000119039

Miscellaneous databases

ChiTaRSiZYX human

Gene expression databases

BgeeiENSG00000159840 Expressed in 229 organ(s), highest expression level in blood
ExpressionAtlasiH0Y2Y8 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 3 hits
SMARTiView protein in SMART
SM00132 LIM, 3 hits
PROSITEiView protein in PROSITE
PS50023 LIM_DOMAIN_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiH0Y2Y8_HUMAN
AccessioniPrimary (citable) accession number: H0Y2Y8
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: September 12, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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